| 1 | Mon Nov 3 | vs Navy | L55-76 | 0-1 | .000 | - | ESPN+ | Ross E. Templeton P.E. Center · Clinton, SC |
| 2 | Wed Nov 5 | vsTBD | W105-76 | 1-1 | .500 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 3 | Sat Nov 8 | vsETSU | W68-64 | 2-1 | .667 | - | ESPN+ | Ross E. Templeton P.E. Center · Clinton, SC |
| 4 | Mon Nov 10 | atGeorgia St | W63-61 | 3-1 | .750 | - | ESPN+ | GSU Convocation Center · Atlanta, GA |
| 5 | Wed Nov 12 | atSouth Carolina | L61-81 | 3-2 | .600 | - | SECN+ | Colonial Life Arena · Columbia, SC |
| 6 | Sun Nov 16 | atSacramento St | L62-64 | 3-3 | .500 | - | ESPN+ | The Nest · Sacramento, CA |
| 7 | Tue Nov 18 | atCalifornia | L57-67 | 3-4 | .429 | - | ACC Extra | Haas Pavilion · Berkeley, CA |
| 8 | Fri Nov 21 | at19UCLA | L46-86 | 3-5 | .375 | - | BTN | Pauley Pavilion · Los Angeles, CA |
| 9 | Wed Nov 26 | vsTBD | W93-50 | 4-5 | .444 | - | ESPN+ | Ross E. Templeton P.E. Center · Clinton, SC |
| 10 | Sun Nov 30 | atThe Citadel | W69-41 | 5-5 | .500 | - | ESPN+ | McAlister Field House · Charleston, SC |
| 11 | Wed Dec 3 | atWofford | L56-63 | 5-6 | .455 | - | ESPN+ | Jerry Richardson Indoor Stadium · Spartanburg, SC |
| 12 | Sat Dec 6 | vsMorehead St | W80-72 | 6-6 | .500 | - | ESPN+ | Ross E. Templeton P.E. Center · Clinton, SC |
| 13 | Wed Dec 17 | atE Carolina | L53-74 | 6-7 | .462 | - | ESPN+ | Williams Arena at Minges Coliseum · Greenville, NC |
| 14 | Sun Dec 21 | atManhattan | L81-87 | 6-8 | .429 | - | ESPN+ | Draddy Gymnasium · Riverdale, NY |
| 15 | Sun Dec 28 | vsTBD | W91-64 | 7-8 | .467 | - | ESPN+ | Ross E. Templeton P.E. Center · Clinton, SC |
| 16 | Sat Jan 3 | vsSC Upstate | W86-77 | 8-8 | .500 | - | ESPN+ | Ross E. Templeton P.E. Center · Clinton, SC |
| 17 | Wed Jan 7 | atRadford | L61-80 | 8-9 | .471 | - | ESPN+ | Donald N. Dedmon Center · Radford, VA |
| 18 | Sat Jan 10 | atLongwood | L70-77 | 8-10 | .444 | - | ESPN+ | Willett Hall · Farmville, VA |
| 19 | Wed Jan 14 | vsUNC Asheville | W71-70 | 9-10 | .474 | - | ESPN+ | Ross E. Templeton P.E. Center · Clinton, SC |
| 20 | Sat Jan 17 | atGardner-Webb | W92-55 | 10-10 | .500 | - | ESPN+ | Paul Porter Arena · Boiling Springs, NC |
| 21 | Wed Jan 21 | vsCharleston So | W87-83 | 11-10 | .524 | - | ESPN+ | Ross E. Templeton P.E. Center · Clinton, SC |
| 22 | Sat Jan 24 | vsWinthrop | L72-82 | 11-11 | .500 | - | ESPN+ | Ross E. Templeton P.E. Center · Clinton, SC |
| 23 | Thu Jan 29 | atHigh Point | L81-84 | 11-12 | .478 | - | ESPNU | Nido and Mariana Qubein Arena · High Point, NC |
| 24 | Sat Jan 31 | vsRadford | L84-93 (2OT) | 11-13 | .458 | - | ESPN+ | Ross E. Templeton P.E. Center · Clinton, SC |
| 25 | Sat Feb 7 | vsGardner-Webb | W68-62 | 12-13 | .480 | - | ESPN+ | Ross E. Templeton P.E. Center · Clinton, SC |
| 26 | Thu Feb 12 | atCharleston So | L67-84 | 12-14 | .462 | - | ESPN+ | Buccaneer Fieldhouse · Charleston, SC |
| 27 | Sat Feb 14 | atUNC Asheville | W58-57 | 13-14 | .481 | - | ESPN+ | Kimmel Arena · Asheville, NC |
| 28 | Thu Feb 19 | vsLongwood | W72-65 | 14-14 | .500 | - | ESPN+ | Ross E. Templeton P.E. Center · Clinton, SC |
| 29 | Sat Feb 21 | atSC Upstate | L74-76 | 14-15 | .483 | - | ESPN+ | G.B. Hodge Center · Spartanburg, SC |
| 30 | Thu Feb 26 | vsHigh Point | L73-79 | 14-16 | .467 | - | ESPNU | Ross E. Templeton P.E. Center · Clinton, SC |
| 31 | Sat Feb 28 | atWinthrop | L70-74 | 14-17 | .452 | - | ESPN+ | Winthrop Coliseum · Rock Hill, SC |
