| 1 | Mon Nov 3 | vs C Arkansas | 7:00 PM | 9-24 | .273 | #25 | ACC Network | Dean E. Smith Center · Chapel Hill, NC |
| 2 | Fri Nov 7 | vs#19Kansas | 7:00 PM | 21-13 | .618 | #25 | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 3 | Tue Nov 11 | vsRadford | 7:00 PM | 20-13 | .606 | #25 | ACC Network | Dean E. Smith Center · Chapel Hill, NC |
| 4 | Fri Nov 14 | vsNC Central | 9:00 PM | 14-19 | .424 | #25 | ACC Network | Dean E. Smith Center · Chapel Hill, NC |
| 5 | Tue Nov 18 | vsNavy | 7:00 PM | 15-19 | .441 | #25 | ACC Network | Dean E. Smith Center · Chapel Hill, NC |
| 6 | Tue Nov 25 | vsSt Bonaventure | 6:00 PM | 22-12 | .647 | #25 | FS1 | Dean E. Smith Center · Chapel Hill, NC |
| 7 | Thu Nov 27 | at#22Michigan St | 4:30 PM | 30-7 | .811 | #25 | FOX | Breslin Center · East Lansing, MI |
| 8 | Tue Dec 2 | at#9Kentucky | 9:30 PM | 24-12 | .667 | #25 | ESPN | Rupp Arena · Lexington, KY |
| 9 | Sun Dec 7 | vsGeorgetown | 5:00 PM | 18-16 | .529 | #25 | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 10 | Sat Dec 13 | vsSC Upstate | TBD | 6-26 | .188 | #25 | | Dean E. Smith Center · Chapel Hill, NC |
| 11 | Tue Dec 16 | vsETSU | 8:00 PM | 19-13 | .594 | #25 | ACC Network | Dean E. Smith Center · Chapel Hill, NC |
| 12 | Sat Dec 20 | vsOhio State | 3:00 PM | 17-15 | .531 | #25 | | State Farm Arena · Atlanta, GA |
| 13 | Mon Dec 22 | vsE Carolina | 8:00 PM | 19-14 | .576 | #25 | ACC Network | Dean E. Smith Center · Chapel Hill, NC |
| 14 | Tue Dec 30 | vsFlorida St | 7:00 PM | 17-15 | .531 | #25 | ESPN2 | Dean E. Smith Center · Chapel Hill, NC |
| 15 | Sat Jan 3 | atSMU | TBD | 24-11 | .686 | #25 | | Moody Coliseum · Dallas, TX |
| 16 | Sat Jan 10 | vsWake Forest | 6:00 PM | 21-11 | .656 | #25 | ACC Network | Dean E. Smith Center · Chapel Hill, NC |
| 17 | Wed Jan 14 | atStanford | 9:00 PM | 21-14 | .600 | #25 | ACC Network | Maples Pavilion · Stanford, CA |
| 18 | Sat Jan 17 | atCalifornia | 4:00 PM | 14-19 | .424 | #25 | ACC Network | Haas Pavilion · Berkeley, CA |
| 19 | Wed Jan 21 | vsNotre Dame | 7:00 PM | 15-18 | .455 | #25 | ESPN2 | Dean E. Smith Center · Chapel Hill, NC |
| 20 | Sat Jan 24 | atVirginia | TBD | 15-17 | .469 | #25 | | John Paul Jones Arena · Charlottesville, VA |
| 21 | Sat Jan 31 | atGeorgia Tech | 2:00 PM | 17-17 | .500 | #25 | ACC Network | McCamish Pavilion · Atlanta, GA |
| 22 | Mon Feb 2 | vsSyracuse | 7:00 PM | 14-19 | .424 | #25 | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 23 | Sat Feb 7 | vs#6Duke | 6:30 PM | 35-4 | .897 | #25 | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 24 | Tue Feb 10 | atMiami | 7:00 PM | 7-24 | .226 | #25 | | Watsco Center · Coral Gables, FL |
| 25 | Sat Feb 14 | vsPitt | 2:00 PM | 17-15 | .531 | #25 | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 26 | Tue Feb 17 | atNC State | TBD | 12-19 | .387 | #25 | | PNC Arena · Raleigh, NC |
| 27 | Sat Feb 21 | atSyracuse | 1:00 PM | 14-19 | .424 | #25 | ABC | JMA Wireless Dome · Syracuse, NY |
| 28 | Mon Feb 23 | vs#11Louisville | 7:00 PM | 27-8 | .771 | #25 | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 29 | Sat Feb 28 | vsVirginia Tech | TBD | 13-19 | .406 | #25 | | Dean E. Smith Center · Chapel Hill, NC |
| 30 | Tue Mar 3 | vsClemson | TBD | 27-7 | .794 | #25 | | Dean E. Smith Center · Chapel Hill, NC |
| 31 | Sat Mar 7 | at#6Duke | 6:30 PM | 35-4 | .897 | #25 | ESPN | Cameron Indoor Stadium · Durham, NC |
