| 1 | Mon Nov 4 | at Charlotte | L79-88 | 0-1 | .000 | - | ESPN+ | Dale F. Halton Arena · Charlotte, NC |
| 2 | Wed Nov 6 | vsTBD | W120-45 | 1-1 | .500 | - | ESPN+ | Ross E. Templeton P.E. Center · Clinton, SC |
| 3 | Fri Nov 8 | atNC State | L72-81 | 1-2 | .333 | - | ESPN+ | PNC Arena · Raleigh, NC |
| 4 | Wed Nov 13 | vsWofford | W71-68 | 2-2 | .500 | - | ESPN+ | Ross E. Templeton P.E. Center · Clinton, SC |
| 5 | Sat Nov 16 | atKennesaw St | L67-85 | 2-3 | .400 | - | ESPN+ | KSU Convocation Center · Kennesaw, GA |
| 6 | Thu Nov 21 | atSF Austin | W58-55 (OT) | 3-3 | .500 | - | ESPN+ | William R. Johnson Coliseum · Nacogdoches, TX |
| 7 | Fri Nov 22 | atYoungstown St | W67-42 | 4-3 | .571 | - | | William R. Johnson Coliseum · Nacogdoches, TX |
| 8 | Sat Nov 23 | atMonmouth | W71-61 | 5-3 | .625 | - | | William R. Johnson Coliseum · Nacogdoches, TX |
| 9 | Wed Nov 27 | atTennessee Tech | L75-90 | 5-4 | .556 | - | ESPN+ | Hooper Eblen Center · Cookeville, TN |
| 10 | Tue Dec 3 | atFAMU | L63-66 | 5-5 | .500 | - | | Al Lawson Center · Tallahassee, FL |
| 11 | Wed Dec 11 | vsTBD | W97-57 | 6-5 | .545 | - | ESPN+ | Ross E. Templeton P.E. Center · Clinton, SC |
| 12 | Sun Dec 15 | atMiami | L75-94 | 6-6 | .500 | - | ESPN+ | Watsco Center · Coral Gables, FL |
| 13 | Wed Dec 18 | vsTBD | W116-53 | 7-6 | .538 | - | ESPN+ | Ross E. Templeton P.E. Center · Clinton, SC |
| 14 | Sat Dec 21 | vsManhattan | L81-86 (OT) | 7-7 | .500 | - | ESPN+ | Ross E. Templeton P.E. Center · Clinton, SC |
| 15 | Mon Dec 30 | atSouth Carolina | L59-69 | 7-8 | .467 | - | SEC Network | Colonial Life Arena · Columbia, SC |
| 16 | Thu Jan 2 | vsLongwood | W68-60 | 8-8 | .500 | - | ESPN+ | Ross E. Templeton P.E. Center · Clinton, SC |
| 17 | Sat Jan 4 | atGardner-Webb | L61-63 | 8-9 | .471 | - | ESPN+ | Paul Porter Arena · Boiling Springs, NC |
| 18 | Wed Jan 8 | atSC Upstate | L67-77 | 8-10 | .444 | - | ESPN+ | G.B. Hodge Center · Spartanburg, SC |
| 19 | Sat Jan 11 | vsUNC Asheville | L87-96 | 8-11 | .421 | - | ESPN+ | Ross E. Templeton P.E. Center · Clinton, SC |
| 20 | Sat Jan 18 | atHigh Point | L66-77 | 8-12 | .400 | - | ESPN+ | Nido and Mariana Qubein Arena · High Point, NC |
| 21 | Wed Jan 22 | vsCharleston So | W71-61 | 9-12 | .429 | - | ESPN+ | Ross E. Templeton P.E. Center · Clinton, SC |
| 22 | Sat Jan 25 | vsRadford | L69-82 | 9-13 | .409 | - | ESPN+ | Ross E. Templeton P.E. Center · Clinton, SC |
| 23 | Wed Jan 29 | atWinthrop | L67-76 | 9-14 | .391 | - | ESPN+ | Winthrop Coliseum · Rock Hill, SC |
| 24 | Sat Feb 1 | vsHigh Point | L72-84 | 9-15 | .375 | - | ESPN+ | Ross E. Templeton P.E. Center · Clinton, SC |
| 25 | Wed Feb 5 | vsSC Upstate | W75-64 | 10-15 | .400 | - | ESPN+ | Ross E. Templeton P.E. Center · Clinton, SC |
| 26 | Wed Feb 12 | atCharleston So | L70-71 | 10-16 | .385 | - | ESPN+ | Buccaneer Fieldhouse · Charleston, SC |
| 27 | Sat Feb 15 | atLongwood | W77-68 | 11-16 | .407 | - | ESPN+ | Willett Hall · Farmville, VA |
| 28 | Wed Feb 19 | vsWinthrop | L77-81 | 11-17 | .393 | - | ESPN+ | Ross E. Templeton P.E. Center · Clinton, SC |
| 29 | Sat Feb 22 | atRadford | W80-73 | 12-17 | .414 | - | ESPN+ | Donald N. Dedmon Center · Radford, VA |
| 30 | Wed Feb 26 | atUNC Asheville | W64-59 | 13-17 | .433 | - | ESPN+ | Kimmel Arena · Asheville, NC |
| 31 | Sat Mar 1 | vsGardner-Webb | W68-57 | 14-17 | .452 | - | ESPN+ | Ross E. Templeton P.E. Center · Clinton, SC |
| 32 | Fri Mar 7 | atRadford | L69-74 (OT) | 14-18 | .438 | - | ESPN+ | Freedom Hall Civic Center · Johnson City, TN |
| 33 | Sun Mar 23 | vsIllinois St | L70-78 | 14-19 | .424 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
