| 1 | Mon Nov 3 | vs SC State | 9:00 PM | 20-13 | .606 | #11 | ACC Network | KFC Yum! Center · Louisville, KY |
| 2 | Thu Nov 6 | vsJackson St | 7:00 PM | 16-18 | .471 | #11 | ACC Extra | KFC Yum! Center · Louisville, KY |
| 3 | Tue Nov 11 | vs#9Kentucky | 8:00 PM | 24-12 | .667 | #11 | ESPN | KFC Yum! Center · Louisville, KY |
| 4 | Sat Nov 15 | vsOhio | TBD | 16-16 | .500 | #11 | | KFC Yum! Center · Louisville, KY |
| 5 | Fri Nov 21 | atCincinnati | 6:30 PM | 19-16 | .543 | #11 | | Fifth Third Arena · Cincinnati, OH |
| 6 | Mon Nov 24 | vsE Michigan | 7:00 PM | 16-16 | .500 | #11 | ACC Network | KFC Yum! Center · Louisville, KY |
| 7 | Wed Nov 26 | vsNJIT | 9:00 PM | 6-25 | .194 | #11 | ACC Network | KFC Yum! Center · Louisville, KY |
| 8 | Wed Dec 3 | at#14Arkansas | 7:00 PM | 22-14 | .611 | #11 | ESPN | Bud Walton Arena · Fayetteville, AR |
| 9 | Sat Dec 6 | atIndiana | 2:00 PM | 19-13 | .594 | #11 | | Simon Skjodt Assembly Hall · Bloomington, IN |
| 10 | Sat Dec 13 | vsMemphis | 3:30 PM | 29-6 | .829 | #11 | ESPN | KFC Yum! Center · Louisville, KY |
| 11 | Tue Dec 16 | at#18Tennessee | 7:00 PM | 30-8 | .789 | #11 | ESPN | Thompson-Boling Arena · Knoxville, TN |
| 12 | Sat Dec 20 | vsMontana | 12:00 PM | 25-10 | .714 | #11 | ACC Network | KFC Yum! Center · Louisville, KY |
| 13 | Tue Dec 30 | atCalifornia | 9:00 PM | 14-19 | .424 | #11 | ACC Network | Haas Pavilion · Berkeley, CA |
| 14 | Fri Jan 2 | atStanford | 8:00 PM | 21-14 | .600 | #11 | ACC Network | Maples Pavilion · Stanford, CA |
| 15 | Tue Jan 6 | vs#6Duke | 7:00 PM | 35-4 | .897 | #11 | ESPN | KFC Yum! Center · Louisville, KY |
| 16 | Sat Jan 10 | vsBoston College | TBD | 12-19 | .387 | #11 | | KFC Yum! Center · Louisville, KY |
| 17 | Tue Jan 13 | vsVirginia | TBD | 15-17 | .469 | #11 | | KFC Yum! Center · Louisville, KY |
| 18 | Sat Jan 17 | atPitt | TBD | 17-15 | .531 | #11 | | Petersen Events Center · Pittsburgh, PA |
| 19 | Sat Jan 24 | vsVirginia Tech | TBD | 13-19 | .406 | #11 | | KFC Yum! Center · Louisville, KY |
| 20 | Mon Jan 26 | at#6Duke | 7:00 PM | 35-4 | .897 | #11 | ESPN | Cameron Indoor Stadium · Durham, NC |
| 21 | Sat Jan 31 | vsSMU | TBD | 24-11 | .686 | #11 | | KFC Yum! Center · Louisville, KY |
| 22 | Wed Feb 4 | vsNotre Dame | 7:00 PM | 15-18 | .455 | #11 | ESPN2 | KFC Yum! Center · Louisville, KY |
| 23 | Sat Feb 7 | atWake Forest | 12:00 PM | 21-11 | .656 | #11 | ACC Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 24 | Mon Feb 9 | vsNC State | 7:00 PM | 12-19 | .387 | #11 | ESPN | KFC Yum! Center · Louisville, KY |
| 25 | Sat Feb 14 | atBaylor | 4:00 PM | 20-15 | .571 | #11 | ESPN | Ferrell Center · Waco, TX |
| 26 | Tue Feb 17 | atSMU | TBD | 24-11 | .686 | #11 | | Moody Coliseum · Dallas, TX |
| 27 | Sat Feb 21 | vsGeorgia Tech | TBD | 17-17 | .500 | #11 | | KFC Yum! Center · Louisville, KY |
| 28 | Mon Feb 23 | at#25UNC | 7:00 PM | 23-14 | .622 | #11 | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 29 | Sat Feb 28 | atClemson | TBD | 27-7 | .794 | #11 | | Littlejohn Coliseum · Clemson, SC |
| 30 | Tue Mar 3 | vsSyracuse | 9:00 PM | 14-19 | .424 | #11 | ACC Network | KFC Yum! Center · Louisville, KY |
| 31 | Sat Mar 7 | atMiami | 2:00 PM | 7-24 | .226 | #11 | | Watsco Center · Coral Gables, FL |
