| 1 | Mon Nov 3 | at NC State | L66-114 | 0-1 | .000 | - | ACC Extra | PNC Arena · Raleigh, NC |
| 2 | Fri Nov 7 | atVirginia | L62-81 | 0-2 | .000 | - | ACC Extra | John Paul Jones Arena · Charlottesville, VA |
| 3 | Sun Nov 9 | atAppalachian St | L54-76 | 0-3 | .000 | - | ESPN+ | Holmes Convocation Center · Boone, NC |
| 4 | Wed Nov 12 | vsTBD | W77-61 | 1-3 | .250 | - | ESPN+ | McDougald-McLendon Arena · Durham, NC |
| 5 | Fri Nov 14 | at18UNC | L53-97 | 1-4 | .200 | - | ACC Network | Dean E. Smith Center · Chapel Hill, NC |
| 6 | Tue Nov 18 | vsTBD | W123-67 | 2-4 | .333 | - | ESPN+ | McDougald-McLendon Arena · Durham, NC |
| 7 | Sat Nov 22 | atDayton | L55-74 | 2-5 | .286 | - | ESPN+ | UD Arena · Dayton, OH |
| 8 | Tue Nov 25 | atSC Upstate | L67-82 | 2-6 | .250 | - | ESPN+ | G.B. Hodge Center · Spartanburg, SC |
| 9 | Sat Nov 29 | vsTBD | W109-61 | 3-6 | .333 | - | | McDougald-McLendon Arena · Durham, NC |
| 10 | Wed Dec 3 | atJMU | L62-67 | 3-7 | .300 | - | ESPN+ | Atlantic Union Bank Center · Harrisonburg, VA |
| 11 | Sat Dec 6 | vsNC A&T | L54-69 | 3-8 | .273 | - | ESPN+ | McDougald-McLendon Arena · Durham, NC |
| 12 | Tue Dec 9 | atKentucky | L67-103 | 3-9 | .250 | - | SEC Network | Rupp Arena · Lexington, KY |
| 13 | Wed Dec 17 | vsTBD | W96-62 | 4-9 | .308 | - | | McDougald-McLendon Arena · Durham, NC |
| 14 | Sat Dec 20 | vsLongwood | L72-74 | 4-10 | .286 | - | | McDougald-McLendon Arena · Durham, NC |
| 15 | Mon Dec 29 | atPenn State | L67-90 | 4-11 | .267 | - | BTN | Bryce Jordan Center · University Park, PA |
| 16 | Sat Jan 3 | vsNorfolk St | W69-67 | 5-11 | .313 | - | ESPN+ | McDougald-McLendon Arena · Durham, NC |
| 17 | Sat Jan 10 | atCoppin St | W88-77 | 6-11 | .353 | - | ESPN+ | Physical Education Complex · Baltimore, MD |
| 18 | Mon Jan 12 | atMorgan St | W89-78 | 7-11 | .389 | - | | Hill Field House · Baltimore, MD |
| 19 | Sat Jan 17 | vsHoward | L69-83 | 7-12 | .368 | - | ESPN+ | McDougald-McLendon Arena · Durham, NC |
| 20 | Sat Jan 24 | vsDelaware St | PPD | 11-16 | .407 | - | | McDougald-McLendon Arena · Durham, NC |
| 21 | Sat Jan 31 | atSC State | PPD | 11-16 | .407 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 22 | Mon Feb 2 | vsMD-Eastern | W65-63 | 8-12 | .400 | - | ESPN+ | McDougald-McLendon Arena · Durham, NC |
| 23 | Sat Feb 7 | atNorfolk St | L68-75 | 8-13 | .381 | - | ESPN+ | Joseph G. Echols Hall · Norfolk, VA |
| 24 | Mon Feb 9 | vsDelaware St | W72-63 | 9-13 | .409 | - | ESPN+ | McDougald-McLendon Arena · Durham, NC |
| 25 | Sat Feb 14 | vsCoppin St | L56-58 | 9-14 | .391 | - | ESPN+ | McDougald-McLendon Arena · Durham, NC |
| 26 | Mon Feb 16 | vsMorgan St | W80-76 | 10-14 | .417 | - | ESPN+ | McDougald-McLendon Arena · Durham, NC |
| 27 | Wed Feb 18 | atSC State | L72-85 | 10-15 | .400 | - | ESPN+ | S-H-M Memorial Center · Orangeburg, SC |
| 28 | Sat Feb 21 | atHoward | L67-100 | 10-16 | .385 | - | ESPN+ | Burr Gymnasium · Washington, D.C. |
| 29 | Sat Feb 28 | atDelaware St | W74-60 | 11-16 | .407 | - | ESPN+ | Memorial Hall (Dover, DE) · Dover, DE |
