| 1 | Thu Nov 7 | at Clemson | L45-79 | 0-1 | .000 | - | ACC Network | Littlejohn Coliseum · Clemson, SC |
| 2 | Mon Nov 11 | atVMI | W80-77 (OT) | 1-1 | .500 | - | | Cameron Hall · Lexington, VA |
| 3 | Thu Nov 14 | vsMorehead St | L55-77 | 1-2 | .333 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 4 | Mon Nov 18 | atNotre Dame | L53-63 | 1-3 | .250 | - | | Purcell Pavilion · South Bend, IN |
| 5 | Fri Nov 22 | vsSacred Heart | L57-83 | 1-4 | .200 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 6 | Sat Nov 23 | atQuinnipiac | L64-73 | 1-5 | .167 | - | | M&T Bank Arena · Hamden, CT |
| 7 | Sun Nov 24 | atAlbany | L60-65 | 1-6 | .143 | - | | SEFCU Arena · Albany, NY |
| 8 | Sat Nov 30 | vsTBD | W87-59 | 2-6 | .250 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 9 | Sat Dec 7 | atSC State | L68-80 | 2-7 | .222 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 10 | Tue Dec 10 | atSt Francis BK | L63-64 | 2-8 | .200 | - | | Pope Physical Education Center · Brooklyn, NY |
| 11 | Wed Dec 18 | vsJacksonville | L58-81 | 2-9 | .182 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 12 | Sat Dec 21 | at#14Michigan | L44-86 | 2-10 | .167 | - | BTN | Crisler Center · Ann Arbor, MI |
| 13 | Sun Dec 29 | vsTBD | W81-56 | 3-10 | .231 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 14 | Thu Jan 2 | vsUNC Asheville | W79-77 | 4-10 | .286 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 15 | Sat Jan 4 | atGardner-Webb | W68-62 | 5-10 | .333 | - | | Paul Porter Arena · Boiling Springs, NC |
| 16 | Sat Jan 11 | vsHigh Point | W77-62 | 6-10 | .375 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 17 | Thu Jan 16 | atLongwood | W74-67 | 7-10 | .412 | - | | Willett Hall · Farmville, VA |
| 18 | Sat Jan 18 | vsRadford | L64-75 | 7-11 | .389 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 19 | Mon Jan 20 | vsCampbell | W85-79 | 8-11 | .421 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 20 | Thu Jan 23 | atCharleston So | L66-74 | 8-12 | .400 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 21 | Sat Jan 25 | atWinthrop | L57-72 | 8-13 | .381 | - | | Winthrop Coliseum · Rock Hill, SC |
| 22 | Thu Jan 30 | vsSC Upstate | L74-77 | 8-14 | .364 | - | ESPNU | Ross E. Templeton P.E. Center · Clinton, SC |
| 23 | Sat Feb 1 | atHampton | L81-87 (OT) | 8-15 | .348 | - | | Convocation Center (VA) · Hampton, VA |
| 24 | Thu Feb 6 | vsGardner-Webb | W65-61 | 9-15 | .375 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 25 | Sat Feb 8 | atCampbell | L62-79 | 9-16 | .360 | - | | John W. Pope Jr. Convocation Center · Buies Creek, NC |
| 26 | Thu Feb 13 | atRadford | L71-81 | 9-17 | .346 | - | | Donald N. Dedmon Center · Radford, VA |
| 27 | Sat Feb 15 | vsWinthrop | L88-89 | 9-18 | .333 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 28 | Thu Feb 20 | atHigh Point | L70-82 | 9-19 | .321 | - | | Nido and Mariana Qubein Arena · High Point, NC |
| 29 | Sat Feb 22 | atUNC Asheville | L64-75 | 9-20 | .310 | - | | Kimmel Arena · Asheville, NC |
| 30 | Thu Feb 27 | vsLongwood | L55-58 | 9-21 | .300 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 31 | Sat Feb 29 | vsCharleston So | W76-65 | 10-21 | .323 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 32 | Tue Mar 3 | atCharleston So | L64-81 | 10-22 | .313 | - | | Buccaneer Fieldhouse · Charleston, SC |
