| 1 | Tue Nov 8 | vs TBD | W93-65 | 1-0 | 1.000 | - | | Calihan Hall · Detroit, MI |
| 2 | Fri Nov 11 | atBoston College | L66-70 | 1-1 | .500 | - | | Silvio O. Conte Forum · Chestnut Hill, MA |
| 3 | Wed Nov 16 | vsOhio | W88-74 | 2-1 | .667 | - | | Calihan Hall · Detroit, MI |
| 4 | Sat Nov 19 | atFAU | L55-76 | 2-2 | .500 | - | | FAU Arena · Boca Raton, FL |
| 5 | Mon Nov 21 | vsBryant | L88-98 | 2-3 | .400 | - | | FAU Arena · Boca Raton, FL |
| 6 | Wed Nov 23 | vsCharlotte | W70-49 | 3-3 | .500 | - | | Calihan Hall · Detroit, MI |
| 7 | Fri Nov 25 | atWashington St | L54-96 | 3-4 | .429 | - | PACN | Friel Court at Beasley Coliseum · Pullman, WA |
| 8 | Thu Dec 1 | atPurdue FW | W75-66 | 4-4 | .500 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 9 | Sat Dec 3 | atCleveland St | L77-92 | 4-5 | .444 | - | | Wolstein Center · Cleveland, OH |
| 10 | Wed Dec 7 | atTulsa | W76-72 | 5-5 | .500 | - | | Donald W. Reynolds Center · Tulsa, OK |
| 11 | Sat Dec 10 | atCharlotte | L80-82 (OT) | 5-6 | .455 | - | | Dale F. Halton Arena · Charlotte, NC |
| 12 | Sun Dec 18 | atE Michigan | L77-79 | 5-7 | .417 | - | | Convocation Center (MI) · Ypsilanti, MI |
| 13 | Wed Dec 21 | atCincinnati | L54-72 | 5-8 | .385 | - | | Fifth Third Arena · Cincinnati, OH |
| 14 | Thu Dec 29 | vsGreen Bay | W76-59 | 6-8 | .429 | - | | Calihan Hall · Detroit, MI |
| 15 | Sat Dec 31 | vsMilwaukee | L81-84 | 6-9 | .400 | - | | Calihan Hall · Detroit, MI |
| 16 | Fri Jan 6 | atWright St | L85-90 | 6-10 | .375 | - | ESPN2 | Nutter Center · Dayton, OH |
| 17 | Sun Jan 8 | atN Kentucky | L76-78 (OT) | 6-11 | .353 | - | | Truist Arena · Highland Heights, KY |
| 18 | Thu Jan 12 | vsYoungstown St | L79-84 | 6-12 | .333 | - | | Calihan Hall · Detroit, MI |
| 19 | Sat Jan 14 | vsRobert Morris | W87-75 | 7-12 | .368 | - | | Calihan Hall · Detroit, MI |
| 20 | Sat Jan 21 | atIU Indy | W89-77 | 8-12 | .400 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 21 | Mon Jan 23 | vsOakland | L67-76 | 8-13 | .381 | - | | Calihan Hall · Detroit, MI |
| 22 | Fri Jan 27 | atRobert Morris | L77-85 | 8-14 | .364 | - | | UPMC Events Center · Moon Township, PA |
| 23 | Sun Jan 29 | atYoungstown St | L63-73 | 8-15 | .348 | - | | Beeghly Center · Youngstown, OH |
| 24 | Thu Feb 2 | vsCleveland St | W85-67 | 9-15 | .375 | - | | Calihan Hall · Detroit, MI |
| 25 | Sat Feb 4 | vsPurdue FW | W85-52 | 10-15 | .400 | - | | Calihan Hall · Detroit, MI |
| 26 | Thu Feb 9 | atMilwaukee | L89-94 | 10-16 | .385 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 27 | Sat Feb 11 | atGreen Bay | W76-71 | 11-16 | .407 | - | | Resch Center · Ashwaubenon, WI |
| 28 | Fri Feb 17 | atOakland | W96-74 | 12-16 | .429 | - | | Athletics Center O'rena · Rochester, MI |
| 29 | Sun Feb 19 | vsIU Indy | W81-68 | 13-16 | .448 | - | | Calihan Hall · Detroit, MI |
| 30 | Thu Feb 23 | vsN Kentucky | L64-67 | 13-17 | .433 | - | | Calihan Hall · Detroit, MI |
| 31 | Sat Feb 25 | vsWright St | L71-82 | 13-18 | .419 | - | | Calihan Hall · Detroit, MI |
| 32 | Tue Feb 28 | vsPurdue FW | W81-68 | 14-18 | .438 | - | | Calihan Hall · Detroit, MI |
| 33 | Thu Mar 2 | atYoungstown St | L66-71 | 14-19 | .424 | - | | Beeghly Center · Youngstown, OH |
