| 1 | Mon Nov 4 | vs TBD | W103-54 | 1-0 | 1.000 | - | ESPN+ | Cameron Hall · Lexington, VA |
| 2 | Sat Nov 9 | at Bellarmine | W76-71 | 2-0 | 1.000 | - | ESPN+ | Knights Hall · Louisville, KY |
| 3 | Tue Nov 12 | vsTBD | W102-56 | 3-0 | 1.000 | - | ESPN+ | Cameron Hall · Lexington, VA |
| 4 | Fri Nov 15 | vs Tennessee Tech | L71-72 | 3-1 | .750 | - | | Cameron Hall · Lexington, VA |
| 5 | Sat Nov 16 | vs Charleston So | W80-69 | 4-1 | .800 | - | | Cameron Hall · Lexington, VA |
| 6 | Mon Nov 18 | at Pitt | L48-93 | 4-2 | .667 | - | ESPN+ | Petersen Events Center · Pittsburgh, PA |
| 7 | Fri Nov 22 | at Davidson | L66-93 | 4-3 | .571 | - | ESPN+ | John M. Belk Arena · Davidson, NC |
| 8 | Tue Nov 26 | at Loyola MD | L67-70 | 4-4 | .500 | - | ESPN+ | Reitz Arena · Baltimore, MD |
| 9 | Fri Nov 29 | at G Washington | L64-77 | 4-5 | .444 | - | ESPN+ | Charles E. Smith Center · Washington, D.C. |
| 10 | Tue Dec 3 | vsTBD | W113-51 | 5-5 | .500 | - | | Cameron Hall · Lexington, VA |
| 11 | Sat Dec 7 | vs Queens | L78-81 | 5-6 | .455 | - | ESPN+ | Cameron Hall · Lexington, VA |
| 12 | Thu Dec 12 | vsTBD | W100-61 | 6-6 | .500 | - | ESPN+ | Cameron Hall · Lexington, VA |
| 13 | Sat Dec 21 | at Richmond | L71-78 | 6-7 | .462 | - | ESPN+ | Robins Center · Richmond, VA |
| 14 | Wed Jan 1 | at ETSU | L69-84 | 6-8 | .429 | - | ESPN+ | Freedom Hall Civic Center · Johnson City, TN |
| 15 | Sat Jan 4 | vs Mercer | L67-70 | 6-9 | .400 | - | ESPN+ | Cameron Hall · Lexington, VA |
| 16 | Thu Jan 9 | at Samford | L68-81 | 6-10 | .375 | - | ESPN+ | Pete Hanna Center · Homewood, AL |
| 17 | Sun Jan 12 | at Chattanooga | L66-91 | 6-11 | .353 | - | ESPN+ | McKenzie Arena · Chattanooga, TN |
| 18 | Wed Jan 15 | vs W Carolina | W66-50 | 7-11 | .389 | - | ESPN+ | Cameron Hall · Lexington, VA |
| 19 | Sat Jan 18 | at The Citadel | W75-70 | 8-11 | .421 | - | ESPN+ | McAlister Field House · Charleston, SC |
| 20 | Wed Jan 22 | vs Furman | W91-82 | 9-11 | .450 | - | ESPN+ | Cameron Hall · Lexington, VA |
| 21 | Sat Jan 25 | vs UNC Greensboro | L57-60 | 9-12 | .429 | - | ESPN+ | Cameron Hall · Lexington, VA |
| 22 | Wed Jan 29 | at Wofford | W74-67 | 10-12 | .455 | - | ESPN+ | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 23 | Sat Feb 1 | atW Carolina | W80-76 (OT) | 11-12 | .478 | - | ESPN+ | Ramsey Regional Activity Center · Cullowhee, NC |
| 24 | Wed Feb 5 | vsETSU | L55-62 | 11-13 | .458 | - | ESPN+ | Cameron Hall · Lexington, VA |
| 25 | Sat Feb 8 | vsThe Citadel | W82-70 | 12-13 | .480 | - | ESPN+ | Cameron Hall · Lexington, VA |
| 26 | Wed Feb 12 | atUNC Greensboro | L54-80 | 12-14 | .462 | - | ESPN+ | Greensboro Coliseum · Greensboro, NC |
| 27 | Sat Feb 15 | atMercer | W80-71 | 13-14 | .481 | - | ESPN+ | Hawkins Arena · Macon, GA |
| 28 | Wed Feb 19 | vsWofford | L43-82 | 13-15 | .464 | - | ESPN+ | Cameron Hall · Lexington, VA |
