| 1 | Mon Nov 4 | vs TBD | W91-52 | 1-0 | 1.000 | - | ESPN+ | Calihan Hall · Detroit, MI |
| 2 | Thu Nov 7 | at Loyola Chicago | L65-87 | 1-1 | .500 | - | ESPN+ | Joseph J. Gentile Arena · Chicago, IL |
| 3 | Sun Nov 10 | vs Niagara | W84-78 (OT) | 2-1 | .667 | - | ESPN+ | Calihan Hall · Detroit, MI |
| 4 | Sat Nov 16 | vs Toledo | L67-82 | 2-2 | .500 | - | ESPN+ | Calihan Hall · Detroit, MI |
| 5 | Wed Nov 20 | at Ball State | W70-59 | 3-2 | .600 | - | ESPN+ | Worthen Arena · Muncie, IN |
| 6 | Sat Nov 23 | at Wake Forest | L57-67 | 3-3 | .500 | - | ESPN+ | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 7 | Tue Nov 26 | vs Tulsa | L44-63 | 3-4 | .429 | - | | Calihan Hall · Detroit, MI |
| 8 | Wed Nov 27 | vs Rhode Island | L75-81 | 3-5 | .375 | - | | Calihan Hall · Detroit, MI |
| 9 | Sat Nov 30 | at E Michigan | W98-89 (OT) | 4-5 | .444 | - | ESPN+ | Convocation Center (MI) · Ypsilanti, MI |
| 10 | Thu Dec 5 | vs Purdue FW | W79-78 | 5-5 | .500 | - | ESPN+ | Calihan Hall · Detroit, MI |
| 11 | Sat Dec 7 | vs Wright St | L72-80 | 5-6 | .455 | - | ESPN+ | Calihan Hall · Detroit, MI |
| 12 | Sat Dec 14 | at Davidson | L51-86 | 5-7 | .417 | - | ESPN+ | John M. Belk Arena · Davidson, NC |
| 13 | Wed Dec 18 | at N Kentucky | L60-73 | 5-8 | .385 | - | ESPN+ | Truist Arena · Highland Heights, KY |
| 14 | Sun Dec 22 | at Wisconsin | L53-76 | 5-9 | .357 | - | BTN | Kohl Center · Madison, WI |
| 15 | Sun Dec 29 | at Youngstown St | L64-73 | 5-10 | .333 | - | ESPN+ | Beeghly Center · Youngstown, OH |
| 16 | Thu Jan 2 | vs Robert Morris | W78-76 (OT) | 6-10 | .375 | - | ESPN+ | Calihan Hall · Detroit, MI |
| 17 | Sat Jan 4 | vs Milwaukee | L56-64 | 6-11 | .353 | - | ESPN+ | Calihan Hall · Detroit, MI |
| 18 | Thu Jan 9 | at IU Indy | L61-95 | 6-12 | .333 | - | ESPN+ | Indiana Farmers Coliseum · Indianapolis, IN |
| 19 | Sat Jan 11 | atPurdue FW | L67-90 | 6-13 | .316 | - | ESPN+ | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 20 | Sat Jan 18 | vs Oakland | L59-65 | 6-14 | .300 | - | ESPN+ | Calihan Hall · Detroit, MI |
| 21 | Wed Jan 22 | at Cleveland St | L50-65 | 6-15 | .286 | - | ESPN+ | Wolstein Center · Cleveland, OH |
| 22 | Sat Jan 25 | atWright St | L50-67 | 6-16 | .273 | - | ESPN+ | Nutter Center · Dayton, OH |
| 23 | Thu Jan 30 | vsN Kentucky | W68-57 | 7-16 | .304 | - | ESPN+ | Calihan Hall · Detroit, MI |
| 24 | Sat Feb 1 | vs Green Bay | W67-57 | 8-16 | .333 | - | ESPN+ | Calihan Hall · Detroit, MI |
| 25 | Wed Feb 5 | atRobert Morris | L56-71 | 8-17 | .320 | - | ESPN+ | UPMC Events Center · Moon Township, PA |
| 26 | Sat Feb 8 | vsYoungstown St | L72-87 | 8-18 | .308 | - | ESPN+ | Calihan Hall · Detroit, MI |
| 27 | Sun Feb 16 | atOakland | L83-93 (OT) | 8-19 | .296 | - | ESPN+ | Athletics Center O'rena · Rochester, MI |
| 28 | Wed Feb 19 | vsIU Indy | L71-80 | 8-20 | .286 | - | ESPN+ | Calihan Hall · Detroit, MI |
| 29 | Fri Feb 21 | vsCleveland St | L65-73 | 8-21 | .276 | - | ESPN+ | Calihan Hall · Detroit, MI |
| 30 | Thu Feb 27 | atGreen Bay | L71-76 | 8-22 | .267 | - | ESPN+ | Resch Center · Ashwaubenon, WI |
| 31 | Sat Mar 1 | atMilwaukee | L67-89 | 8-23 | .258 | - | ESPN+ | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 32 | Tue Mar 4 | atN Kentucky | L75-99 | 8-24 | .250 | - | ESPN+ | Truist Arena · Highland Heights, KY |
