| 1 | Mon Nov 3 | vs Cleveland St | 8:00 PM | 23-13 | .639 | - | ESPN+ | Joseph J. Gentile Arena · Chicago, IL |
| 2 | Thu Nov 6 | vsMercyhurst | TBD | 15-16 | .484 | - | ESPN+ | Joseph J. Gentile Arena · Chicago, IL |
| 3 | Sun Nov 9 | vsNorth Texas | TBD | 27-9 | .750 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 4 | Thu Nov 13 | atWichita St | 7:30 PM | 19-15 | .559 | - | ESPN+ | Charles Koch Arena · Wichita, KS |
| 5 | Sun Nov 16 | vsColorado St | 5:00 PM | 26-10 | .722 | - | ESPN+ | Joseph J. Gentile Arena · Chicago, IL |
| 6 | Fri Nov 21 | vsN Illinois | TBD | 6-25 | .194 | - | ESPN+ | Joseph J. Gentile Arena · Chicago, IL |
| 7 | Tue Nov 25 | vsNorthern Iowa | 4:00 PM | 20-13 | .606 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 8 | Tue Dec 2 | vsC Michigan | TBD | 14-17 | .452 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 9 | Sat Dec 6 | vsPrinceton | TBD | 19-11 | .633 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 10 | Sun Dec 14 | vsChicago St | TBD | 4-28 | .125 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 11 | Wed Dec 17 | atSan Francisco | TBD | 25-10 | .714 | - | | War Memorial at the Sobrato Center · San Francisco, CA |
| 12 | Sat Dec 20 | atSanta Clara | 7:00 PM | 21-13 | .618 | - | | Leavey Center · Santa Clara, CA |
| 13 | Wed Dec 31 | atRhode Island | TBD | 18-13 | .581 | - | | Ryan Center · Kingston, RI |
| 14 | Sat Jan 3 | vsDayton | TBD | 23-11 | .676 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 15 | Wed Jan 7 | vsDavidson | TBD | 17-16 | .515 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 16 | Sat Jan 10 | atG Washington | 3:00 PM | 21-13 | .618 | - | | Charles E. Smith Center · Washington, D.C. |
| 17 | Tue Jan 13 | vsGeorge Mason | 7:00 PM | 27-9 | .750 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 18 | Fri Jan 16 | atDayton | TBD | 23-11 | .676 | - | | UD Arena · Dayton, OH |
| 19 | Tue Jan 20 | atSt Bonaventure | TBD | 22-12 | .647 | - | | Reilly Center · Saint Bonaventure, NY |
| 20 | Sat Jan 24 | vsDuquesne | TBD | 13-19 | .406 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 21 | Tue Jan 27 | vsSaint Joseph's | TBD | 22-13 | .629 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 22 | Fri Jan 30 | atVCU | TBD | 28-7 | .800 | - | | Stuart C. Siegel Center · Richmond, VA |
| 23 | Tue Feb 3 | vsLa Salle | 7:00 PM | 14-19 | .424 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 24 | Fri Feb 6 | atDavidson | TBD | 17-16 | .515 | - | | John M. Belk Arena · Davidson, NC |
| 25 | Fri Feb 13 | vsSaint Louis | TBD | 19-15 | .559 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 26 | Wed Feb 18 | atFordham | 7:00 PM | 12-21 | .364 | - | | Rose Hill Gymnasium · Bronx, NY |
| 27 | Sat Feb 21 | atSaint Joseph's | TBD | 22-13 | .629 | - | | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 28 | Sat Feb 28 | vsRichmond | TBD | 10-22 | .313 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 29 | Wed Mar 4 | atSaint Louis | TBD | 19-15 | .559 | - | | Chaifetz Arena · St. Louis, MO |
| 30 | Sat Mar 7 | vsG Washington | 2:00 PM | 21-13 | .618 | - | | Joseph J. Gentile Arena · Chicago, IL |
