| 10 | Sat Dec 6 | vs Princeton | 2:30 PM | 3-8 | .273 | - | USA Net | Joseph J. Gentile Arena · Chicago, IL |
| 11 | Sun Dec 14 | vsChicago St | 5:00 PM | 1-8 | .111 | - | ESPN+ | Joseph J. Gentile Arena · Chicago, IL |
| 12 | Wed Dec 17 | atSan Francisco | 10:00 PM | 5-4 | .556 | - | ESPN+ | Chase Center · San Francisco, CA |
| 13 | Sat Dec 20 | atSanta Clara | 7:00 PM | 8-1 | .889 | - | | Leavey Center · Santa Clara, CA |
| 14 | Wed Dec 31 | atRhode Island | 12:00 PM | 7-2 | .778 | - | ESPN+ | Ryan Center · Kingston, RI |
| 15 | Sat Jan 3 | vsDayton | 2:00 PM | 7-2 | .778 | - | CBSSN | Joseph J. Gentile Arena · Chicago, IL |
| 16 | Wed Jan 7 | vsDavidson | 9:00 PM | 6-1 | .857 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 17 | Sat Jan 10 | atG Washington | 3:00 PM | 7-2 | .778 | - | | Charles E. Smith Center · Washington, D.C. |
| 18 | Tue Jan 13 | vsGeorge Mason | 7:00 PM | 9-0 | 1.000 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 19 | Fri Jan 16 | atDayton | 8:30 PM | 7-2 | .778 | - | ESPN2 | UD Arena · Dayton, OH |
| 20 | Tue Jan 20 | atSt Bonaventure | 7:00 PM | 8-1 | .889 | - | ESPN+ | Reilly Center · Saint Bonaventure, NY |
| 21 | Sat Jan 24 | vsDuquesne | 2:00 PM | 5-3 | .625 | - | ESPN+ | Joseph J. Gentile Arena · Chicago, IL |
| 22 | Tue Jan 27 | vsSaint Joseph's | 9:00 PM | 4-3 | .571 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 23 | Fri Jan 30 | atVCU | 9:00 PM | 5-3 | .625 | - | ESPN2 | Stuart C. Siegel Center · Richmond, VA |
| 24 | Tue Feb 3 | vsLa Salle | 8:00 PM | 3-6 | .333 | - | ESPN+ | Joseph J. Gentile Arena · Chicago, IL |
| 25 | Fri Feb 6 | atDavidson | 6:00 PM | 6-1 | .857 | - | | John M. Belk Arena · Davidson, NC |
| 26 | Fri Feb 13 | vsSaint Louis | 8:30 PM | 7-1 | .875 | - | ESPN2 | Joseph J. Gentile Arena · Chicago, IL |
| 27 | Wed Feb 18 | atFordham | 7:00 PM | 6-3 | .667 | - | ESPN+ | Rose Hill Gymnasium · Bronx, NY |
| 28 | Sat Feb 21 | atSaint Joseph's | 12:00 PM | 4-3 | .571 | - | | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 29 | Sat Feb 28 | vsRichmond | 4:00 PM | 7-1 | .875 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 30 | Wed Mar 4 | atSaint Louis | 8:00 PM | 7-1 | .875 | - | | Chaifetz Arena · St. Louis, MO |
| 31 | Sat Mar 7 | vsG Washington | 2:00 PM | 7-2 | .778 | - | | Joseph J. Gentile Arena · Chicago, IL |
