| 1 | Mon Nov 4 | at George Mason | L58-75 | 0-1 | .000 | - | ESPN+ | EagleBank Arena · Fairfax, VA |
| 2 | Fri Nov 8 | vs Gardner-Webb | L82-88 | 0-2 | .000 | - | | McDougald-McLendon Arena · Durham, NC |
| 3 | Tue Nov 12 | at High Point | L60-76 | 0-3 | .000 | - | ESPN+ | Nido and Mariana Qubein Arena · High Point, NC |
| 4 | Fri Nov 15 | at Georgia So | L75-80 | 0-4 | .000 | - | | W.S. Hanner Fieldhouse · Statesboro, GA |
| 5 | Sat Nov 16 | at William & Mary | W78-76 | 1-4 | .200 | - | ESPN+ | Kaplan Arena · Williamsburg, VA |
| 6 | Sun Nov 17 | at Winthrop | L75-77 | 1-5 | .167 | - | ESPN+ | Winthrop Coliseum · Rock Hill, SC |
| 7 | Fri Nov 22 | at Georgia St | L79-93 | 1-6 | .143 | - | ESPN+ | GSU Convocation Center · Atlanta, GA |
| 8 | Mon Nov 25 | vs TBD | W91-36 | 2-6 | .250 | - | ESPN+ | McDougald-McLendon Arena · Durham, NC |
| 9 | Sat Nov 30 | vsTBD | W131-51 | 3-6 | .333 | - | ESPN+ | McDougald-McLendon Arena · Durham, NC |
| 10 | Thu Dec 5 | vs Radford | L67-70 | 3-7 | .300 | - | ESPN+ | McDougald-McLendon Arena · Durham, NC |
| 11 | Sat Dec 7 | atGardner-Webb | W78-77 | 4-7 | .364 | - | ESPN+ | Paul Porter Arena · Boiling Springs, NC |
| 12 | Tue Dec 10 | at West Virginia | L45-79 | 4-8 | .333 | - | ESPN+ | WVU Coliseum · Morgantown, WV |
| 13 | Sat Dec 14 | at Longwood | W77-70 | 5-8 | .385 | - | ESPN+ | Willett Hall · Farmville, VA |
| 14 | Tue Dec 17 | vsTBD | W112-67 | 6-8 | .429 | - | ESPN+ | McDougald-McLendon Arena · Durham, NC |
| 15 | Fri Dec 20 | vsLongwood | L67-82 | 6-9 | .400 | - | ESPN+ | McDougald-McLendon Arena · Durham, NC |
| 16 | Sat Dec 28 | at NC A&T | L72-85 | 6-10 | .375 | - | CBS | Corbett Sports Center · Greensboro, NC |
| 17 | Tue Dec 31 | vsTBD | W121-61 | 7-10 | .412 | - | | McDougald-McLendon Arena · Durham, NC |
| 18 | Sat Jan 4 | at Coppin St | L61-63 | 7-11 | .389 | - | ESPN+ | Physical Education Complex · Baltimore, MD |
| 19 | Tue Jan 7 | at Morgan St | L98-102 (2OT) | 7-12 | .368 | - | ESPN+ | Hill Field House · Baltimore, MD |
| 20 | Sat Jan 11 | vs MD-Eastern | W88-69 | 8-12 | .400 | - | ESPN+ | McDougald-McLendon Arena · Durham, NC |
| 21 | Mon Jan 13 | vs Delaware St | W75-72 | 9-12 | .429 | - | ESPN+ | McDougald-McLendon Arena · Durham, NC |
| 22 | Sat Jan 25 | vs SC State | W82-77 | 10-12 | .455 | - | ESPN+ | McDougald-McLendon Arena · Durham, NC |
| 23 | Mon Feb 3 | at Norfolk St | L78-81 | 10-13 | .435 | - | ESPNU | Joseph G. Echols Hall · Norfolk, VA |
| 24 | Sat Feb 8 | at Howard | L78-82 | 10-14 | .417 | - | ESPN+ | Burr Gymnasium · Washington, D.C. |
| 25 | Sat Feb 15 | vsCoppin St | W71-59 | 11-14 | .440 | - | ESPN+ | McDougald-McLendon Arena · Durham, NC |
| 26 | Mon Feb 17 | vsMorgan St | L78-92 | 11-15 | .423 | - | ESPN+ | McDougald-McLendon Arena · Durham, NC |
| 27 | Mon Feb 24 | atDelaware St | L84-86 (OT) | 11-16 | .407 | - | ESPN+ | Memorial Hall (Dover, DE) · Dover, DE |
| 28 | Wed Feb 26 | atMD-Eastern | L59-68 | 11-17 | .393 | - | | Hytche Athletic Center · Princess Anne, MD |
| 29 | Sat Mar 1 | vsHoward | W72-68 | 12-17 | .414 | - | ESPN+ | McDougald-McLendon Arena · Durham, NC |
| 30 | Mon Mar 3 | vsNorfolk St | W91-87 (OT) | 13-17 | .433 | - | ESPN+ | McDougald-McLendon Arena · Durham, NC |
| 31 | Thu Mar 6 | atSC State | L71-87 | 13-18 | .419 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 32 | Thu Mar 13 | atDelaware St | W79-77 | 14-18 | .438 | - | ESPN+ | Memorial Hall (Dover, DE) · Dover, DE |
| 33 | Fri Mar 14 | atSC State | L67-88 | 14-19 | .424 | - | ESPN+ | S-H-M Memorial Center · Orangeburg, SC |
