| 1 | Mon Nov 3 | at CA Baptist | 10:30 PM | 17-15 | .531 | - | ESPN+ | CBU Events Center · Riverside, CA |
| 2 | Wed Nov 5 | atFresno St | 9:00 PM | 6-26 | .188 | - | | Save Mart Center · Fresno, CA |
| 3 | Sat Nov 8 | vsTBD | 12:00 PM | 0-0 | .000 | - | ESPN+ | G.B. Hodge Center · Spartanburg, SC |
| 4 | Wed Nov 12 | vsTBD | 7:00 PM | 0-0 | .000 | - | ESPN+ | G.B. Hodge Center · Spartanburg, SC |
| 5 | Sat Nov 15 | atUNC Wilmington | TBD | 27-8 | .771 | - | | Trask Coliseum · Wilmington, NC |
| 6 | Wed Nov 19 | vsTennessee Tech | TBD | 15-17 | .469 | - | ESPN+ | G.B. Hodge Center · Spartanburg, SC |
| 7 | Fri Nov 21 | atW Georgia | TBD | 6-25 | .194 | - | ESPN+ | The Coliseum · Carrollton, GA |
| 8 | Tue Nov 25 | vsNC Central | 7:00 PM | 14-19 | .424 | - | ESPN+ | G.B. Hodge Center · Spartanburg, SC |
| 9 | Sat Nov 29 | atNebraska | 8:30 PM | 21-14 | .600 | - | B1G+ | Pinnacle Bank Arena · Lincoln, NE |
| 10 | Wed Dec 3 | vsCoast Car | 7:00 PM | 10-22 | .313 | - | | G.B. Hodge Center · Spartanburg, SC |
| 11 | Sat Dec 6 | vsW Carolina | 2:00 PM | 8-22 | .267 | - | | G.B. Hodge Center · Spartanburg, SC |
| 12 | Sat Dec 13 | at#25UNC | TBD | 23-14 | .622 | - | | Dean E. Smith Center · Chapel Hill, NC |
| 13 | Tue Dec 16 | atSC State | 1:00 PM | 20-13 | .606 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 14 | Wed Dec 17 | vsTBD | 7:00 PM | 0-0 | .000 | - | | G.B. Hodge Center · Spartanburg, SC |
| 15 | Sat Dec 20 | atYoungstown St | 1:00 PM | 21-13 | .618 | - | | Beeghly Center · Youngstown, OH |
| 16 | Wed Dec 31 | vsRadford | 7:00 PM | 20-13 | .606 | - | | G.B. Hodge Center · Spartanburg, SC |
| 17 | Sat Jan 3 | atPresbyterian | TBD | 14-19 | .424 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 18 | Sat Jan 10 | vsWinthrop | 2:00 PM | 23-11 | .676 | - | | G.B. Hodge Center · Spartanburg, SC |
| 19 | Wed Jan 14 | atCharleston So | 7:00 PM | 10-22 | .313 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 20 | Sat Jan 17 | atHigh Point | 7:00 PM | 29-6 | .829 | - | | Nido and Mariana Qubein Arena · High Point, NC |
| 21 | Wed Jan 21 | vsUNC Asheville | 7:00 PM | 21-11 | .656 | - | | G.B. Hodge Center · Spartanburg, SC |
| 22 | Sat Jan 24 | atGardner-Webb | 2:00 PM | 11-20 | .355 | - | | Paul Porter Arena · Boiling Springs, NC |
| 23 | Thu Jan 29 | vsLongwood | 7:00 PM | 18-14 | .563 | - | | G.B. Hodge Center · Spartanburg, SC |
| 24 | Wed Feb 4 | atUNC Asheville | TBD | 21-11 | .656 | - | | Kimmel Arena · Asheville, NC |
| 25 | Sat Feb 7 | vsCharleston So | 2:00 PM | 10-22 | .313 | - | | G.B. Hodge Center · Spartanburg, SC |
| 26 | Thu Feb 12 | vsHigh Point | 7:00 PM | 29-6 | .829 | - | | G.B. Hodge Center · Spartanburg, SC |
| 27 | Sat Feb 14 | atLongwood | TBD | 18-14 | .563 | - | | Willett Hall · Farmville, VA |
| 28 | Thu Feb 19 | atWinthrop | TBD | 23-11 | .676 | - | | Winthrop Coliseum · Rock Hill, SC |
| 29 | Sat Feb 21 | vsPresbyterian | 4:30 PM | 14-19 | .424 | - | | G.B. Hodge Center · Spartanburg, SC |
| 30 | Thu Feb 26 | atRadford | TBD | 20-13 | .606 | - | | Donald N. Dedmon Center · Radford, VA |
| 31 | Sat Feb 28 | vsGardner-Webb | 2:00 PM | 11-20 | .355 | - | | G.B. Hodge Center · Spartanburg, SC |
