| 1 | Wed Nov 10 | at Wyoming | L47-85 | 0-1 | .000 | - | | Arena Auditorium · Laramie, WY |
| 2 | Sat Nov 13 | at Toledo | L73-81 | 0-2 | .000 | - | | Savage Arena · Toledo, OH |
| 3 | Wed Nov 17 | at Mississippi St | L64-77 | 0-3 | .000 | - | | Humphrey Coliseum · Starkville, MS |
| 4 | Sat Nov 20 | at Louisville | L67-73 | 0-4 | .000 | - | | KFC Yum! Center · Louisville, KY |
| 5 | Sat Nov 27 | at Hofstra | L84-98 | 0-5 | .000 | - | | David S. Mack Sports and Exhibition Complex · Hempstead, NY |
| 6 | Tue Nov 30 | at Northeastern | L56-66 | 0-6 | .000 | - | | Matthews Arena · Boston, MA |
| 7 | Thu Dec 2 | at IU Indy | W69-45 | 1-6 | .143 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 8 | Sun Dec 5 | at UIC | W64-56 | 2-6 | .250 | - | | Credit Union 1 Arena · Chicago, IL |
| 9 | Thu Dec 9 | at Kent State | L52-69 | 2-7 | .222 | - | | M.A.C. Center · Kent, OH |
| 10 | Sat Dec 11 | vs W Michigan | W83-64 | 3-7 | .300 | - | | Calihan Hall · Detroit, MI |
| 11 | Sun Dec 19 | vs C Michigan | W89-75 | 4-7 | .364 | - | | Calihan Hall · Detroit, MI |
| 15 | Fri Jan 7 | vs Milwaukee | W85-60 | 5-7 | .417 | - | ESPN2 | Calihan Hall · Detroit, MI |
| 17 | Thu Jan 13 | at Purdue FW | L60-62 | 5-8 | .385 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 18 | Sat Jan 15 | at Cleveland St | L70-72 | 5-9 | .357 | - | | Wolstein Center · Cleveland, OH |
| 19 | Thu Jan 20 | at Green Bay | L63-70 | 5-10 | .333 | - | | Resch Center · Ashwaubenon, WI |
| 20 | Sat Jan 22 | atMilwaukee | W71-58 | 6-10 | .375 | - | | UW-Milwaukee Panther Arena · Milwaukee, WI |
| 21 | Thu Jan 27 | vsUIC | W80-67 | 7-10 | .412 | - | | Calihan Hall · Detroit, MI |
| 23 | Mon Jan 31 | vs TBD | W96-51 | 8-10 | .444 | - | | Calihan Hall · Detroit, MI |
| 24 | Thu Feb 3 | at Wright St | PPD | 14-16 | .467 | - | | Nutter Center · Dayton, OH |
| 25 | Fri Feb 4 | atWright St | L59-90 | 8-11 | .421 | - | | Nutter Center · Dayton, OH |
| 26 | Sat Feb 5 | at N Kentucky | W74-68 | 9-11 | .450 | - | | Truist Arena · Highland Heights, KY |
| 28 | Wed Feb 9 | at Robert Morris | W79-62 | 10-11 | .476 | - | | UPMC Events Center · Moon Township, PA |
| 29 | Fri Feb 11 | at Youngstown St | L69-82 | 10-12 | .455 | - | | Beeghly Center · Youngstown, OH |
| 30 | Sun Feb 13 | at Oakland | L59-75 | 10-13 | .435 | - | | Athletics Center O'rena · Rochester, MI |
| 31 | Fri Feb 18 | vsN Kentucky | W60-52 | 11-13 | .458 | - | | Calihan Hall · Detroit, MI |
| 32 | Sun Feb 20 | vsWright St | W80-75 | 12-13 | .480 | - | | Calihan Hall · Detroit, MI |
| 33 | Thu Feb 24 | vsCleveland St | W74-67 | 13-13 | .500 | - | | Calihan Hall · Detroit, MI |
| 34 | Sat Feb 26 | vsPurdue FW | L78-81 | 13-14 | .481 | - | | Calihan Hall · Detroit, MI |
| 35 | Tue Mar 1 | vsGreen Bay | W79-62 | 14-14 | .500 | - | | Calihan Hall · Detroit, MI |
| 36 | Thu Mar 3 | atN Kentucky | L59-77 | 14-15 | .483 | - | | Truist Arena · Highland Heights, KY |
| 37 | Wed Mar 16 | at FGCU | L79-95 | 14-16 | .467 | - | | Alico Arena · Fort Myers, FL |
