| 1 | Mon Nov 7 | at Canisius | W92-81 | 1-0 | 1.000 | - | | Koessler Athletic Center · Buffalo, NY |
| 2 | Wed Nov 9 | vsUT Martin | W90-72 | 2-0 | 1.000 | - | | Beeghly Center · Youngstown, OH |
| 3 | Sun Nov 13 | atNotre Dame | L81-88 | 2-1 | .667 | - | | Purcell Pavilion · South Bend, IN |
| 4 | Tue Nov 15 | vsTBD | W96-68 | 3-1 | .750 | - | | Beeghly Center · Youngstown, OH |
| 5 | Sat Nov 19 | atUC San Diego | W73-54 | 4-1 | .800 | - | | Alumni Hall (Navy) · Annapolis, MD |
| 6 | Sun Nov 20 | atNavy | L67-80 | 4-2 | .667 | - | | Alumni Hall (Navy) · Annapolis, MD |
| 7 | Sat Nov 26 | atW Illinois | W88-64 | 5-2 | .714 | - | | LeRoy A. Ufkes Court at Western Hall · Macomb, IL |
| 8 | Thu Dec 1 | atN Kentucky | L73-77 (2OT) | 5-3 | .625 | - | | Truist Arena · Highland Heights, KY |
| 9 | Sun Dec 4 | atWright St | W88-77 | 6-3 | .667 | - | | Nutter Center · Dayton, OH |
| 10 | Thu Dec 8 | vsTBD | W117-65 | 7-3 | .700 | - | | Beeghly Center · Youngstown, OH |
| 11 | Sun Dec 11 | vsOhio | L79-81 | 7-4 | .636 | - | | Beeghly Center · Youngstown, OH |
| 12 | Fri Dec 16 | vsSouthern | W85-81 | 8-4 | .667 | - | | Beeghly Center · Youngstown, OH |
| 13 | Wed Dec 21 | atC Michigan | W76-65 | 9-4 | .692 | - | | McGuirk Arena · Mount Pleasant, MI |
| 14 | Thu Dec 29 | vsCleveland St | W85-71 | 10-4 | .714 | - | | Beeghly Center · Youngstown, OH |
| 15 | Sat Dec 31 | vsPurdue FW | L71-76 | 10-5 | .667 | - | | Beeghly Center · Youngstown, OH |
| 16 | Thu Jan 5 | vsRobert Morris | W78-56 | 11-5 | .688 | - | | Beeghly Center · Youngstown, OH |
| 17 | Sat Jan 7 | vsIU Indy | W105-74 | 12-5 | .706 | - | | Beeghly Center · Youngstown, OH |
| 18 | Thu Jan 12 | atDetroit Mercy | W84-79 | 13-5 | .722 | - | | Calihan Hall · Detroit, MI |
| 19 | Sat Jan 14 | atOakland | W85-69 | 14-5 | .737 | - | | Athletics Center O'rena · Rochester, MI |
| 20 | Thu Jan 19 | atGreen Bay | W86-70 | 15-5 | .750 | - | | Resch Center · Ashwaubenon, WI |
| 21 | Sat Jan 21 | atMilwaukee | L75-88 | 15-6 | .714 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 22 | Fri Jan 27 | vsOakland | W77-73 | 16-6 | .727 | - | ESPN2 | Beeghly Center · Youngstown, OH |
| 23 | Sun Jan 29 | vsDetroit Mercy | W73-63 | 17-6 | .739 | - | | Beeghly Center · Youngstown, OH |
| 24 | Thu Feb 2 | vsWright St | W91-89 (3OT) | 18-6 | .750 | - | | Beeghly Center · Youngstown, OH |
| 25 | Sat Feb 4 | vsN Kentucky | W74-56 | 19-6 | .760 | - | | Beeghly Center · Youngstown, OH |
| 26 | Fri Feb 10 | atPurdue FW | W81-72 | 20-6 | .769 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 27 | Sun Feb 12 | atCleveland St | L78-81 | 20-7 | .741 | - | | Wolstein Center · Cleveland, OH |
| 28 | Thu Feb 16 | vsMilwaukee | W87-58 | 21-7 | .750 | - | | Beeghly Center · Youngstown, OH |
| 29 | Sat Feb 18 | vsGreen Bay | W95-65 | 22-7 | .759 | - | | Beeghly Center · Youngstown, OH |
| 30 | Tue Feb 21 | atRobert Morris | L64-83 | 22-8 | .733 | - | | UPMC Events Center · Moon Township, PA |
| 31 | Sat Feb 25 | atIU Indy | W93-79 | 23-8 | .742 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 32 | Thu Mar 2 | vsDetroit Mercy | W71-66 | 24-8 | .750 | - | | Beeghly Center · Youngstown, OH |
| 33 | Mon Mar 6 | vsN Kentucky | L63-75 | 24-9 | .727 | - | ESPNU | Indiana Farmers Coliseum · Indianapolis, IN |
| 34 | Wed Mar 15 | vsOklahoma St | L64-69 | 24-10 | .706 | - | | Beeghly Center · Youngstown, OH |
