| 1 | Mon Nov 3 | at Pitt | L59-74 | 0-1 | .000 | - | ACC Extra | Petersen Events Center · Pittsburgh, PA |
| 2 | Fri Nov 7 | atGrand Canyon | W90-81 | 1-1 | .500 | - | | GCU Arena · Phoenix, AZ |
| 3 | Mon Nov 10 | vsTBD | W115-53 | 2-1 | .667 | - | ESPN+ | Beeghly Center · Youngstown, OH |
| 4 | Sat Nov 15 | atSt Bonaventure | L80-84 | 2-2 | .500 | - | ESPN+ | Reilly Center · Saint Bonaventure, NY |
| 5 | Wed Nov 19 | atToledo | L75-92 | 2-3 | .400 | - | ESPN+ | Savage Arena · Toledo, OH |
| 6 | Sun Nov 23 | atUNC Greensboro | L62-68 | 2-4 | .333 | - | | Greensboro Coliseum · Greensboro, NC |
| 7 | Mon Nov 24 | vsGeorgia So | W67-61 | 3-4 | .429 | - | | Beeghly Center · Youngstown, OH |
| 8 | Fri Nov 28 | vsChicago St | W87-64 | 4-4 | .500 | - | ESPN+ | Beeghly Center · Youngstown, OH |
| 9 | Wed Dec 3 | vsWright St | W69-68 | 5-4 | .556 | - | ESPN+ | Beeghly Center · Youngstown, OH |
| 10 | Sat Dec 6 | atIU Indy | W78-55 | 6-4 | .600 | - | ESPN+ | Indiana Farmers Coliseum · Indianapolis, IN |
| 11 | Sun Dec 14 | vsTBD | W103-52 | 7-4 | .636 | - | ESPN+ | Beeghly Center · Youngstown, OH |
| 12 | Wed Dec 17 | atRobert Morris | L77-80 (OT) | 7-5 | .583 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 13 | Sat Dec 20 | vsSC Upstate | W74-65 | 8-5 | .615 | - | ESPN+ | Beeghly Center · Youngstown, OH |
| 14 | Mon Dec 29 | vsDetroit Mercy | L68-73 | 8-6 | .571 | - | ESPN+ | Beeghly Center · Youngstown, OH |
| 15 | Thu Jan 1 | vsOakland | L83-85 | 8-7 | .533 | - | ESPN+ | Beeghly Center · Youngstown, OH |
| 16 | Sun Jan 4 | atN Kentucky | L79-94 | 8-8 | .500 | - | ESPN+ | Truist Arena · Highland Heights, KY |
| 17 | Wed Jan 7 | vsPurdue FW | L69-71 | 8-9 | .471 | - | ESPN+ | Beeghly Center · Youngstown, OH |
| 18 | Fri Jan 9 | vsTBD | W99-61 | 9-9 | .500 | - | ESPN+ | Beeghly Center · Youngstown, OH |
| 19 | Thu Jan 15 | atWright St | L83-93 | 9-10 | .474 | - | ESPN+ | Nutter Center · Dayton, OH |
| 20 | Sat Jan 17 | atCleveland St | L78-80 | 9-11 | .450 | - | ESPN+ | Wolstein Center · Cleveland, OH |
| 21 | Thu Jan 22 | vsGreen Bay | W88-81 | 10-11 | .476 | - | ESPN+ | Beeghly Center · Youngstown, OH |
| 22 | Sat Jan 24 | vsMilwaukee | L64-65 | 10-12 | .455 | - | ESPN+ | Beeghly Center · Youngstown, OH |
| 23 | Fri Jan 30 | vsIU Indy | W85-76 | 11-12 | .478 | - | ESPN+ | Beeghly Center · Youngstown, OH |
| 24 | Wed Feb 4 | atPurdue FW | W90-61 | 12-12 | .500 | - | ESPN+ | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 25 | Sat Feb 7 | vsRobert Morris | L66-72 | 12-13 | .480 | - | ESPN+ | Beeghly Center · Youngstown, OH |
| 26 | Thu Feb 12 | atOakland | W86-82 | 13-13 | .500 | - | ESPN+ | Athletics Center O'rena · Rochester, MI |
| 27 | Sun Feb 15 | atDetroit Mercy | L70-76 | 13-14 | .481 | - | ESPN+ | Calihan Hall · Detroit, MI |
| 28 | Wed Feb 18 | vsCleveland St | W106-82 | 14-14 | .500 | - | ESPN+ | Beeghly Center · Youngstown, OH |
| 29 | Sun Feb 22 | vsN Kentucky | W64-58 | 15-14 | .517 | - | ESPN+ | Beeghly Center · Youngstown, OH |
| 30 | Wed Feb 25 | atMilwaukee | L65-78 | 15-15 | .500 | - | ESPN+ | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 31 | Sat Feb 28 | atGreen Bay | L63-85 | 15-16 | .484 | - | ESPN+ | Resch Center · Ashwaubenon, WI |
