| 1 | Mon Nov 7 | vs Fairleigh | W88-82 (OT) | 1-0 | 1.000 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 2 | Fri Nov 11 | atUIC | W70-63 | 2-0 | 1.000 | - | | Credit Union 1 Arena · Chicago, IL |
| 3 | Thu Nov 17 | atTulsa | L66-85 | 2-1 | .667 | - | ESPNU | The HTC Center · Conway, SC |
| 4 | Fri Nov 18 | vsBoise St | L48-70 | 2-2 | .500 | - | | The HTC Center · Conway, SC |
| 5 | Sun Nov 20 | vsTexas A&M | L51-67 | 2-3 | .400 | - | | The HTC Center · Conway, SC |
| 6 | Fri Nov 25 | atHarvard | L55-61 | 2-4 | .333 | - | | Lavietes Pavilion · Cambridge, MA |
| 7 | Wed Nov 30 | vsC Arkansas | W85-70 | 3-4 | .429 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 8 | Sat Dec 3 | vsDePaul | L72-78 (OT) | 3-5 | .375 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 9 | Tue Dec 6 | vsGreen Bay | W70-46 | 4-5 | .444 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 10 | Sat Dec 10 | atClemson | W76-58 | 5-5 | .500 | - | ACC Network | State Farm Arena · Atlanta, GA |
| 11 | Sun Dec 18 | vsAlbany | W68-56 | 6-5 | .545 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 12 | Thu Dec 22 | atStanford | L62-75 | 6-6 | .500 | - | PACN | Maples Pavilion · Stanford, CA |
| 13 | Sat Dec 31 | vsG Washington | L87-97 | 6-7 | .462 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 14 | Wed Jan 4 | atDavidson | L57-80 | 6-8 | .429 | - | CBS | John M. Belk Arena · Davidson, NC |
| 15 | Sat Jan 7 | atGeorge Mason | L75-86 | 6-9 | .400 | - | | EagleBank Arena · Fairfax, VA |
| 16 | Tue Jan 10 | vsVCU | L64-78 | 6-10 | .375 | - | CBS | Joseph J. Gentile Arena · Chicago, IL |
| 17 | Sat Jan 14 | atSaint Joseph's | L55-86 | 6-11 | .353 | - | | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 18 | Wed Jan 18 | vsSaint Louis | L59-76 | 6-12 | .333 | - | CBS | Joseph J. Gentile Arena · Chicago, IL |
| 19 | Sat Jan 21 | vsSt Bonaventure | W67-55 | 7-12 | .368 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 20 | Wed Jan 25 | atDuquesne | L58-72 | 7-13 | .350 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 21 | Tue Jan 31 | atDayton | L81-85 (OT) | 7-14 | .333 | - | CBS | UD Arena · Dayton, OH |
| 22 | Sat Feb 4 | vsGeorge Mason | W69-61 | 8-14 | .364 | - | USA Net | Joseph J. Gentile Arena · Chicago, IL |
| 23 | Wed Feb 8 | vsSaint Joseph's | L71-83 | 8-15 | .348 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 24 | Sat Feb 11 | atRichmond | L71-74 | 8-16 | .333 | - | ESPNU | Robins Center · Richmond, VA |
| 25 | Tue Feb 14 | atUMass | W64-62 | 9-16 | .360 | - | | William D. Mullins Memorial Center · Amherst, MA |
| 26 | Fri Feb 17 | vsDayton | L49-65 | 9-17 | .346 | - | ESPN2 | Joseph J. Gentile Arena · Chicago, IL |
| 27 | Wed Feb 22 | vsFordham | L69-71 | 9-18 | .333 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 28 | Sat Feb 25 | atSaint Louis | L62-81 | 9-19 | .321 | - | CBS | Chaifetz Arena · St. Louis, MO |
| 29 | Wed Mar 1 | vsRhode Island | L77-79 | 9-20 | .310 | - | CBS | Joseph J. Gentile Arena · Chicago, IL |
| 30 | Sat Mar 4 | atLa Salle | W76-73 | 10-20 | .333 | - | | Tom Gola Arena · Philadelphia, PA |
| 31 | Tue Mar 7 | atSaint Joseph's | L67-72 | 10-21 | .323 | - | | Michael J. Hagan '85 Arena · Philadelphia, PA |
