| 1 | Mon Nov 4 | at Boston Univ | W80-72 | 1-0 | 1.000 | - | ESPN+ | Case Gym · Boston, MA |
| 2 | Sun Nov 10 | vs Princeton | L76-79 | 1-1 | .500 | - | FloSports | Matthews Arena · Boston, MA |
| 3 | Wed Nov 13 | vs Harvard | W78-56 | 2-1 | .667 | - | FloSports | Matthews Arena · Boston, MA |
| 4 | Sat Nov 16 | vs C Connecticut | W80-62 | 3-1 | .750 | - | ESPN+ | Matthews Arena · Boston, MA |
| 5 | Fri Nov 22 | at FIU | W60-58 | 4-1 | .800 | - | | Ocean Bank Convocation Center · Miami, FL |
| 6 | Sat Nov 23 | at FGCU | W59-55 | 5-1 | .833 | - | ESPN+ | Alico Arena · Fort Myers, FL |
| 7 | Sun Nov 24 | vs Bakersfield | L60-68 | 5-2 | .714 | - | | Matthews Arena · Boston, MA |
| 8 | Sat Nov 30 | at Vermont | L64-68 | 5-3 | .625 | - | ESPN+ | Patrick Gymnasium · Burlington, VT |
| 9 | Tue Dec 3 | vs La Salle | W82-68 | 6-3 | .667 | - | | Matthews Arena · Boston, MA |
| 10 | Sun Dec 8 | vs Colgate | W78-75 | 7-3 | .700 | - | | Matthews Arena · Boston, MA |
| 11 | Sun Dec 15 | at Old Dominion | W75-71 | 8-3 | .727 | - | ESPN+ | Chartway Arena · Norfolk, VA |
| 12 | Wed Dec 18 | at UMass | L72-77 | 8-4 | .667 | - | ESPN+ | William D. Mullins Memorial Center · Amherst, MA |
| 13 | Sun Dec 29 | at Northwestern | L60-85 | 8-5 | .615 | - | Peacock | Welsh-Ryan Arena · Evanston, IL |
| 14 | Thu Jan 2 | vs Delaware | W80-77 | 9-5 | .643 | - | | Matthews Arena · Boston, MA |
| 15 | Sat Jan 4 | vs Hofstra | L37-55 | 9-6 | .600 | - | | Matthews Arena · Boston, MA |
| 16 | Thu Jan 9 | at Towson | L73-80 | 9-7 | .563 | - | | SECU Arena · Towson, MD |
| 17 | Sat Jan 11 | at Stony Brook | W70-66 | 10-7 | .588 | - | | Island FCU Arena · Stony Brook, NY |
| 18 | Thu Jan 16 | at UNC Wilmington | L72-80 | 10-8 | .556 | - | | Trask Coliseum · Wilmington, NC |
| 19 | Sat Jan 18 | at Charleston | L85-87 | 10-9 | .526 | - | | TD Arena · Charleston, SC |
| 20 | Thu Jan 23 | vs Drexel | W70-61 | 11-9 | .550 | - | | Matthews Arena · Boston, MA |
| 21 | Mon Jan 27 | vsTowson | L65-75 | 11-10 | .524 | - | CBS | Matthews Arena · Boston, MA |
| 22 | Thu Jan 30 | at Hampton | W78-69 | 12-10 | .545 | - | | Convocation Center (VA) · Hampton, VA |
| 23 | Sat Feb 1 | at Elon | L60-71 | 12-11 | .522 | - | | Schar Center · Elon, NC |
| 24 | Thu Feb 6 | atHofstra | W77-68 | 13-11 | .542 | - | | David S. Mack Sports and Exhibition Complex · Hempstead, NY |
| 25 | Sat Feb 8 | vsHampton | L75-84 | 13-12 | .520 | - | | Matthews Arena · Boston, MA |
| 26 | Thu Feb 13 | vs Campbell | W67-58 | 14-12 | .538 | - | | Matthews Arena · Boston, MA |
| 27 | Sat Feb 15 | vsStony Brook | W71-60 | 15-12 | .556 | - | CBS | Matthews Arena · Boston, MA |
| 28 | Thu Feb 20 | vsCharleston | L62-73 | 15-13 | .536 | - | | Matthews Arena · Boston, MA |
