| 3 | Fri Dec 4 | at #8Michigan St | L76-83 | 0-1 | .000 | - | BTN | Breslin Center · East Lansing, MI |
| 4 | Sun Dec 6 | atNotre Dame | L70-78 | 0-2 | .000 | - | ACC Network | Purcell Pavilion · South Bend, IN |
| 5 | Tue Dec 8 | vsKent State | L66-80 | 0-3 | .000 | - | | Calihan Hall · Detroit, MI |
| 6 | Sat Dec 12 | atW Michigan | W67-57 | 1-3 | .250 | - | | University Arena (MI) · Kalamazoo, MI |
| 8 | Sat Dec 19 | vsWright St | L70-93 | 1-4 | .200 | - | | Calihan Hall · Detroit, MI |
| 9 | Sun Dec 20 | vsWright St | L72-85 | 1-5 | .167 | - | | Calihan Hall · Detroit, MI |
| 10 | Sat Dec 26 | vsOakland | L75-77 (OT) | 1-6 | .143 | - | | Calihan Hall · Detroit, MI |
| 11 | Sun Dec 27 | vsOakland | L80-83 | 1-7 | .125 | - | | Calihan Hall · Detroit, MI |
| 14 | Fri Jan 15 | vsGreen Bay | W86-61 | 2-7 | .222 | - | | Calihan Hall · Detroit, MI |
| 15 | Sat Jan 16 | vsGreen Bay | W68-65 | 3-7 | .300 | - | | Calihan Hall · Detroit, MI |
| 16 | Fri Jan 22 | atOakland | L81-86 | 3-8 | .273 | - | | Athletics Center O'rena · Rochester, MI |
| 17 | Sat Jan 23 | atOakland | W82-72 | 4-8 | .333 | - | | Athletics Center O'rena · Rochester, MI |
| 18 | Fri Jan 29 | atYoungstown St | W78-75 | 5-8 | .385 | - | | Beeghly Center · Youngstown, OH |
| 19 | Sat Jan 30 | atYoungstown St | W77-72 | 6-8 | .429 | - | | Beeghly Center · Youngstown, OH |
| 20 | Fri Feb 5 | vsPurdue FW | W82-72 | 7-8 | .467 | - | | Calihan Hall · Detroit, MI |
| 21 | Sat Feb 6 | vsPurdue FW | W83-56 | 8-8 | .500 | - | | Calihan Hall · Detroit, MI |
| 22 | Fri Feb 12 | atCleveland St | W89-83 | 9-8 | .529 | - | ESPNU | Wolstein Center · Cleveland, OH |
| 23 | Sat Feb 13 | atCleveland St | L64-71 | 9-9 | .500 | - | | Wolstein Center · Cleveland, OH |
| 24 | Fri Feb 19 | vsRobert Morris | W85-74 | 10-9 | .526 | - | | Calihan Hall · Detroit, MI |
| 25 | Sat Feb 20 | vsRobert Morris | W80-61 | 11-9 | .550 | - | | Calihan Hall · Detroit, MI |
| 26 | Thu Feb 25 | vsRobert Morris | W83-73 | 12-9 | .571 | - | | Calihan Hall · Detroit, MI |
| 27 | Tue Mar 2 | atN Kentucky | L69-70 | 12-10 | .545 | - | | Truist Arena · Highland Heights, KY |
