| 1 | Mon Nov 4 | vs Chicago St | W79-72 | 1-0 | 1.000 | - | ESPN+ | Joseph J. Gentile Arena · Chicago, IL |
| 2 | Thu Nov 7 | vs Detroit Mercy | W87-65 | 2-0 | 1.000 | - | ESPN+ | Joseph J. Gentile Arena · Chicago, IL |
| 3 | Sun Nov 10 | vs TBD | W105-53 | 3-0 | 1.000 | - | ESPN+ | Joseph J. Gentile Arena · Chicago, IL |
| 4 | Fri Nov 15 | at Princeton | W73-68 | 4-0 | 1.000 | - | ESPN+ | Jadwin Gymnasium · Princeton, NJ |
| 5 | Tue Nov 19 | vs Southern Utah | W76-72 | 5-0 | 1.000 | - | ESPN+ | Joseph J. Gentile Arena · Chicago, IL |
| 6 | Sat Nov 23 | vs Tulsa | W89-53 | 6-0 | 1.000 | - | ESPN+ | Joseph J. Gentile Arena · Chicago, IL |
| 7 | Tue Dec 3 | vs E Michigan | W76-54 | 7-0 | 1.000 | - | ESPN+ | Joseph J. Gentile Arena · Chicago, IL |
| 8 | Sat Dec 7 | vs South Florida | W74-72 | 8-0 | 1.000 | - | USA Net | Joseph J. Gentile Arena · Chicago, IL |
| 9 | Sun Dec 15 | vs San Francisco | L66-76 | 8-1 | .889 | - | ESPN+ | Joseph J. Gentile Arena · Chicago, IL |
| 10 | Wed Dec 18 | vs Canisius | W72-60 | 9-1 | .900 | - | ESPN+ | Joseph J. Gentile Arena · Chicago, IL |
| 11 | Sun Dec 22 | at Oakland | L71-72 | 9-2 | .818 | - | ESPN2 | Athletics Center O'rena · Rochester, MI |
| 12 | Mon Dec 23 | vs Charleston | L68-77 | 9-3 | .750 | - | ESPNU | Joseph J. Gentile Arena · Chicago, IL |
| 13 | Wed Dec 25 | at Murray St | L68-71 | 9-4 | .692 | - | ESPNU | CFSB Center · Murray, KY |
| 14 | Sat Jan 4 | vs VCU | L65-84 | 9-5 | .643 | - | CBS | Joseph J. Gentile Arena · Chicago, IL |
| 15 | Wed Jan 8 | at La Salle | W79-68 | 10-5 | .667 | - | ESPN+ | Tom Gola Arena · Philadelphia, PA |
| 16 | Sat Jan 11 | at Saint Joseph's | L57-93 | 10-6 | .625 | - | CBS | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 17 | Wed Jan 15 | vs Rhode Island | W81-77 | 11-6 | .647 | - | CBS | Joseph J. Gentile Arena · Chicago, IL |
| 18 | Sat Jan 18 | at Dayton | L81-83 (OT) | 11-7 | .611 | - | CBS | UD Arena · Dayton, OH |
| 19 | Wed Jan 22 | vs Fordham | W70-66 | 12-7 | .632 | - | ESPN+ | Joseph J. Gentile Arena · Chicago, IL |
| 20 | Wed Jan 29 | at George Mason | L53-58 (OT) | 12-8 | .600 | - | ESPN+ | EagleBank Arena · Fairfax, VA |
| 21 | Sat Feb 1 | vsSaint Joseph's | W58-55 | 13-8 | .619 | - | CBS | Joseph J. Gentile Arena · Chicago, IL |
| 22 | Tue Feb 4 | vs St Bonaventure | W77-53 | 14-8 | .636 | - | CBS | Joseph J. Gentile Arena · Chicago, IL |
| 23 | Sat Feb 8 | at Duquesne | L56-69 | 14-9 | .609 | - | CBS | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 24 | Tue Feb 11 | at Richmond | W87-80 (OT) | 15-9 | .625 | - | ESPN+ | Robins Center · Richmond, VA |
| 25 | Fri Feb 14 | vs Saint Louis | W78-69 | 16-9 | .640 | - | ESPN2 | Joseph J. Gentile Arena · Chicago, IL |
| 26 | Tue Feb 18 | at Davidson | W77-69 | 17-9 | .654 | - | CBS | John M. Belk Arena · Davidson, NC |
| 27 | Fri Feb 21 | vsDayton | W76-72 | 18-9 | .667 | - | ESPN2 | Joseph J. Gentile Arena · Chicago, IL |
| 28 | Wed Feb 26 | vs G Washington | W77-57 | 19-9 | .679 | - | ESPN+ | Joseph J. Gentile Arena · Chicago, IL |
| 29 | Sat Mar 1 | atSaint Louis | L67-98 | 19-10 | .655 | - | CBS | Chaifetz Arena · St. Louis, MO |
| 30 | Wed Mar 5 | vsDavidson | W82-72 | 20-10 | .667 | - | CBS | Joseph J. Gentile Arena · Chicago, IL |
| 31 | Sat Mar 8 | at UMass | W74-51 | 21-10 | .677 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 32 | Fri Mar 14 | vsSaint Louis | W72-64 | 22-10 | .688 | - | USA Net | Joseph J. Gentile Arena · Chicago, IL |
| 33 | Sat Mar 15 | atVCU | L55-62 | 22-11 | .667 | - | CBS | Stuart C. Siegel Center · Richmond, VA |
| 34 | Wed Mar 19 | at San Jose St | W73-70 | 23-11 | .676 | - | ESPN2 | Provident Credit Union Event Center · San Jose, CA |
| 35 | Sun Mar 23 | atSan Francisco | W77-76 | 24-11 | .686 | - | ESPN2 | War Memorial at the Sobrato Center · San Francisco, CA |
| 36 | Wed Mar 26 | vs Kent State | W72-62 | 25-11 | .694 | - | ESPN2 | Joseph J. Gentile Arena · Chicago, IL |
| 37 | Tue Apr 1 | vs Chattanooga | L73-80 | 25-12 | .676 | - | ESPN2 | Joseph J. Gentile Arena · Chicago, IL |
