| 1 | Mon Nov 7 | at #18Virginia | L61-73 | 0-1 | .000 | - | | John Paul Jones Arena · Charlottesville, VA |
| 2 | Thu Nov 10 | at Appalachian St | L74-79 (OT) | 0-2 | .000 | - | | Holmes Convocation Center · Boone, NC |
| 3 | Mon Nov 14 | at Liberty | L63-79 | 0-3 | .000 | - | | Liberty Arena · Lynchburg, VA |
| 4 | Wed Nov 16 | vs TBD | W109-50 | 1-3 | .250 | - | | McDougald-McLendon Arena · Durham, NC |
| 5 | Sun Nov 20 | vsTBD | W86-70 | 2-3 | .400 | - | | McDougald-McLendon Arena · Durham, NC |
| 6 | Sat Nov 26 | vs Gardner-Webb | W58-53 | 3-3 | .500 | - | | McDougald-McLendon Arena · Durham, NC |
| 7 | Tue Nov 29 | vs UNC Asheville | W79-66 | 4-3 | .571 | - | | McDougald-McLendon Arena · Durham, NC |
| 8 | Thu Dec 1 | at Radford | L78-80 | 4-4 | .500 | - | | Donald N. Dedmon Center · Radford, VA |
| 9 | Sat Dec 3 | vsTBD | W127-40 | 5-4 | .556 | - | | McDougald-McLendon Arena · Durham, NC |
| 10 | Tue Dec 6 | at Marquette | L78-90 | 5-5 | .500 | - | FS1 | Fiserv Forum · Milwaukee, WI |
| 11 | Tue Dec 13 | at LSU | L57-67 | 5-6 | .455 | - | SEC Network | Pete Maravich Assembly Center · Baton Rouge, LA |
| 12 | Sat Dec 17 | atGardner-Webb | L70-72 | 5-7 | .417 | - | | Paul Porter Arena · Boiling Springs, NC |
| 13 | Tue Dec 20 | vs The Citadel | W81-74 | 6-7 | .462 | - | | McDougald-McLendon Arena · Durham, NC |
| 14 | Tue Jan 3 | vsTBD | W98-52 | 7-7 | .500 | - | | McDougald-McLendon Arena · Durham, NC |
| 15 | Sat Jan 7 | at Morgan St | L73-78 (OT) | 7-8 | .467 | - | | Hill Field House · Baltimore, MD |
| 16 | Mon Jan 9 | at Coppin St | W64-59 | 8-8 | .500 | - | | Physical Education Complex · Baltimore, MD |
| 17 | Sat Jan 14 | vs SC State | W71-67 | 9-8 | .529 | - | | McDougald-McLendon Arena · Durham, NC |
| 18 | Sat Jan 21 | vs Delaware St | W74-55 | 10-8 | .556 | - | | McDougald-McLendon Arena · Durham, NC |
| 19 | Mon Jan 23 | vs MD-Eastern | L58-59 | 10-9 | .526 | - | | McDougald-McLendon Arena · Durham, NC |
| 20 | Sat Jan 28 | at Howard | L67-71 | 10-10 | .500 | - | ESPNU | Burr Gymnasium · Washington, D.C. |
| 21 | Mon Jan 30 | at Norfolk St | L71-77 | 10-11 | .476 | - | ESPNU | Joseph G. Echols Hall · Norfolk, VA |
| 22 | Sat Feb 11 | vsMorgan St | W83-63 | 11-11 | .500 | - | | McDougald-McLendon Arena · Durham, NC |
| 23 | Mon Feb 13 | vsCoppin St | W85-52 | 12-11 | .522 | - | | McDougald-McLendon Arena · Durham, NC |
| 24 | Sat Feb 18 | atDelaware St | W66-58 | 13-11 | .542 | - | | Memorial Hall (Dover, DE) · Dover, DE |
| 25 | Mon Feb 20 | atMD-Eastern | W68-63 | 14-11 | .560 | - | | Hytche Athletic Center · Princess Anne, MD |
| 26 | Sat Feb 25 | vsHoward | W68-60 | 15-11 | .577 | - | | McDougald-McLendon Arena · Durham, NC |
| 27 | Mon Feb 27 | vsNorfolk St | W76-75 (OT) | 16-11 | .593 | - | | McDougald-McLendon Arena · Durham, NC |
| 28 | Thu Mar 2 | atSC State | W71-64 | 17-11 | .607 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 29 | Wed Mar 8 | vsDelaware St | W89-59 | 18-11 | .621 | - | | McDougald-McLendon Arena · Durham, NC |
| 30 | Fri Mar 10 | vsNorfolk St | L65-72 (OT) | 18-12 | .600 | - | | McDougald-McLendon Arena · Durham, NC |
