| 1 | Wed Nov 9 | vs Bellarmine | L66-67 | 0-1 | .000 | - | ACC Network | KFC Yum! Center · Louisville, KY |
| 2 | Sat Nov 12 | vs Wright St | L72-73 | 0-2 | .000 | - | | KFC Yum! Center · Louisville, KY |
| 3 | Tue Nov 15 | vs Appalachian St | L60-61 | 0-3 | .000 | - | ACC Network | KFC Yum! Center · Louisville, KY |
| 4 | Mon Nov 21 | at Arkansas | L54-80 | 0-4 | .000 | - | ESPN2 | Bud Walton Arena · Fayetteville, AR |
| 5 | Tue Nov 22 | vs Texas Tech | L38-70 | 0-5 | .000 | - | ESPN2 | KFC Yum! Center · Louisville, KY |
| 6 | Wed Nov 23 | at Cincinnati | L62-81 | 0-6 | .000 | - | ESPNU | Fifth Third Arena · Cincinnati, OH |
| 7 | Tue Nov 29 | vs Maryland | L54-79 | 0-7 | .000 | - | ESPN2 | KFC Yum! Center · Louisville, KY |
| 8 | Sun Dec 4 | vs Miami | L53-80 | 0-8 | .000 | - | ACC Network | KFC Yum! Center · Louisville, KY |
| 9 | Sat Dec 10 | at Florida St | L53-75 | 0-9 | .000 | - | ACC Network | Donald L. Tucker Center · Tallahassee, FL |
| 10 | Wed Dec 14 | vs Western KY | W94-83 | 1-9 | .100 | - | ESPN2 | KFC Yum! Center · Louisville, KY |
| 11 | Sat Dec 17 | vs FAMU | W61-55 | 2-9 | .182 | - | | KFC Yum! Center · Louisville, KY |
| 12 | Tue Dec 20 | vs Lipscomb | L67-75 | 2-10 | .167 | - | | KFC Yum! Center · Louisville, KY |
| 13 | Thu Dec 22 | at NC State | L64-76 | 2-11 | .154 | - | ACC Network | PNC Arena · Raleigh, NC |
| 14 | Sat Dec 31 | at #19Kentucky | L63-86 | 2-12 | .143 | - | CBS | Rupp Arena · Lexington, KY |
| 15 | Tue Jan 3 | vs Syracuse | L69-70 | 2-13 | .133 | - | ESPNEWS | KFC Yum! Center · Louisville, KY |
| 16 | Sat Jan 7 | vs Wake Forest | L72-80 | 2-14 | .125 | - | ACC Network | KFC Yum! Center · Louisville, KY |
| 17 | Wed Jan 11 | at Clemson | L70-83 | 2-15 | .118 | - | | Littlejohn Coliseum · Clemson, SC |
| 18 | Sat Jan 14 | vs UNC | L59-80 | 2-16 | .111 | - | ESPN | KFC Yum! Center · Louisville, KY |
| 19 | Wed Jan 18 | vs Pitt | L54-75 | 2-17 | .105 | - | ACC Network | KFC Yum! Center · Louisville, KY |
| 20 | Wed Jan 25 | at Boston College | L65-75 | 2-18 | .100 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 21 | Sat Jan 28 | at Notre Dame | L62-76 | 2-19 | .095 | - | ESPN2 | Purcell Pavilion · South Bend, IN |
| 22 | Wed Feb 1 | vs Georgia Tech | W68-58 | 3-19 | .136 | - | | KFC Yum! Center · Louisville, KY |
| 23 | Sat Feb 4 | vsFlorida St | L78-81 | 3-20 | .130 | - | ESPN2 | KFC Yum! Center · Louisville, KY |
| 24 | Tue Feb 7 | atPitt | L57-91 | 3-21 | .125 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 25 | Sat Feb 11 | at#19Miami | L85-93 | 3-22 | .120 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 26 | Wed Feb 15 | vs #7Virginia | L58-61 | 3-23 | .115 | - | ESPNU | KFC Yum! Center · Louisville, KY |
| 27 | Sat Feb 18 | vsClemson | W83-73 | 4-23 | .148 | - | ACC Network | KFC Yum! Center · Louisville, KY |
| 28 | Mon Feb 20 | at Duke | L62-79 | 4-24 | .143 | - | ESPN | Cameron Indoor Stadium · Durham, NC |
| 29 | Sat Feb 25 | atGeorgia Tech | L67-83 | 4-25 | .138 | - | | McCamish Pavilion · Atlanta, GA |
| 30 | Tue Feb 28 | vs Virginia Tech | L54-71 | 4-26 | .133 | - | ACC Network | KFC Yum! Center · Louisville, KY |
| 31 | Sat Mar 4 | at#13Virginia | L60-75 | 4-27 | .129 | - | ESPN2 | John Paul Jones Arena · Charlottesville, VA |
| 32 | Tue Mar 7 | atBoston College | L62-80 | 4-28 | .125 | - | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
