| 1 | Tue Nov 9 | vs Coppin St | W103-45 | 1-0 | 1.000 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 2 | Sat Nov 13 | vs FGCU | W89-77 | 2-0 | 1.000 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 3 | Tue Nov 16 | vs Chicago St | W92-56 | 3-0 | 1.000 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 4 | Sat Nov 20 | vs UIC | W80-63 | 4-0 | 1.000 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 5 | Wed Nov 24 | at Michigan St | L61-63 | 4-1 | .800 | - | ESPN | Breslin Center · East Lansing, MI |
| 6 | Thu Nov 25 | vs Auburn | L53-62 | 4-2 | .667 | - | ESPN2 | Joseph J. Gentile Arena · Chicago, IL |
| 7 | Fri Nov 26 | vs Arizona St | W77-59 | 5-2 | .714 | - | ESPNEWS | Joseph J. Gentile Arena · Chicago, IL |
| 8 | Wed Dec 1 | vs Indiana St | W88-76 | 6-2 | .750 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 9 | Sat Dec 4 | at DePaul | W68-64 | 7-2 | .778 | - | FS1 | Wintrust Arena · Chicago, IL |
| 10 | Tue Dec 7 | vs TBD | W88-49 | 8-2 | .800 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 11 | Fri Dec 10 | at Vanderbilt | W69-58 | 9-2 | .818 | - | | Memorial Gymnasium (TN) · Nashville, TN |
| 14 | Wed Jan 5 | at Illinois St | PPD | 25-8 | .758 | - | | Redbird Arena · Normal, IL |
| 15 | Thu Jan 6 | at San Francisco | W79-74 | 10-2 | .833 | - | | War Memorial at the Sobrato Center · San Francisco, CA |
| 16 | Sat Jan 8 | vs Bradley | W78-71 (OT) | 11-2 | .846 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 17 | Tue Jan 11 | vs Valparaiso | W81-74 (2OT) | 12-2 | .857 | - | CBS | Joseph J. Gentile Arena · Chicago, IL |
| 18 | Sat Jan 15 | atIndiana St | W64-56 | 13-2 | .867 | - | CBS | Hulman Center · Terre Haute, IN |
| 19 | Tue Jan 18 | at Evansville | W77-48 | 14-2 | .875 | #22 | | Ford Center · Evansville, IN |
| 20 | Sat Jan 22 | vs Missouri St | L69-79 | 14-3 | .824 | #22 | CBS | Joseph J. Gentile Arena · Chicago, IL |
| 21 | Tue Jan 25 | vs S Illinois | W59-47 | 15-3 | .833 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 22 | Thu Jan 27 | atS Illinois | W44-39 | 16-3 | .842 | - | | Banterra Center · Carbondale, IL |
| 23 | Sun Jan 30 | at Drake | L68-77 | 16-4 | .800 | - | ESPN2 | The Knapp Center · Des Moines, IA |
| 24 | Wed Feb 2 | vsIllinois St | W78-64 | 17-4 | .810 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 25 | Sun Feb 6 | atMissouri St | W71-62 | 18-4 | .818 | - | ESPN2 | Great Southern Bank Arena · Springfield, MO |
| 26 | Wed Feb 9 | atBradley | L61-68 | 18-5 | .783 | - | CBS | Carver Arena · Peoria, IL |
| 27 | Sun Feb 13 | vs Northern Iowa | W85-58 | 19-5 | .792 | - | ESPN2 | Joseph J. Gentile Arena · Chicago, IL |
| 28 | Wed Feb 16 | atValparaiso | W71-69 | 20-5 | .800 | - | | Athletics-Recreation Center · Valparaiso, IN |
| 29 | Sat Feb 19 | vsDrake | L76-83 | 20-6 | .769 | - | ESPN2 | Joseph J. Gentile Arena · Chicago, IL |
| 30 | Mon Feb 21 | atIllinois St | W59-50 | 21-6 | .778 | - | | Redbird Arena · Normal, IL |
| 31 | Wed Feb 23 | vsEvansville | W82-31 | 22-6 | .786 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 32 | Sat Feb 26 | atNorthern Iowa | L96-102 (OT) | 22-7 | .759 | - | ESPNU | McLeod Center · Cedar Falls, IA |
| 33 | Fri Mar 4 | vsBradley | W66-50 | 23-7 | .767 | - | | Joseph J. Gentile Arena · Chicago, IL |
| 34 | Sat Mar 5 | atNorthern Iowa | W66-43 | 24-7 | .774 | - | CBS | McLeod Center · Cedar Falls, IA |
| 35 | Sun Mar 6 | atDrake | W64-58 | 25-7 | .781 | - | CBS | The Knapp Center · Des Moines, IA |
| 36 | Fri Mar 18 | at #7Ohio State | L41-54 | 25-8 | .758 | #10 | CBS | Value City Arena · Columbus, OH |
Norfolk St