| 1 | Mon Nov 4 | vs TBD | W96-54 | 1-0 | 1.000 | - | ESPN+ | McLeod Center · Cedar Falls, IA |
| 2 | Thu Nov 7 | vs Milwaukee | W87-68 | 2-0 | 1.000 | - | ESPN+ | McLeod Center · Cedar Falls, IA |
| 3 | Sun Nov 10 | vs UC Irvine | L60-80 | 2-1 | .667 | - | ESPN+ | McLeod Center · Cedar Falls, IA |
| 4 | Thu Nov 14 | at Wichita St | L73-79 | 2-2 | .500 | - | ESPN+ | Charles Koch Arena · Wichita, KS |
| 5 | Tue Nov 19 | vs W Illinois | W82-56 | 3-2 | .600 | - | ESPN+ | McLeod Center · Cedar Falls, IA |
| 6 | Thu Nov 28 | at North Texas | L48-68 | 3-3 | .500 | - | ESPNU | The Super Pit · Denton, TX |
| 7 | Fri Nov 29 | vs St Bonaventure | L56-68 | 3-4 | .429 | - | ESPNU | McLeod Center · Cedar Falls, IA |
| 8 | Wed Dec 4 | at UIC | W83-56 | 4-4 | .500 | - | ESPN+ | Credit Union 1 Arena · Chicago, IL |
| 9 | Sat Dec 7 | vs N Illinois | W101-57 | 5-4 | .556 | - | ESPN+ | McLeod Center · Cedar Falls, IA |
| 10 | Fri Dec 13 | vs Omaha | W78-58 | 6-4 | .600 | - | ESPN+ | McLeod Center · Cedar Falls, IA |
| 11 | Mon Dec 16 | vs Montana | W104-76 | 7-4 | .636 | - | ESPN+ | McLeod Center · Cedar Falls, IA |
| 12 | Sat Dec 21 | vs Washington St | L68-76 | 7-5 | .583 | - | | McLeod Center · Cedar Falls, IA |
| 13 | Sun Dec 29 | vs S Illinois | W78-67 | 8-5 | .615 | - | ESPN+ | McLeod Center · Cedar Falls, IA |
| 14 | Wed Jan 1 | vs Belmont | W76-70 | 9-5 | .643 | - | ESPN+ | McLeod Center · Cedar Falls, IA |
| 15 | Sat Jan 4 | at Valparaiso | L73-80 | 9-6 | .600 | - | ESPN+ | Athletics-Recreation Center · Valparaiso, IN |
| 16 | Wed Jan 8 | vs Murray St | L68-71 | 9-7 | .563 | - | ESPN+ | McLeod Center · Cedar Falls, IA |
| 17 | Sat Jan 11 | at Illinois St | W85-84 | 10-7 | .588 | - | ESPN+ | Redbird Arena · Normal, IL |
| 18 | Tue Jan 14 | vs Evansville | W73-56 | 11-7 | .611 | - | ESPN+ | McLeod Center · Cedar Falls, IA |
| 19 | Sat Jan 18 | atS Illinois | L49-73 | 11-8 | .579 | - | ESPN+ | Banterra Center · Carbondale, IL |
| 20 | Tue Jan 21 | vs Missouri St | W79-68 | 12-8 | .600 | - | ESPN+ | McLeod Center · Cedar Falls, IA |
| 21 | Sat Jan 25 | at Indiana St | W74-56 | 13-8 | .619 | - | ESPN+ | Hulman Center · Terre Haute, IN |
| 22 | Wed Jan 29 | at Drake | L52-66 | 13-9 | .591 | - | ESPN+ | The Knapp Center · Des Moines, IA |
| 23 | Sun Feb 2 | vs Bradley | W83-69 | 14-9 | .609 | - | ESPN2 | McLeod Center · Cedar Falls, IA |
| 24 | Wed Feb 5 | atMissouri St | W66-61 | 15-9 | .625 | - | ESPN+ | Great Southern Bank Arena · Springfield, MO |
| 25 | Sat Feb 8 | vsIllinois St | W68-65 | 16-9 | .640 | - | ESPNU | McLeod Center · Cedar Falls, IA |
| 26 | Tue Feb 11 | vsIndiana St | W88-73 | 17-9 | .654 | - | ESPN+ | McLeod Center · Cedar Falls, IA |
| 27 | Sun Feb 16 | atMurray St | PPD | 19-9 | .679 | - | | CFSB Center · Murray, KY |
| 28 | Mon Feb 17 | atMurray St | W74-67 | 18-9 | .667 | - | | CFSB Center · Murray, KY |
| 29 | Wed Feb 19 | atBelmont | W82-75 | 19-9 | .679 | - | ESPN+ | Curb Event Center Arena · Nashville, TN |
