| 9 | Sat Dec 6 | at #22Indiana | 2:00 PM | 7-1 | .875 | #6 | CBS | Simon Skjodt Assembly Hall · Bloomington, IN |
| 10 | Sat Dec 13 | vsMemphis | 3:30 PM | 3-4 | .429 | #6 | ESPN | KFC Yum! Center · Louisville, KY |
| 11 | Tue Dec 16 | at#13Tennessee | 7:00 PM | 7-2 | .778 | #6 | ESPN | Thompson-Boling Arena · Knoxville, TN |
| 12 | Sat Dec 20 | vsMontana | 12:00 PM | 4-5 | .444 | #6 | ACC Network | KFC Yum! Center · Louisville, KY |
| 13 | Tue Dec 30 | atCalifornia | 9:00 PM | 7-1 | .875 | #6 | ACC Network | Haas Pavilion · Berkeley, CA |
| 14 | Fri Jan 2 | atStanford | 8:00 PM | 7-1 | .875 | #6 | ACC Network | Maples Pavilion · Stanford, CA |
| 15 | Tue Jan 6 | vs#4Duke | 7:00 PM | 9-0 | 1.000 | #6 | ESPN | KFC Yum! Center · Louisville, KY |
| 16 | Sat Jan 10 | vsBoston College | 12:00 PM | 4-5 | .444 | #6 | | KFC Yum! Center · Louisville, KY |
| 17 | Tue Jan 13 | vsVirginia | 7:00 PM | 7-1 | .875 | #6 | | KFC Yum! Center · Louisville, KY |
| 18 | Sat Jan 17 | atPitt | 8:00 PM | 5-4 | .556 | #6 | | Petersen Events Center · Pittsburgh, PA |
| 19 | Sat Jan 24 | vsVirginia Tech | 3:30 PM | 7-2 | .778 | #6 | | KFC Yum! Center · Louisville, KY |
| 20 | Mon Jan 26 | at#4Duke | 7:00 PM | 9-0 | 1.000 | #6 | ESPN | Cameron Indoor Stadium · Durham, NC |
| 21 | Sat Jan 31 | vsSMU | 2:00 PM | 8-1 | .889 | #6 | | KFC Yum! Center · Louisville, KY |
| 22 | Wed Feb 4 | vsNotre Dame | 7:00 PM | 6-3 | .667 | #6 | ESPN2 | KFC Yum! Center · Louisville, KY |
| 23 | Sat Feb 7 | atWake Forest | 12:00 PM | 6-3 | .667 | #6 | ACC Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 24 | Mon Feb 9 | vsNC State | 7:00 PM | 5-3 | .625 | #6 | ESPN | KFC Yum! Center · Louisville, KY |
| 25 | Sat Feb 14 | atBaylor | 4:00 PM | 6-1 | .857 | #6 | ESPN | Ferrell Center · Waco, TX |
| 26 | Tue Feb 17 | atSMU | 7:00 PM | 8-1 | .889 | #6 | | Moody Coliseum · Dallas, TX |
| 27 | Sat Feb 21 | vsGeorgia Tech | 2:15 PM | 5-4 | .556 | #6 | The CW Network | KFC Yum! Center · Louisville, KY |
| 28 | Mon Feb 23 | at#16UNC | 7:00 PM | 7-1 | .875 | #6 | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 29 | Sat Feb 28 | atClemson | TBD | 7-2 | .778 | #6 | | Littlejohn Coliseum · Clemson, SC |
| 30 | Tue Mar 3 | vsSyracuse | 9:00 PM | 5-3 | .625 | #6 | ACC Network | KFC Yum! Center · Louisville, KY |
| 31 | Sat Mar 7 | atMiami | 2:00 PM | 7-2 | .778 | #6 | ESPN | Watsco Center · Coral Gables, FL |
