| 1 | Tue Nov 9 | at South Carolina | L60-78 | 0-1 | .000 | - | | Colonial Life Arena · Columbia, SC |
| 2 | Fri Nov 12 | atCharlotte | L64-76 | 0-2 | .000 | - | | Dale F. Halton Arena · Charlotte, NC |
| 3 | Mon Nov 15 | vsTBD | W96-43 | 1-2 | .333 | - | | G.B. Hodge Center · Spartanburg, SC |
| 4 | Thu Nov 18 | atETSU | L43-56 | 1-3 | .250 | - | | Freedom Hall Civic Center · Johnson City, TN |
| 5 | Tue Nov 23 | atSC State | W82-78 | 2-3 | .400 | - | | S-H-M Memorial Center · Orangeburg, SC |
| 6 | Sat Nov 27 | vsFurman | L77-87 | 2-4 | .333 | - | | G.B. Hodge Center · Spartanburg, SC |
| 7 | Wed Dec 1 | vsNC Central | L65-67 | 2-5 | .286 | - | | G.B. Hodge Center · Spartanburg, SC |
| 8 | Sat Dec 4 | vsW Carolina | L73-78 | 2-6 | .250 | - | | G.B. Hodge Center · Spartanburg, SC |
| 9 | Sat Dec 11 | atWake Forest | L53-79 | 2-7 | .222 | - | | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 10 | Tue Dec 14 | at#18Tennessee | L52-96 | 2-8 | .200 | - | | Thompson-Boling Arena · Knoxville, TN |
| 11 | Sat Dec 18 | vsTBD | W78-38 | 3-8 | .273 | - | | G.B. Hodge Center · Spartanburg, SC |
| 12 | Tue Dec 21 | atOhio | L70-85 | 3-9 | .250 | - | | Convocation Center (OH) · Athens, OH |
| 14 | Thu Jan 6 | vsRadford | L77-82 | 3-10 | .231 | - | | G.B. Hodge Center · Spartanburg, SC |
| 15 | Sat Jan 8 | atPresbyterian | W82-72 | 4-10 | .286 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 16 | Wed Jan 12 | vsHigh Point | W66-65 | 5-10 | .333 | - | | G.B. Hodge Center · Spartanburg, SC |
| 17 | Sat Jan 15 | atUNC Asheville | W76-73 | 6-10 | .375 | - | | Kimmel Arena · Asheville, NC |
| 18 | Wed Jan 19 | atGardner-Webb | W74-61 | 7-10 | .412 | - | | Paul Porter Arena · Boiling Springs, NC |
| 19 | Sat Jan 22 | vsCharleston So | W70-57 | 8-10 | .444 | - | | G.B. Hodge Center · Spartanburg, SC |
| 20 | Wed Jan 26 | vsWinthrop | L91-95 (OT) | 8-11 | .421 | - | | G.B. Hodge Center · Spartanburg, SC |
| 21 | Sat Jan 29 | atNC A&T | W84-64 | 9-11 | .450 | - | | Corbett Sports Center · Greensboro, NC |
| 22 | Wed Feb 2 | atHampton | W85-78 | 10-11 | .476 | - | | Convocation Center (VA) · Hampton, VA |
| 23 | Sat Feb 5 | vsCampbell | L71-80 | 10-12 | .455 | - | | G.B. Hodge Center · Spartanburg, SC |
| 24 | Thu Feb 10 | atLongwood | L72-85 | 10-13 | .435 | - | ESPNU | Willett Hall · Farmville, VA |
| 25 | Sat Feb 12 | vsUNC Asheville | L56-83 | 10-14 | .417 | - | | G.B. Hodge Center · Spartanburg, SC |
| 26 | Wed Feb 16 | vsPresbyterian | W60-55 | 11-14 | .440 | - | | G.B. Hodge Center · Spartanburg, SC |
| 27 | Sat Feb 19 | atCharleston So | W78-73 (OT) | 12-14 | .462 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 28 | Thu Feb 24 | atWinthrop | L59-89 | 12-15 | .444 | - | ESPNU | Winthrop Coliseum · Rock Hill, SC |
| 29 | Sat Feb 26 | vsGardner-Webb | W72-70 | 13-15 | .464 | - | | G.B. Hodge Center · Spartanburg, SC |
| 30 | Fri Mar 4 | vsCharleston So | W72-62 | 14-15 | .483 | - | | G.B. Hodge Center · Spartanburg, SC |
| 31 | Sat Mar 5 | atLongwood | L70-79 | 14-16 | .467 | - | | Willett Hall · Farmville, VA |
| 32 | Tue Mar 15 | atAppalachian St | W80-74 | 15-16 | .484 | - | | Holmes Convocation Center · Boone, NC |
| 33 | Mon Mar 21 | atSouth Alabama | L79-83 | 15-17 | .469 | - | | Mitchell Center · Mobile, AL |
