| 1 | Mon Nov 4 | vs TBD | W137-55 | 1-0 | 1.000 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 2 | Fri Nov 8 | at South Carolina | L64-86 | 1-1 | .500 | - | ESPN+ | Colonial Life Arena · Columbia, SC |
| 3 | Mon Nov 11 | vsTBD | W94-48 | 2-1 | .667 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 4 | Thu Nov 14 | at Jacksonville | L62-71 | 2-2 | .500 | - | ESPN+ | Swisher Gymnasium · Jacksonville, FL |
| 5 | Sat Nov 16 | at Bethune | L62-75 | 2-3 | .400 | - | | Moore Gymnasium (FL) · Daytona Beach, FL |
| 6 | Fri Nov 22 | at Alabama A&M | W82-70 | 3-3 | .500 | - | | T.M. Elmore Gymnasium · Normal, AL |
| 7 | Sat Nov 23 | at IU Indy | W72-62 | 4-3 | .571 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 8 | Wed Nov 27 | at Marshall | L53-82 | 4-4 | .500 | - | ESPN+ | Cam Henderson Center · Huntington, WV |
| 9 | Sun Dec 1 | at #22Xavier | L68-71 | 4-5 | .444 | - | FS1 | Cintas Center · Cincinnati, OH |
| 10 | Thu Dec 5 | vs Samford | L81-88 | 4-6 | .400 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 11 | Mon Dec 9 | vs Charleston So | W82-63 | 5-6 | .455 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 12 | Sat Dec 14 | at Furman | L64-68 | 5-7 | .417 | - | ESPN+ | Timmons Arena · Greenville, SC |
| 13 | Wed Dec 18 | at SC Upstate | W85-70 | 6-7 | .462 | - | ESPN+ | G.B. Hodge Center · Spartanburg, SC |
| 14 | Sat Dec 21 | at N Kentucky | L47-58 | 6-8 | .429 | - | ESPN+ | Truist Arena · Highland Heights, KY |
| 15 | Sun Dec 29 | at Georgia | L72-79 | 6-9 | .400 | - | ESPN+ | Stegeman Coliseum · Athens, GA |
| 16 | Sat Jan 4 | at Morgan St | W86-72 | 7-9 | .438 | - | ESPN+ | Hill Field House · Baltimore, MD |
| 17 | Mon Jan 6 | at Coppin St | W85-77 | 8-9 | .471 | - | ESPN+ | Physical Education Complex · Baltimore, MD |
| 18 | Sat Jan 11 | vs Delaware St | L75-76 | 8-10 | .444 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 19 | Mon Jan 13 | vs MD-Eastern | W78-64 | 9-10 | .474 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 20 | Sat Jan 25 | at NC Central | L77-82 | 9-11 | .450 | - | ESPN+ | McDougald-McLendon Arena · Durham, NC |
| 21 | Sat Feb 1 | at Norfolk St | L65-67 (OT) | 9-12 | .429 | - | ESPN+ | Joseph G. Echols Hall · Norfolk, VA |
| 22 | Mon Feb 3 | at Howard | W89-66 | 10-12 | .455 | - | ESPN+ | Burr Gymnasium · Washington, D.C. |
| 23 | Sat Feb 8 | vsTBD | W114-75 | 11-12 | .478 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 24 | Sat Feb 15 | vsMorgan St | W90-62 | 12-12 | .500 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 25 | Mon Feb 17 | vsCoppin St | W87-57 | 13-12 | .520 | - | | S-H-M Memorial Center · Orangeburg, SC |
