| 1 | Mon Nov 4 | vs TBD | W104-46 | 1-0 | 1.000 | - | | Timmons Arena · Greenville, SC |
| 2 | Fri Nov 8 | at Belmont | W76-74 | 2-0 | 1.000 | - | ESPN+ | Curb Event Center Arena · Nashville, TN |
| 3 | Mon Nov 11 | vs Jacksonville | W78-69 | 3-0 | 1.000 | - | ESPN+ | Timmons Arena · Greenville, SC |
| 4 | Fri Nov 15 | vs Tulane | W75-67 | 4-0 | 1.000 | - | ESPN+ | Timmons Arena · Greenville, SC |
| 5 | Wed Nov 20 | vsTBD | W124-48 | 5-0 | 1.000 | - | | Timmons Arena · Greenville, SC |
| 6 | Sat Nov 23 | at Charleston So | W67-46 | 6-0 | 1.000 | - | ESPN+ | Buccaneer Fieldhouse · Charleston, SC |
| 7 | Tue Nov 26 | at Seattle U | W61-56 | 7-0 | 1.000 | - | ESPNU | Redhawk Center · Seattle, WA |
| 8 | Sat Nov 30 | at #1Kansas | L51-86 | 7-1 | .875 | - | ESPN+ | Allen Fieldhouse · Lawrence, KS |
| 9 | Wed Dec 4 | at FGCU | W76-73 | 8-1 | .889 | - | ESPN+ | Alico Arena · Fort Myers, FL |
| 10 | Sat Dec 7 | vs Princeton | W69-63 | 9-1 | .900 | - | ESPN+ | Timmons Arena · Greenville, SC |
| 11 | Sat Dec 14 | vs SC State | W68-64 | 10-1 | .909 | - | ESPN+ | Timmons Arena · Greenville, SC |
| 12 | Wed Dec 18 | vsTBD | W100-75 | 11-1 | .917 | - | | Timmons Arena · Greenville, SC |
| 13 | Sat Dec 21 | at Harvard | W77-63 | 12-1 | .923 | - | ESPN+ | Lavietes Pavilion · Cambridge, MA |
| 14 | Wed Jan 1 | at W Carolina | W90-61 | 13-1 | .929 | - | ESPN+ | Ramsey Regional Activity Center · Cullowhee, NC |
| 15 | Sat Jan 4 | at UNC Greensboro | L67-84 | 13-2 | .867 | - | ESPN+ | Greensboro Coliseum · Greensboro, NC |
| 16 | Wed Jan 8 | at The Citadel | W67-63 (OT) | 14-2 | .875 | - | ESPN+ | McAlister Field House · Charleston, SC |
| 17 | Mon Jan 13 | vs Wofford | L62-81 | 14-3 | .824 | - | ESPN+ | Timmons Arena · Greenville, SC |
| 18 | Wed Jan 15 | vs ETSU | W73-70 | 15-3 | .833 | - | ESPN+ | Timmons Arena · Greenville, SC |
| 19 | Sat Jan 18 | vs Chattanooga | L71-75 | 15-4 | .789 | - | ESPN+ | Timmons Arena · Greenville, SC |
| 20 | Wed Jan 22 | at VMI | L82-91 | 15-5 | .750 | - | ESPN+ | Cameron Hall · Lexington, VA |
| 21 | Sat Jan 25 | at Mercer | W79-74 | 16-5 | .762 | - | ESPN+ | Hawkins Arena · Macon, GA |
| 22 | Wed Jan 29 | vs Samford | W72-70 | 17-5 | .773 | - | CBS | Timmons Arena · Greenville, SC |
| 23 | Sun Feb 2 | atETSU | L69-72 | 17-6 | .739 | - | CBS | Freedom Hall Civic Center · Johnson City, TN |
| 24 | Wed Feb 5 | vsW Carolina | W84-75 (OT) | 18-6 | .750 | - | ESPN+ | Timmons Arena · Greenville, SC |
| 25 | Sat Feb 8 | atChattanooga | L72-85 | 18-7 | .720 | - | ESPN+ | McKenzie Arena · Chattanooga, TN |
| 26 | Wed Feb 12 | vsMercer | W96-72 | 19-7 | .731 | - | ESPN+ | Timmons Arena · Greenville, SC |
| 27 | Sat Feb 15 | vsUNC Greensboro | L50-58 | 19-8 | .704 | - | ESPN+ | Timmons Arena · Greenville, SC |
| 28 | Wed Feb 19 | atSamford | W80-72 | 20-8 | .714 | - | ESPN+ | Pete Hanna Center · Homewood, AL |
