| 1 | Wed Nov 25 | vs Appalachian St | L61-81 | 0-1 | .000 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 2 | Sat Nov 28 | at Bowling Green | L78-101 | 0-2 | .000 | - | | Stroh Center · Bowling Green, OH |
| 3 | Wed Dec 2 | at Clemson | L38-75 | 0-3 | .000 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 4 | Sat Dec 5 | at UNC Asheville | L56-77 | 0-4 | .000 | - | | Kimmel Arena · Asheville, NC |
| 5 | Mon Dec 7 | at Charlotte | L40-78 | 0-5 | .000 | - | | Dale F. Halton Arena · Charlotte, NC |
| 6 | Fri Dec 11 | at Charleston | L63-90 | 0-6 | .000 | - | | TD Arena · Charleston, SC |
| 7 | Sun Dec 13 | vs Jacksonville | L58-60 | 0-7 | .000 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 8 | Tue Dec 15 | at Liberty | L52-82 | 0-8 | .000 | - | | Liberty Arena · Lynchburg, VA |
| 9 | Fri Dec 18 | at Presbyterian | L56-62 | 0-9 | .000 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 10 | Mon Dec 21 | at Furman | L52-118 | 0-10 | .000 | - | | Timmons Arena · Greenville, SC |
| 12 | Sat Jan 2 | vs NC A&T | L86-97 | 0-11 | .000 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 13 | Sun Jan 3 | vsNC A&T | L66-73 | 0-12 | .000 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 14 | Sun Jan 10 | at FAMU | L68-70 | 0-13 | .000 | - | | Al Lawson Center · Tallahassee, FL |
| 15 | Mon Jan 11 | atFAMU | PPD | 1-17 | .056 | - | | Al Lawson Center · Tallahassee, FL |
| 16 | Sat Jan 16 | at NC Central | PPD | 1-17 | .056 | - | | McDougald-McLendon Arena · Durham, NC |
| 17 | Sun Jan 17 | atNC Central | PPD | 1-17 | .056 | - | | McDougald-McLendon Arena · Durham, NC |
| 18 | Mon Feb 1 | atNC Central | L77-91 | 0-14 | .000 | - | ESPN2 | McDougald-McLendon Arena · Durham, NC |
| 19 | Tue Feb 2 | atNC Central | L63-64 | 0-15 | .000 | - | | McDougald-McLendon Arena · Durham, NC |
| 20 | Sat Feb 6 | atNC A&T | PPD | 1-17 | .056 | - | | Corbett Sports Center · Greensboro, NC |
| 21 | Sun Feb 7 | atNC A&T | PPD | 1-17 | .056 | - | | Corbett Sports Center · Greensboro, NC |
| 24 | Thu Feb 25 | vsFAMU | L67-75 | 0-16 | .000 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 25 | Sat Feb 27 | vsFAMU | W63-57 | 1-16 | .059 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 26 | Sun Feb 28 | vsFAMU | L58-63 | 1-17 | .056 | - | | S-H-M Memorial Center · Orangeburg, SC |
South Carolina