| 1 | Mon Nov 6 | at Toledo | L60-94 | 0-1 | .000 | - | | Savage Arena · Toledo, OH |
| 2 | Fri Nov 10 | at Cincinnati | L61-93 | 0-2 | .000 | - | | Fifth Third Arena · Cincinnati, OH |
| 3 | Tue Nov 14 | at Ole Miss | L69-70 | 0-3 | .000 | - | | SJB Pavilion · Oxford, MS |
| 4 | Sat Nov 18 | at Ohio | L52-71 | 0-4 | .000 | - | | Convocation Center (OH) · Athens, OH |
| 5 | Tue Nov 21 | vs E Michigan | L72-76 | 0-5 | .000 | - | | Calihan Hall · Detroit, MI |
| 6 | Sat Nov 25 | at SIUE | L67-81 | 0-6 | .000 | - | | First Community Arena at the Vadalabene Center · Edwardsville, IL |
| 7 | Wed Nov 29 | vs Oakland | L50-65 | 0-7 | .000 | - | | Calihan Hall · Detroit, MI |
| 8 | Sat Dec 2 | at Cleveland St | L58-69 | 0-8 | .000 | - | | Wolstein Center · Cleveland, OH |
| 9 | Wed Dec 6 | vs Ball State | L65-68 | 0-9 | .000 | - | | Calihan Hall · Detroit, MI |
| 10 | Sun Dec 10 | at Northwestern | L59-91 | 0-10 | .000 | - | | Welsh-Ryan Arena · Evanston, IL |
| 11 | Mon Dec 18 | at LMU | L56-76 | 0-11 | .000 | - | | Gersten Pavilion · Los Angeles, CA |
| 12 | Thu Dec 21 | at C Michigan | L63-75 | 0-12 | .000 | - | | McGuirk Arena · Mount Pleasant, MI |
| 13 | Sat Dec 23 | at NC State | L66-83 | 0-13 | .000 | - | ACC Network | PNC Arena · Raleigh, NC |
| 14 | Fri Dec 29 | at IU Indy | L55-67 | 0-14 | .000 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 15 | Sun Dec 31 | at Purdue FW | L56-91 | 0-15 | .000 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 16 | Thu Jan 4 | vs Green Bay | L51-69 | 0-16 | .000 | - | | Calihan Hall · Detroit, MI |
| 17 | Sat Jan 6 | vs Milwaukee | L61-84 | 0-17 | .000 | - | | Calihan Hall · Detroit, MI |
| 18 | Sat Jan 13 | vs N Kentucky | L76-81 | 0-18 | .000 | - | | Calihan Hall · Detroit, MI |
| 19 | Wed Jan 17 | at Robert Morris | L99-102 (2OT) | 0-19 | .000 | - | | UPMC Events Center · Moon Township, PA |
| 20 | Sat Jan 20 | vs Youngstown St | L64-105 | 0-20 | .000 | - | | Calihan Hall · Detroit, MI |
| 21 | Thu Jan 25 | atMilwaukee | L71-87 | 0-21 | .000 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 22 | Sat Jan 27 | atGreen Bay | L64-78 | 0-22 | .000 | - | | Resch Center · Ashwaubenon, WI |
| 23 | Thu Feb 1 | vsCleveland St | L65-77 | 0-23 | .000 | - | | Calihan Hall · Detroit, MI |
| 24 | Sat Feb 3 | vsRobert Morris | L67-75 | 0-24 | .000 | - | | Calihan Hall · Detroit, MI |
| 25 | Thu Feb 8 | at Wright St | L85-92 | 0-25 | .000 | - | | Nutter Center · Dayton, OH |
| 26 | Sat Feb 10 | atN Kentucky | L67-79 | 0-26 | .000 | - | | Truist Arena · Highland Heights, KY |
| 27 | Wed Feb 14 | vsIU Indy | W81-66 | 1-26 | .037 | - | | Calihan Hall · Detroit, MI |
| 28 | Sat Feb 17 | vsPurdue FW | L69-83 | 1-27 | .036 | - | | Calihan Hall · Detroit, MI |
| 29 | Thu Feb 22 | vsWright St | L78-93 | 1-28 | .034 | - | | Calihan Hall · Detroit, MI |
| 30 | Wed Feb 28 | atYoungstown St | L55-69 | 1-29 | .033 | - | | Beeghly Center · Youngstown, OH |
| 31 | Sat Mar 2 | atOakland | L70-75 | 1-30 | .032 | - | | Athletics Center O'rena · Rochester, MI |
| 32 | Tue Mar 5 | atMilwaukee | L79-83 | 1-31 | .031 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
