| 1 | Mon Nov 4 | at NC State | L66-97 | 0-1 | .000 | - | ESPN+ | PNC Arena · Raleigh, NC |
| 2 | Wed Nov 6 | vs TBD | W103-70 | 1-1 | .500 | - | ESPN+ | G.B. Hodge Center · Spartanburg, SC |
| 3 | Fri Nov 8 | at Virginia Tech | L74-93 | 1-2 | .333 | - | ESPN+ | Cassell Coliseum · Blacksburg, VA |
| 4 | Wed Nov 13 | at Wake Forest | L80-85 | 1-3 | .250 | - | ESPN+ | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 5 | Fri Nov 15 | vs UNC Wilmington | L85-89 | 1-4 | .200 | - | ESPN+ | G.B. Hodge Center · Spartanburg, SC |
| 6 | Tue Nov 19 | vsTBD | W95-63 | 2-4 | .333 | - | ESPN+ | G.B. Hodge Center · Spartanburg, SC |
| 7 | Fri Nov 22 | at ETSU | L76-87 | 2-5 | .286 | - | ESPN+ | Freedom Hall Civic Center · Johnson City, TN |
| 8 | Sat Nov 23 | at Queens | L74-98 | 2-6 | .250 | - | | Curry Arena · Charlotte, NC |
| 9 | Tue Nov 26 | at Iowa | L77-110 | 2-7 | .222 | - | BTN | Carver-Hawkeye Arena · Iowa City, IA |
| 10 | Sat Nov 30 | at Coast Car | L51-73 | 2-8 | .200 | - | ESPN+ | The HTC Center · Conway, SC |
| 11 | Wed Dec 4 | vsTBD | W91-60 | 3-8 | .273 | - | ESPN+ | G.B. Hodge Center · Spartanburg, SC |
| 12 | Sat Dec 7 | at W Carolina | W74-68 | 4-8 | .333 | - | ESPN+ | Ramsey Regional Activity Center · Cullowhee, NC |
| 13 | Sat Dec 14 | at South Carolina | L53-73 | 4-9 | .308 | - | ESPN+ | Colonial Life Arena · Columbia, SC |
| 14 | Wed Dec 18 | vs SC State | L70-85 | 4-10 | .286 | - | ESPN+ | G.B. Hodge Center · Spartanburg, SC |
| 15 | Sat Dec 21 | vs Youngstown St | L64-72 | 4-11 | .267 | - | ESPN+ | G.B. Hodge Center · Spartanburg, SC |
| 16 | Thu Jan 2 | at Winthrop | L76-95 | 4-12 | .250 | - | ESPN+ | Winthrop Coliseum · Rock Hill, SC |
| 17 | Wed Jan 8 | vs Presbyterian | W77-67 | 5-12 | .294 | - | ESPN+ | G.B. Hodge Center · Spartanburg, SC |
| 18 | Sat Jan 11 | vs Radford | L67-80 | 5-13 | .278 | - | ESPN+ | G.B. Hodge Center · Spartanburg, SC |
| 19 | Wed Jan 15 | at UNC Asheville | L92-93 | 5-14 | .263 | - | ESPN+ | Kimmel Arena · Asheville, NC |
| 20 | Sat Jan 18 | at Gardner-Webb | L68-97 | 5-15 | .250 | - | ESPN+ | Paul Porter Arena · Boiling Springs, NC |
| 21 | Wed Jan 22 | vs High Point | L77-86 | 5-16 | .238 | - | ESPN+ | G.B. Hodge Center · Spartanburg, SC |
| 22 | Sat Jan 25 | at Longwood | L54-80 | 5-17 | .227 | - | ESPN+ | Willett Hall · Farmville, VA |
| 23 | Wed Jan 29 | vs Charleston So | L75-82 | 5-18 | .217 | - | ESPN+ | G.B. Hodge Center · Spartanburg, SC |
| 24 | Sat Feb 1 | atRadford | L69-79 | 5-19 | .208 | - | ESPN+ | Donald N. Dedmon Center · Radford, VA |
| 25 | Wed Feb 5 | atPresbyterian | L64-75 | 5-20 | .200 | - | ESPN+ | Ross E. Templeton P.E. Center · Clinton, SC |
| 26 | Sat Feb 8 | vsWinthrop | L95-105 | 5-21 | .192 | - | ESPN+ | G.B. Hodge Center · Spartanburg, SC |
| 27 | Wed Feb 12 | vsUNC Asheville | L85-92 | 5-22 | .185 | - | ESPN+ | G.B. Hodge Center · Spartanburg, SC |
| 28 | Sat Feb 15 | vsGardner-Webb | L87-96 | 5-23 | .179 | - | ESPN+ | G.B. Hodge Center · Spartanburg, SC |
