| 2 | Sat Nov 9 | at Chicago St | W80-60 | 1-0 | 1.000 | - | | Jones Convocation Center · Chicago, IL |
| 3 | Mon Nov 11 | at21Ohio State | L47-81 | 1-1 | .500 | - | BTN | Value City Arena · Columbus, OH |
| 4 | Sat Nov 16 | atSyracuse | L95-104 (2OT) | 1-2 | .333 | - | ESPN+ | JMA Wireless Dome · Syracuse, NY |
| 5 | Thu Nov 21 | atMonmouth | W72-62 | 2-2 | .500 | - | | William R. Johnson Coliseum · Nacogdoches, TX |
| 6 | Fri Nov 22 | vsPresbyterian | L42-67 | 2-3 | .400 | - | | William R. Johnson Coliseum · Nacogdoches, TX |
| 7 | Sat Nov 23 | atSF Austin | L57-64 | 2-4 | .333 | - | | William R. Johnson Coliseum · Nacogdoches, TX |
| 8 | Wed Nov 27 | vsW Michigan | L62-73 | 2-5 | .286 | - | ESPN+ | Beeghly Center · Youngstown, OH |
| 9 | Sat Nov 30 | vsTBD | W128-60 | 3-5 | .375 | - | ESPN+ | Beeghly Center · Youngstown, OH |
| 10 | Wed Dec 4 | atRobert Morris | W72-58 | 4-5 | .444 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 11 | Sat Dec 7 | vsOakland | W66-50 | 5-5 | .500 | - | ESPN+ | Beeghly Center · Youngstown, OH |
| 12 | Sat Dec 14 | vsToledo | W93-87 | 6-5 | .545 | - | ESPN+ | Beeghly Center · Youngstown, OH |
| 13 | Wed Dec 18 | atWright St | W80-70 | 7-5 | .583 | - | ESPN+ | Nutter Center · Dayton, OH |
| 14 | Sat Dec 21 | atSC Upstate | W72-64 | 8-5 | .615 | - | ESPN+ | G.B. Hodge Center · Spartanburg, SC |
| 15 | Sun Dec 29 | vsDetroit Mercy | W73-64 | 9-5 | .643 | - | ESPN+ | Beeghly Center · Youngstown, OH |
| 16 | Wed Jan 1 | atIU Indy | W77-61 | 10-5 | .667 | - | ESPN+ | Indiana Farmers Coliseum · Indianapolis, IN |
| 17 | Sat Jan 4 | atPurdue FW | L81-90 | 10-6 | .625 | - | ESPN+ | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 18 | Wed Jan 8 | vsN Kentucky | W72-61 | 11-6 | .647 | - | ESPN+ | Beeghly Center · Youngstown, OH |
| 19 | Sat Jan 11 | vsCleveland St | L72-80 | 11-7 | .611 | - | ESPN+ | Beeghly Center · Youngstown, OH |
| 20 | Fri Jan 17 | atMilwaukee | L64-79 | 11-8 | .579 | - | ESPN+ | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 21 | Sun Jan 19 | atGreen Bay | W73-69 | 12-8 | .600 | - | ESPN+ | Resch Center · Ashwaubenon, WI |
| 22 | Wed Jan 22 | vsRobert Morris | L70-72 | 12-9 | .571 | - | ESPN+ | Beeghly Center · Youngstown, OH |
| 23 | Fri Jan 24 | vsTBD | W112-63 | 13-9 | .591 | - | ESPN+ | Beeghly Center · Youngstown, OH |
| 24 | Thu Jan 30 | vsWright St | W88-86 | 14-9 | .609 | - | ESPN+ | Beeghly Center · Youngstown, OH |
| 25 | Sat Feb 1 | vsIU Indy | L79-84 | 14-10 | .583 | - | ESPN+ | Beeghly Center · Youngstown, OH |
| 26 | Thu Feb 6 | atOakland | W84-75 | 15-10 | .600 | - | ESPN+ | Athletics Center O'rena · Rochester, MI |
| 27 | Sat Feb 8 | atDetroit Mercy | W87-72 | 16-10 | .615 | - | ESPN+ | Calihan Hall · Detroit, MI |
| 28 | Wed Feb 12 | vsPurdue FW | W93-71 | 17-10 | .630 | - | ESPN+ | Beeghly Center · Youngstown, OH |
| 29 | Sun Feb 16 | atCleveland St | W68-60 | 18-10 | .643 | - | ESPNU | Wolstein Center · Cleveland, OH |
| 30 | Fri Feb 21 | vsMilwaukee | L74-84 | 18-11 | .621 | - | ESPNU | Beeghly Center · Youngstown, OH |
| 31 | Sun Feb 23 | vsGreen Bay | W81-77 | 19-11 | .633 | - | ESPN+ | Beeghly Center · Youngstown, OH |
| 32 | Sat Mar 1 | atN Kentucky | L79-88 | 19-12 | .613 | - | ESPN+ | Truist Arena · Highland Heights, KY |
| 33 | Thu Mar 6 | vsPurdue FW | W72-67 | 20-12 | .625 | - | ESPN+ | Beeghly Center · Youngstown, OH |
| 34 | Mon Mar 10 | atCleveland St | W56-54 | 21-12 | .636 | - | ESPN2 | Indiana Farmers Coliseum · Indianapolis, IN |
| 35 | Tue Mar 11 | atRobert Morris | L78-89 | 21-13 | .618 | - | ESPN | Indiana Farmers Coliseum · Indianapolis, IN |
