| 5 | Fri Nov 14 | at #18UNC | 9:00 PM | 3-0 | 1.000 | - | ACC Network | Dean E. Smith Center · Chapel Hill, NC |
| 6 | Tue Nov 18 | vsTBD | 7:30 PM | 0-0 | .000 | - | ESPN+ | McDougald-McLendon Arena · Durham, NC |
| 7 | Sat Nov 22 | atDayton | 2:00 PM | 2-1 | .667 | - | ESPN+ | UD Arena · Dayton, OH |
| 8 | Tue Nov 25 | atSC Upstate | 7:00 PM | 3-1 | .750 | - | ESPN+ | G.B. Hodge Center · Spartanburg, SC |
| 9 | Sat Nov 29 | vsTBD | 2:00 PM | 0-0 | .000 | - | | McDougald-McLendon Arena · Durham, NC |
| 10 | Wed Dec 3 | atJMU | 7:00 PM | 2-2 | .500 | - | ESPN+ | Atlantic Union Bank Center · Harrisonburg, VA |
| 11 | Sat Dec 6 | vsNC A&T | 4:00 PM | 1-1 | .500 | - | | McDougald-McLendon Arena · Durham, NC |
| 12 | Tue Dec 9 | at#9Kentucky | 7:00 PM | 2-1 | .667 | - | SEC Network | Rupp Arena · Lexington, KY |
| 13 | Wed Dec 17 | vsTBD | 7:00 PM | 0-0 | .000 | - | | McDougald-McLendon Arena · Durham, NC |
| 14 | Sat Dec 20 | vsLongwood | 2:00 PM | 2-1 | .667 | - | | McDougald-McLendon Arena · Durham, NC |
| 15 | Mon Dec 29 | atPenn State | 1:00 PM | 3-0 | 1.000 | - | BTN | Bryce Jordan Center · University Park, PA |
| 16 | Sat Jan 3 | vsNorfolk St | 4:30 PM | 2-2 | .500 | - | ESPN+ | McDougald-McLendon Arena · Durham, NC |
| 17 | Sat Jan 10 | atCoppin St | 4:30 PM | 0-4 | .000 | - | ESPN+ | Physical Education Complex · Baltimore, MD |
| 18 | Mon Jan 12 | atMorgan St | 6:00 PM | 1-2 | .333 | - | | Hill Field House · Baltimore, MD |
| 19 | Sat Jan 17 | vsHoward | 4:30 PM | 1-2 | .333 | - | ESPN+ | McDougald-McLendon Arena · Durham, NC |
| 20 | Sat Jan 24 | vsDelaware St | 4:30 PM | 0-3 | .000 | - | ESPN+ | McDougald-McLendon Arena · Durham, NC |
| 21 | Mon Jan 26 | vsMD-Eastern | 7:00 PM | 1-3 | .250 | - | ESPN+ | McDougald-McLendon Arena · Durham, NC |
| 22 | Sat Jan 31 | atSC State | 4:00 PM | 0-3 | .000 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 23 | Sat Feb 7 | atNorfolk St | TBD | 2-2 | .500 | - | | Joseph G. Echols Hall · Norfolk, VA |
| 24 | Sat Feb 14 | vsCoppin St | 4:30 PM | 0-4 | .000 | - | ESPN+ | McDougald-McLendon Arena · Durham, NC |
| 25 | Mon Feb 16 | vsMorgan St | 7:00 PM | 1-2 | .333 | - | ESPN+ | McDougald-McLendon Arena · Durham, NC |
| 26 | Sat Feb 21 | atHoward | TBD | 1-2 | .333 | - | | Burr Gymnasium · Washington, D.C. |
| 27 | Sat Feb 28 | atDelaware St | 4:00 PM | 0-3 | .000 | - | | Memorial Hall (Dover, DE) · Dover, DE |
| 28 | Mon Mar 2 | atMD-Eastern | 7:00 PM | 1-3 | .250 | - | | Hytche Athletic Center · Princess Anne, MD |
| 29 | Thu Mar 5 | vsSC State | 7:30 PM | 0-3 | .000 | - | ESPNU | McDougald-McLendon Arena · Durham, NC |
