| 1 | Sat Nov 9 | at SF Austin | L64-94 | 0-1 | .000 | - | | William R. Johnson Coliseum · Nacogdoches, TX |
| 2 | Mon Nov 11 | vsSC Upstate | W73-64 | 1-1 | .500 | - | | McDougald-McLendon Arena · Durham, NC |
| 3 | Fri Nov 15 | atAkron | L47-57 | 1-2 | .333 | - | | James A. Rhodes Arena · Akron, OH |
| 4 | Sun Nov 17 | atLouisville | L58-87 | 1-3 | .250 | - | ACC Network | KFC Yum! Center · Louisville, KY |
| 5 | Tue Nov 19 | atYoungstown St | L60-66 | 1-4 | .200 | - | | Beeghly Center · Youngstown, OH |
| 6 | Thu Nov 21 | vsTBD | W68-44 | 2-4 | .333 | - | | McDougald-McLendon Arena · Durham, NC |
| 7 | Tue Nov 26 | atS Illinois | L48-64 | 2-5 | .286 | - | | Banterra Center · Carbondale, IL |
| 8 | Mon Dec 2 | atWofford | L59-77 | 2-6 | .250 | - | | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 9 | Wed Dec 4 | atGeorgia | L59-95 | 2-7 | .222 | - | | Stegeman Coliseum · Athens, GA |
| 10 | Sat Dec 7 | atCharleston So | L53-58 | 2-8 | .200 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 11 | Wed Dec 11 | vsTBD | W109-28 | 3-8 | .273 | - | | McDougald-McLendon Arena · Durham, NC |
| 12 | Sat Dec 14 | atCoast Car | L71-91 | 3-9 | .250 | - | | The HTC Center · Conway, SC |
| 13 | Tue Dec 17 | atLouisiana Tech | L60-69 | 3-10 | .231 | - | | Thomas Assembly Center · Ruston, LA |
| 14 | Mon Dec 30 | vsTBD | W108-63 | 4-10 | .286 | - | | McDougald-McLendon Arena · Durham, NC |
| 15 | Sat Jan 4 | vsFAMU | W61-45 | 5-10 | .333 | - | | McDougald-McLendon Arena · Durham, NC |
| 16 | Sat Jan 11 | atDelaware St | L66-68 | 5-11 | .313 | - | | Memorial Hall (Dover, DE) · Dover, DE |
| 17 | Mon Jan 13 | atMD-Eastern | W69-64 (OT) | 6-11 | .353 | - | | Hytche Athletic Center · Princess Anne, MD |
| 18 | Sat Jan 18 | atBethune | W86-59 | 7-11 | .389 | - | | Moore Gymnasium (FL) · Daytona Beach, FL |
| 19 | Mon Jan 20 | atFAMU | L57-66 | 7-12 | .368 | - | | Al Lawson Center · Tallahassee, FL |
| 20 | Sat Jan 25 | vsDelaware St | W72-45 | 8-12 | .400 | - | | McDougald-McLendon Arena · Durham, NC |
| 21 | Sat Feb 1 | vsSC State | W73-56 | 9-12 | .429 | - | | McDougald-McLendon Arena · Durham, NC |
| 22 | Mon Feb 3 | vsNorfolk St | W69-63 | 10-12 | .455 | - | ESPNU | McDougald-McLendon Arena · Durham, NC |
| 23 | Sat Feb 8 | atCoppin St | W68-63 | 11-12 | .478 | - | | Physical Education Complex · Baltimore, MD |
| 24 | Mon Feb 10 | atMorgan St | W58-57 | 12-12 | .500 | - | | Hill Field House · Baltimore, MD |
| 25 | Mon Feb 17 | atNC A&T | L60-77 | 12-13 | .480 | - | ESPNU | Corbett Sports Center · Greensboro, NC |
| 26 | Sat Feb 22 | vsMD-Eastern | W74-55 | 13-13 | .500 | - | | McDougald-McLendon Arena · Durham, NC |
| 27 | Mon Feb 24 | vsHoward | W80-65 | 14-13 | .519 | - | | McDougald-McLendon Arena · Durham, NC |
| 28 | Sat Feb 29 | atSC State | W83-82 (2OT) | 15-13 | .536 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 29 | Mon Mar 2 | vsBethune | W71-68 (OT) | 16-13 | .552 | - | | McDougald-McLendon Arena · Durham, NC |
| 30 | Thu Mar 5 | vsNC A&T | W86-80 | 17-13 | .567 | - | ESPNU | McDougald-McLendon Arena · Durham, NC |
| 31 | Wed Mar 11 | vsDelaware St | W92-75 | 18-13 | .581 | - | | McDougald-McLendon Arena · Durham, NC |
