| 1 | Mon Nov 4 | vs North Dakota | W82-56 | 1-0 | 1.000 | - | | Moby Arena · Fort Collins, CO |
| 2 | Fri Nov 8 | vs Tennessee St | W87-79 (OT) | 2-0 | 1.000 | - | | Moby Arena · Fort Collins, CO |
| 3 | Tue Nov 12 | vs Denver | W74-65 | 3-0 | 1.000 | - | | Moby Arena · Fort Collins, CO |
| 4 | Sat Nov 16 | at #25Ole Miss | L69-84 | 3-1 | .750 | - | ESPN+ | SJB Pavilion · Oxford, MS |
| 5 | Fri Nov 22 | vs UC Riverside | L75-77 (OT) | 3-2 | .600 | - | | Moby Arena · Fort Collins, CO |
| 6 | Thu Nov 28 | vs Washington | L67-73 | 3-3 | .500 | - | truTV | Moby Arena · Fort Collins, CO |
| 7 | Fri Nov 29 | vs TCU | W76-72 (OT) | 4-3 | .571 | - | | Moby Arena · Fort Collins, CO |
| 8 | Wed Dec 4 | vs LMU | W83-54 | 5-3 | .625 | - | | Moby Arena · Fort Collins, CO |
| 9 | Sat Dec 7 | at Colorado | L55-72 | 5-4 | .556 | - | ESPN+ | CU Events Center · Boulder, CO |
| 10 | Sat Dec 14 | vs VCU | L68-76 | 5-5 | .500 | - | | Moby Arena · Fort Collins, CO |
| 11 | Tue Dec 17 | vs Radford | W78-68 | 6-5 | .545 | - | | Moby Arena · Fort Collins, CO |
| 12 | Sat Dec 21 | at Nevada | W66-64 | 7-5 | .583 | - | | Lawlor Events Center · Reno, NV |
| 13 | Sat Dec 28 | vs New Mexico | L68-76 | 7-6 | .538 | - | | Moby Arena · Fort Collins, CO |
| 14 | Tue Dec 31 | at San Jose St | W72-50 | 8-6 | .571 | - | | Provident Credit Union Event Center · San Jose, CA |
| 15 | Tue Jan 7 | vs Fresno St | W91-64 | 9-6 | .600 | - | | Moby Arena · Fort Collins, CO |
| 16 | Sat Jan 11 | vs UNLV | W84-62 | 10-6 | .625 | - | | Moby Arena · Fort Collins, CO |
| 17 | Tue Jan 14 | at SDSU | L60-75 | 10-7 | .588 | - | CBS | Viejas Arena · San Diego, CA |
| 18 | Sat Jan 18 | at Wyoming | W79-63 | 11-7 | .611 | - | | Arena Auditorium · Laramie, WY |
| 19 | Wed Jan 22 | vs Boise St | W75-72 | 12-7 | .632 | - | CBS | Moby Arena · Fort Collins, CO |
| 20 | Sat Jan 25 | atFresno St | W69-64 | 13-7 | .650 | - | | Save Mart Center · Fresno, CA |
| 21 | Tue Jan 28 | vs Air Force | W79-58 | 14-7 | .667 | - | | Moby Arena · Fort Collins, CO |
| 22 | Wed Feb 5 | atNew Mexico | L65-87 | 14-8 | .636 | - | FS1 | The Pit · Albuquerque, NM |
| 23 | Sat Feb 8 | vsSDSU | W68-63 | 15-8 | .652 | - | CBS | Moby Arena · Fort Collins, CO |
| 24 | Tue Feb 11 | at Utah State | L85-93 | 15-9 | .625 | - | FS1 | Dee Glen Smith Spectrum · Logan, UT |
| 25 | Sat Feb 15 | vsWyoming | W88-53 | 16-9 | .640 | - | | Moby Arena · Fort Collins, CO |
| 26 | Tue Feb 18 | vsNevada | W79-71 | 17-9 | .654 | - | | Moby Arena · Fort Collins, CO |
| 27 | Sat Feb 22 | atUNLV | W61-53 | 18-9 | .667 | - | CBS | Thomas & Mack Center · Las Vegas, NV |
| 28 | Tue Feb 25 | atAir Force | W77-55 | 19-9 | .679 | - | | Clune Arena · Colorado Springs, CO |
| 29 | Sat Mar 1 | vsUtah State | W93-66 | 20-9 | .690 | - | FS1 | Moby Arena · Fort Collins, CO |
| 30 | Tue Mar 4 | vsSan Jose St | W83-56 | 21-9 | .700 | - | | Moby Arena · Fort Collins, CO |
| 31 | Fri Mar 7 | atBoise St | W83-73 | 22-9 | .710 | - | FS1 | ExtraMile Arena · Boise, ID |
| 32 | Thu Mar 13 | vsNevada | W67-59 | 23-9 | .719 | - | CBS | Moby Arena · Fort Collins, CO |
| 33 | Fri Mar 14 | vsUtah State | W83-72 | 24-9 | .727 | - | CBS | Moby Arena · Fort Collins, CO |
| 34 | Sat Mar 15 | vsBoise St | W69-56 | 25-9 | .735 | - | CBS | Moby Arena · Fort Collins, CO |
| 35 | Fri Mar 21 | at #5Memphis | W78-70 | 26-9 | .743 | #12 | TBS | FedExForum · Memphis, TN |
| 36 | Sun Mar 23 | at #4Maryland | L71-72 | 26-10 | .722 | #12 | TBS | XFINITY Center · College Park, MD |
