| Thu Nov 7 | at Loyola Chicago | 12:00 AM | 23-10 | .697 | Joseph J. Gentile Arena · Chicago, IL |
| Sat Nov 16 | vs Toledo | 4:00 PM | 20-12 | .625 | Calihan Hall · Detroit, MI |
| Wed Nov 20 | at Ball State | 12:00 AM | 15-16 | .484 | Worthen Arena · Muncie, IN |
| Sat Nov 23 | at Wake Forest | 12:00 AM | 21-14 | .600 | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| Sat Nov 30 | at E Michigan | 7:00 PM | 13-18 | .419 | Convocation Center (MI) · Ypsilanti, MI |
| Thu Dec 5 | vs Purdue FW | 12:00 AM | 23-13 | .639 | Calihan Hall · Detroit, MI |
| Sat Dec 7 | vs Wright St | 12:00 AM | 18-14 | .563 | Calihan Hall · Detroit, MI |
| Wed Dec 18 | at N Kentucky | 12:00 AM | 18-15 | .545 | Truist Arena · Highland Heights, KY |
| Sun Dec 22 | at Wisconsin | 12:00 AM | 22-14 | .611 | Kohl Center · Madison, WI |
| Sun Dec 29 | at Youngstown St | 12:00 AM | 22-10 | .688 | Beeghly Center · Youngstown, OH |
| Thu Jan 2 | vs Robert Morris | 12:00 AM | 10-22 | .313 | Calihan Hall · Detroit, MI |
| Sat Jan 4 | vs Milwaukee | 12:00 AM | 20-15 | .571 | Calihan Hall · Detroit, MI |
| Thu Jan 9 | at IUPUI | 12:00 AM | 6-26 | .188 | Indiana Farmers Coliseum · Indianapolis, IN |
| Sat Jan 11 | atPurdue FW | 12:00 AM | 23-13 | .639 | Allen County War Memorial Coliseum · Fort Wayne, IN |
| Sat Jan 18 | vs Oakland | 12:00 AM | 24-12 | .667 | Calihan Hall · Detroit, MI |
| Wed Jan 22 | at Cleveland St | 12:00 AM | 21-15 | .583 | Wolstein Center · Cleveland, OH |
| Sat Jan 25 | atWright St | 12:00 AM | 18-14 | .563 | Nutter Center · Dayton, OH |
| Thu Jan 30 | vsN Kentucky | 12:00 AM | 18-15 | .545 | Calihan Hall · Detroit, MI |
| Sat Feb 1 | vs Green Bay | 12:00 AM | 18-14 | .563 | Calihan Hall · Detroit, MI |
| Wed Feb 5 | atRobert Morris | 12:00 AM | 10-22 | .313 | UPMC Events Center · Moon Township, PA |
| Sat Feb 8 | vsYoungstown St | 12:00 AM | 22-10 | .688 | Calihan Hall · Detroit, MI |
| Sun Feb 16 | atOakland | 12:00 AM | 24-12 | .667 | Athletics Center O'rena · Rochester, MI |
| Wed Feb 19 | vsIUPUI | 12:00 AM | 6-26 | .188 | Calihan Hall · Detroit, MI |
| Fri Feb 21 | vsCleveland St | 12:00 AM | 21-15 | .583 | Calihan Hall · Detroit, MI |
| Thu Feb 27 | atGreen Bay | 12:00 AM | 18-14 | .563 | Resch Center · Ashwaubenon, WI |
| Sat Mar 1 | atMilwaukee | 12:00 AM | 20-15 | .571 | UW-Milwaukee Panther Arena · Milwaukee, WI |
