| 1 | Mon Nov 6 | at Louisiana | L62-72 | 0-1 | .000 | - | | Cajundome · Lafayette, LA |
| 2 | Fri Nov 10 | at Michigan | L62-92 | 0-2 | .000 | - | BTN | Crisler Center · Ann Arbor, MI |
| 3 | Mon Nov 13 | vs TBD | W99-71 | 1-2 | .333 | - | | Beeghly Center · Youngstown, OH |
| 4 | Fri Nov 17 | vs Utah Tech | W75-68 | 2-2 | .500 | - | | Beeghly Center · Youngstown, OH |
| 5 | Sun Nov 19 | vsTBD | W79-57 | 3-2 | .600 | - | | Beeghly Center · Youngstown, OH |
| 6 | Fri Nov 24 | at Dayton | L69-77 | 3-3 | .500 | - | | UD Arena · Dayton, OH |
| 7 | Wed Nov 29 | vs Cleveland St | W94-69 | 4-3 | .571 | - | | Beeghly Center · Youngstown, OH |
| 8 | Sat Dec 2 | at Robert Morris | W71-57 | 5-3 | .625 | - | | UPMC Events Center · Moon Township, PA |
| 9 | Wed Dec 6 | at Ohio | W78-72 | 6-3 | .667 | - | | Convocation Center (OH) · Athens, OH |
| 10 | Sat Dec 9 | at W Michigan | W72-68 | 7-3 | .700 | - | | University Arena (MI) · Kalamazoo, MI |
| 11 | Thu Dec 14 | vsTBD | W107-70 | 8-3 | .727 | - | | Beeghly Center · Youngstown, OH |
| 12 | Mon Dec 18 | vsTBD | W117-45 | 9-3 | .750 | - | | Beeghly Center · Youngstown, OH |
| 13 | Thu Dec 21 | vs Navy | W75-65 | 10-3 | .769 | - | | Beeghly Center · Youngstown, OH |
| 14 | Sun Dec 31 | vs Oakland | L81-88 | 10-4 | .714 | - | | Beeghly Center · Youngstown, OH |
| 15 | Thu Jan 4 | at N Kentucky | L76-79 | 10-5 | .667 | - | | Truist Arena · Highland Heights, KY |
| 16 | Sun Jan 7 | vs IU Indy | W75-65 | 11-5 | .688 | - | | Beeghly Center · Youngstown, OH |
| 17 | Wed Jan 10 | vs Purdue FW | W93-85 | 12-5 | .706 | - | | Beeghly Center · Youngstown, OH |
| 18 | Fri Jan 12 | vs Wright St | W81-71 | 13-5 | .722 | - | ESPN2 | Beeghly Center · Youngstown, OH |
| 19 | Wed Jan 17 | atOakland | L67-70 | 13-6 | .684 | - | | Athletics Center O'rena · Rochester, MI |
| 20 | Sat Jan 20 | at Detroit Mercy | W105-64 | 14-6 | .700 | - | | Calihan Hall · Detroit, MI |
| 21 | Thu Jan 25 | atIU Indy | W78-50 | 15-6 | .714 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 22 | Sun Jan 28 | vsN Kentucky | W82-52 | 16-6 | .727 | - | | Beeghly Center · Youngstown, OH |
| 23 | Thu Feb 1 | atWright St | W88-77 | 17-6 | .739 | - | ESPNU | Nutter Center · Dayton, OH |
| 24 | Sun Feb 4 | atPurdue FW | L78-82 | 17-7 | .708 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 25 | Thu Feb 8 | vs Milwaukee | W97-85 (OT) | 18-7 | .720 | - | | Beeghly Center · Youngstown, OH |
| 26 | Sat Feb 10 | vs Green Bay | L83-84 | 18-8 | .692 | - | | Beeghly Center · Youngstown, OH |
| 27 | Wed Feb 14 | vsRobert Morris | W87-77 | 19-8 | .704 | - | | Beeghly Center · Youngstown, OH |
| 28 | Sat Feb 17 | atCleveland St | L73-81 | 19-9 | .679 | - | | Wolstein Center · Cleveland, OH |
| 29 | Fri Feb 23 | atMilwaukee | W84-80 (OT) | 20-9 | .690 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 30 | Sun Feb 25 | atGreen Bay | W71-59 | 21-9 | .700 | - | | Resch Center · Ashwaubenon, WI |
| 31 | Wed Feb 28 | vsDetroit Mercy | W69-55 | 22-9 | .710 | - | | Beeghly Center · Youngstown, OH |
| 32 | Thu Mar 7 | vsCleveland St | L70-82 | 22-10 | .688 | - | | Beeghly Center · Youngstown, OH |
