| Wed Nov 27 | at #16Indiana | 12:00 PM | 4-0 | 1.000 | Simon Skjodt Assembly Hall · Bloomington, IN |
| Tue Dec 3 | vs Ole Miss | 9:00 PM | 5-0 | 1.000 | KFC Yum! Center · Louisville, KY |
| Sun Dec 8 | vs #12Duke | 6:00 PM | 4-1 | .800 | KFC Yum! Center · Louisville, KY |
| Wed Dec 11 | vs UTEP | 7:00 PM | 3-1 | .750 | KFC Yum! Center · Louisville, KY |
| Sat Dec 14 | at #9Kentucky | 5:15 PM | 5-0 | 1.000 | Rupp Arena · Lexington, KY |
| Sat Dec 21 | at Florida St | 2:00 PM | 6-1 | .857 | Donald L. Tucker Center · Tallahassee, FL |
| Sat Dec 28 | vs E Kentucky | 12:00 PM | 3-1 | .750 | KFC Yum! Center · Louisville, KY |
| Wed Jan 1 | vs #10UNC | 12:00 AM | 3-1 | .750 | KFC Yum! Center · Louisville, KY |
| Sat Jan 4 | at Virginia | 4:00 PM | 3-2 | .600 | John Paul Jones Arena · Charlottesville, VA |
| Tue Jan 7 | vs Clemson | 7:00 PM | 4-1 | .800 | KFC Yum! Center · Louisville, KY |
| Sat Jan 11 | at Pitt | 12:00 PM | 6-1 | .857 | Petersen Events Center · Pittsburgh, PA |
| Tue Jan 14 | at Syracuse | 7:00 PM | 3-2 | .600 | JMA Wireless Dome · Syracuse, NY |
| Sat Jan 18 | vsVirginia | 12:00 AM | 3-2 | .600 | KFC Yum! Center · Louisville, KY |
| Tue Jan 21 | at SMU | 9:00 PM | 4-2 | .667 | Moody Coliseum · Dallas, TX |
| Tue Jan 28 | vs Wake Forest | 7:00 PM | 6-1 | .857 | KFC Yum! Center · Louisville, KY |
| Sat Feb 1 | at Georgia Tech | 3:45 PM | 2-3 | .400 | McCamish Pavilion · Atlanta, GA |
| Wed Feb 5 | at Boston College | 7:00 PM | 4-1 | .800 | Silvio O. Conte Forum · Chestnut Hill, MA |
| Sat Feb 8 | vs Miami | 2:00 PM | 3-3 | .500 | KFC Yum! Center · Louisville, KY |
| Wed Feb 12 | at NC State | 7:00 PM | 5-0 | 1.000 | PNC Arena · Raleigh, NC |
| Sun Feb 16 | at Notre Dame | 8:00 PM | 4-1 | .800 | Purcell Pavilion · South Bend, IN |
| Sat Feb 22 | vsFlorida St | 12:00 PM | 6-1 | .857 | KFC Yum! Center · Louisville, KY |
| Tue Feb 25 | at Virginia Tech | 9:00 PM | 3-2 | .600 | Cassell Coliseum · Blacksburg, VA |
| Sat Mar 1 | vsPitt | 6:00 PM | 6-1 | .857 | KFC Yum! Center · Louisville, KY |
| Wed Mar 5 | vs California | 9:00 PM | 5-1 | .833 | KFC Yum! Center · Louisville, KY |
| Sat Mar 8 | vs Stanford | 2:00 PM | 6-0 | 1.000 | KFC Yum! Center · Louisville, KY |
Winthrop
Bellarmine
#12Tennessee
Morehead St