| 3 | Sun Nov 9 | vs North Texas | 5:00 PM | 2-0 | 1.000 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 4 | Thu Nov 13 | atWichita St | 7:30 PM | 1-0 | 1.000 | - | ESPN+ | Charles Koch Arena · Wichita, KS |
| 5 | Sun Nov 16 | vsColorado St | 5:00 PM | 1-0 | 1.000 | - | ESPN+ | Joseph J. Gentile Arena · Chicago, IL |
| 6 | Fri Nov 21 | vsN Illinois | 8:00 PM | 1-1 | .500 | - | ESPN+ | Joseph J. Gentile Arena · Chicago, IL |
| 7 | Tue Nov 25 | vsNorthern Iowa | 4:00 PM | 1-0 | 1.000 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 8 | Tue Dec 2 | vsC Michigan | 8:00 PM | 1-0 | 1.000 | - | ESPN+ | Joseph J. Gentile Arena · Chicago, IL |
| 9 | Sat Dec 6 | vsPrinceton | 2:30 PM | 0-1 | .000 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 10 | Sun Dec 14 | vsChicago St | 5:00 PM | 0-2 | .000 | - | ESPN+ | Joseph J. Gentile Arena · Chicago, IL |
| 11 | Wed Dec 17 | atSan Francisco | 10:00 PM | 1-1 | .500 | - | ESPN+ | Chase Center · San Francisco, CA |
| 12 | Sat Dec 20 | atSanta Clara | 7:00 PM | 2-0 | 1.000 | - | | Leavey Center · Santa Clara, CA |
| 13 | Wed Dec 31 | atRhode Island | 12:00 PM | 1-1 | .500 | - | ESPN+ | Ryan Center · Kingston, RI |
| 14 | Sat Jan 3 | vsDayton | 2:00 PM | 2-0 | 1.000 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 15 | Wed Jan 7 | vsDavidson | 9:00 PM | 2-0 | 1.000 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 16 | Sat Jan 10 | atG Washington | 3:00 PM | 2-0 | 1.000 | - | | Charles E. Smith Center · Washington, D.C. |
| 17 | Tue Jan 13 | vsGeorge Mason | 7:00 PM | 2-0 | 1.000 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 18 | Fri Jan 16 | atDayton | 8:30 PM | 2-0 | 1.000 | - | ESPN2 | UD Arena · Dayton, OH |
| 19 | Tue Jan 20 | atSt Bonaventure | 7:00 PM | 1-0 | 1.000 | - | ESPN+ | Reilly Center · Saint Bonaventure, NY |
| 20 | Sat Jan 24 | vsDuquesne | 2:00 PM | 2-0 | 1.000 | - | ESPN+ | Joseph J. Gentile Arena · Chicago, IL |
| 21 | Tue Jan 27 | vsSaint Joseph's | 9:00 PM | 2-0 | 1.000 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 22 | Fri Jan 30 | atVCU | 9:00 PM | 1-1 | .500 | - | ESPN2 | Stuart C. Siegel Center · Richmond, VA |
| 23 | Tue Feb 3 | vsLa Salle | 7:00 PM | 2-0 | 1.000 | - | ESPN+ | Joseph J. Gentile Arena · Chicago, IL |
| 24 | Fri Feb 6 | atDavidson | 6:00 PM | 2-0 | 1.000 | - | | John M. Belk Arena · Davidson, NC |
| 25 | Fri Feb 13 | vsSaint Louis | 8:30 PM | 2-0 | 1.000 | - | ESPN2 | Joseph J. Gentile Arena · Chicago, IL |
| 26 | Wed Feb 18 | atFordham | 7:00 PM | 1-1 | .500 | - | ESPN+ | Rose Hill Gymnasium · Bronx, NY |
| 27 | Sat Feb 21 | atSaint Joseph's | 12:00 PM | 2-0 | 1.000 | - | | Michael J. Hagan '85 Arena · Philadelphia, PA |
| 28 | Sat Feb 28 | vsRichmond | 4:00 PM | 1-0 | 1.000 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 29 | Wed Mar 4 | atSaint Louis | 8:00 PM | 2-0 | 1.000 | - | | Chaifetz Arena · St. Louis, MO |
| 30 | Sat Mar 7 | vsG Washington | 2:00 PM | 2-0 | 1.000 | - | | Joseph J. Gentile Arena · Chicago, IL |
