| 1 | Mon Nov 3 | vs Cleveland St | W91-88 | 1-0 | 1.000 | - | ESPN+ | Joseph J. Gentile Arena · Chicago, IL |
| 2 | Thu Nov 6 | vsMercyhurst | L65-73 | 1-1 | .500 | - | ESPN+ | Joseph J. Gentile Arena · Chicago, IL |
| 3 | Sun Nov 9 | vsNorth Texas | L62-64 | 1-2 | .333 | - | ESPN+ | Joseph J. Gentile Arena · Chicago, IL |
| 4 | Thu Nov 13 | atWichita St | L74-95 | 1-3 | .250 | - | ESPN+ | Charles Koch Arena · Wichita, KS |
| 5 | Sun Nov 16 | vsColorado St | L67-80 | 1-4 | .200 | - | ESPN+ | Joseph J. Gentile Arena · Chicago, IL |
| 6 | Fri Nov 21 | vsN Illinois | L59-76 | 1-5 | .167 | - | ESPN+ | Joseph J. Gentile Arena · Chicago, IL |
| 7 | Tue Nov 25 | vsNorthern Iowa | L51-72 | 1-6 | .143 | - | CBSSN | Joseph J. Gentile Arena · Chicago, IL |
| 8 | Wed Nov 26 | vsSan Jose St | L51-63 | 1-7 | .125 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 9 | Tue Dec 2 | vsC Michigan | W83-72 | 2-7 | .222 | - | ESPN+ | Joseph J. Gentile Arena · Chicago, IL |
| 10 | Sat Dec 6 | vsPrinceton | W73-68 | 3-7 | .300 | - | USA Net | Joseph J. Gentile Arena · Chicago, IL |
| 11 | Sun Dec 14 | vsChicago St | L75-84 | 3-8 | .273 | - | ESPN+ | Joseph J. Gentile Arena · Chicago, IL |
| 12 | Wed Dec 17 | atSan Francisco | L71-85 | 3-9 | .250 | - | ESPN+ | Chase Center · San Francisco, CA |
| 13 | Sat Dec 20 | atSanta Clara | W80-78 | 4-9 | .308 | - | | Leavey Center · Santa Clara, CA |
| 14 | Wed Dec 31 | atRhode Island | W61-57 | 5-9 | .357 | - | ESPN+ | Ryan Center · Kingston, RI |
| 15 | Sat Jan 3 | vsDayton | L68-70 | 5-10 | .333 | - | CBSSN | Joseph J. Gentile Arena · Chicago, IL |
| 16 | Wed Jan 7 | vsDavidson | L64-79 | 5-11 | .313 | - | CBSSN | Joseph J. Gentile Arena · Chicago, IL |
| 17 | Sat Jan 10 | atG Washington | L66-101 | 5-12 | .294 | - | CBSSN | Charles E. Smith Center · Washington, D.C. |
| 18 | Tue Jan 13 | vsGeorge Mason | L74-82 | 5-13 | .278 | - | CBSSN | Joseph J. Gentile Arena · Chicago, IL |
| 19 | Fri Jan 16 | atDayton | L51-78 | 5-14 | .263 | - | ESPN2 | UD Arena · Dayton, OH |
| 20 | Tue Jan 20 | atSt Bonaventure | L70-84 | 5-15 | .250 | - | ESPN+ | Reilly Center · Saint Bonaventure, NY |
| 21 | Sat Jan 24 | vsDuquesne | L59-71 | 5-16 | .238 | - | ESPN+ | Joseph J. Gentile Arena · Chicago, IL |
| 22 | Tue Jan 27 | vsSaint Joseph's | L64-85 | 5-17 | .227 | - | CBSSN | Joseph J. Gentile Arena · Chicago, IL |
| 23 | Fri Jan 30 | atVCU | L75-89 | 5-18 | .217 | - | ESPN2 | Stuart C. Siegel Center · Richmond, VA |
| 24 | Tue Feb 3 | vsLa Salle | W71-61 | 6-18 | .250 | - | ESPN+ | Joseph J. Gentile Arena · Chicago, IL |
| 25 | Fri Feb 6 | atDavidson | L64-84 | 6-19 | .240 | - | CBSSN | John M. Belk Arena · Davidson, NC |
| 26 | Fri Feb 13 | vs18Saint Louis | L59-86 | 6-20 | .231 | - | ESPN2 | Joseph J. Gentile Arena · Chicago, IL |
| 27 | Wed Feb 18 | atFordham | L59-62 | 6-21 | .222 | - | ESPN+ | Rose Hill Gymnasium · Bronx, NY |
| 28 | Sat Feb 21 | atSaint Joseph's | L61-75 | 6-22 | .214 | - | ESPNU | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 29 | Sat Feb 28 | vsRichmond | W69-66 | 7-22 | .241 | - | CBSSN | Joseph J. Gentile Arena · Chicago, IL |
| 30 | Wed Mar 4 | at25Saint Louis | L65-79 | 7-23 | .233 | - | CBSSN | Chaifetz Arena · St. Louis, MO |
| 31 | Sat Mar 7 | vsG Washington | W68-62 | 8-23 | .258 | - | USA Net | Joseph J. Gentile Arena · Chicago, IL |
| 32 | Wed Mar 11 | atRichmond | W75-67 | 9-23 | .281 | - | USA Net | Robins Center · Richmond, VA |
| 33 | Thu Mar 12 | atDavidson | L59-64 (OT) | 9-24 | .273 | - | USA Net | John M. Belk Arena · Davidson, NC |
