| 1 | Wed Nov 25 | at Iowa | L67-97 | 0-1 | .000 | - | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 2 | Thu Nov 26 | vsSouthern | W85-78 (OT) | 1-1 | .500 | - | | McDougald-McLendon Arena · Durham, NC |
| 4 | Mon Dec 7 | atCoast Car | L71-78 | 1-2 | .333 | - | | The HTC Center · Conway, SC |
| 6 | Sat Dec 12 | at#16UNC | L67-73 | 1-3 | .250 | - | | Dean E. Smith Center · Chapel Hill, NC |
| 8 | Sat Jan 9 | atFAMU | PPD | 5-9 | .357 | - | | Al Lawson Center · Tallahassee, FL |
| 9 | Sat Jan 16 | vsSC State | PPD | 5-9 | .357 | - | | McDougald-McLendon Arena · Durham, NC |
| 10 | Sun Jan 17 | vsSC State | PPD | 5-9 | .357 | - | | McDougald-McLendon Arena · Durham, NC |
| 11 | Sat Jan 23 | vsNC A&T | PPD | 5-9 | .357 | - | | McDougald-McLendon Arena · Durham, NC |
| 13 | Fri Jan 29 | vsTBD | W94-61 | 2-3 | .400 | - | | McDougald-McLendon Arena · Durham, NC |
| 15 | Mon Feb 1 | vsSC State | W91-77 | 3-3 | .500 | - | ESPN2 | McDougald-McLendon Arena · Durham, NC |
| 16 | Tue Feb 2 | vsSC State | W64-63 | 4-3 | .571 | - | | McDougald-McLendon Arena · Durham, NC |
| 17 | Mon Feb 8 | atFAMU | L50-59 | 4-4 | .500 | - | | Al Lawson Center · Tallahassee, FL |
| 18 | Tue Feb 9 | atFAMU | L47-60 | 4-5 | .444 | - | | Al Lawson Center · Tallahassee, FL |
| 21 | Wed Feb 24 | vsNC A&T | L63-79 | 4-6 | .400 | - | ESPNU | McDougald-McLendon Arena · Durham, NC |
| 22 | Sat Feb 27 | atNC A&T | L53-55 | 4-7 | .364 | - | ESPNU | Corbett Sports Center · Greensboro, NC |
| 23 | Wed Mar 3 | vsFAMU | L58-65 | 4-8 | .333 | - | | McDougald-McLendon Arena · Durham, NC |
| 24 | Thu Mar 4 | vsFAMU | W74-71 | 5-8 | .385 | - | | McDougald-McLendon Arena · Durham, NC |
| 25 | Thu Mar 11 | atNorfolk St | L58-87 | 5-9 | .357 | - | | Joseph G. Echols Hall · Norfolk, VA |
