| 1 | Mon Nov 6 | vs Towson | W75-57 | 1-0 | 1.000 | - | PACN | CU Events Center · Boulder, CO |
| 2 | Fri Nov 10 | vs Grambling | W95-63 | 2-0 | 1.000 | - | | CU Events Center · Boulder, CO |
| 3 | Tue Nov 14 | vs Milwaukee | W106-79 | 3-0 | 1.000 | #25 | PACN | CU Events Center · Boulder, CO |
| 4 | Mon Nov 20 | at Richmond | W64-59 | 4-0 | 1.000 | #18 | CBS | Robins Center · Richmond, VA |
| 5 | Tue Nov 21 | vs Florida St | L71-77 (OT) | 4-1 | .800 | #18 | CBS | CU Events Center · Boulder, CO |
| 6 | Sun Nov 26 | vs Iona | W85-68 | 5-1 | .833 | #18 | PACN | CU Events Center · Boulder, CO |
| 7 | Wed Nov 29 | at #20Colorado St | L83-88 | 5-2 | .714 | - | CBS | Moby Arena · Fort Collins, CO |
| 8 | Sun Dec 3 | vs Pepperdine | W91-66 | 6-2 | .750 | - | PACN | CU Events Center · Boulder, CO |
| 9 | Sun Dec 10 | at #15Miami | W90-63 | 7-2 | .778 | - | ESPN2 | Watsco Center · Coral Gables, FL |
| 10 | Fri Dec 15 | vs N Colorado | W90-68 | 8-2 | .800 | - | PACN | CU Events Center · Boulder, CO |
| 11 | Thu Dec 21 | vs Utah Tech | W98-71 | 9-2 | .818 | - | PACN | CU Events Center · Boulder, CO |
| 12 | Fri Dec 29 | vs Washington | W73-69 | 10-2 | .833 | - | ESPNU | CU Events Center · Boulder, CO |
| 13 | Sun Dec 31 | vs Washington St | W74-67 | 11-2 | .846 | - | PACN | CU Events Center · Boulder, CO |
| 14 | Thu Jan 4 | at #10Arizona | L50-97 | 11-3 | .786 | - | ESPN | McKale Center · Tucson, AZ |
| 15 | Sat Jan 6 | at Arizona St | L73-76 | 11-4 | .733 | - | ESPNU | Desert Financial Arena · Tempe, AZ |
| 16 | Wed Jan 10 | at California | L78-82 | 11-5 | .688 | - | ESPNU | Haas Pavilion · Berkeley, CA |
| 17 | Sat Jan 13 | vs USC | W68-58 | 12-5 | .706 | - | ESPN2 | CU Events Center · Boulder, CO |
| 18 | Thu Jan 18 | vs Oregon | W86-70 | 13-5 | .722 | - | FS1 | CU Events Center · Boulder, CO |
| 19 | Sat Jan 20 | vs Oregon St | W90-57 | 14-5 | .737 | - | PACN | CU Events Center · Boulder, CO |
| 20 | Wed Jan 24 | atWashington | W98-81 | 15-5 | .750 | - | ESPNU | Alaska Airlines Arena · Seattle, WA |
| 21 | Sat Jan 27 | atWashington St | L69-78 | 15-6 | .714 | - | PACN | Friel Court at Beasley Coliseum · Pullman, WA |
| 22 | Sat Feb 3 | at Utah | L68-73 | 15-7 | .682 | - | PACN | Jon M. Huntsman Center · Salt Lake City, UT |
| 23 | Thu Feb 8 | vsArizona St | W82-70 | 16-7 | .696 | - | FS1 | CU Events Center · Boulder, CO |
| 24 | Sat Feb 10 | vs#8Arizona | L79-99 | 16-8 | .667 | - | ESPN | CU Events Center · Boulder, CO |
| 25 | Thu Feb 15 | at UCLA | L60-64 | 16-9 | .640 | - | ESPN | Pauley Pavilion · Los Angeles, CA |
| 26 | Sat Feb 17 | atUSC | W92-89 (2OT) | 17-9 | .654 | - | ESPN | Galen Center · Los Angeles, CA |
| 27 | Sat Feb 24 | vsUtah | W89-65 | 18-9 | .667 | - | PACN | CU Events Center · Boulder, CO |
| 28 | Wed Feb 28 | vsCalifornia | W88-78 | 19-9 | .679 | - | PACN | CU Events Center · Boulder, CO |
| 29 | Sun Mar 3 | vs Stanford | W81-71 | 20-9 | .690 | - | FS1 | CU Events Center · Boulder, CO |
| 30 | Thu Mar 7 | atOregon | W79-75 | 21-9 | .700 | - | ESPN2 | Matthew Knight Arena · Eugene, OR |
| 31 | Sat Mar 9 | atOregon St | W73-57 | 22-9 | .710 | - | PACN | Gill Coliseum · Corvallis, OR |
| 32 | Thu Mar 14 | vsUtah | W72-58 | 23-9 | .719 | - | FS1 | CU Events Center · Boulder, CO |
| 33 | Fri Mar 15 | at#22Washington St | W58-52 | 24-9 | .727 | - | FS1 | Friel Court at Beasley Coliseum · Pullman, WA |
| 34 | Sat Mar 16 | vsOregon | L68-75 | 24-10 | .706 | - | FOX | CU Events Center · Boulder, CO |
| 35 | Wed Mar 20 | at #10Boise St | W60-53 | 25-10 | .714 | #10 | truTV | ExtraMile Arena · Boise, ID |
| 36 | Fri Mar 22 | at #7Florida | W102-100 | 26-10 | .722 | #10 | TBS | Exactech Arena at Stephen C. O'Connell Center · Gainesville, FL |
| 37 | Sun Mar 24 | at #2Marquette | L77-81 | 26-11 | .703 | #10 | CBS | Fiserv Forum · Milwaukee, WI |
