| 1 | Mon Nov 3 | vs Boston Univ | L75-76 (OT) | 0-1 | .000 | - | | Matthews Arena · Boston, MA |
| 2 | Fri Nov 7 | atColgate | W68-65 | 1-1 | .500 | - | ESPN+ | Cotterell Court · Hamilton, NY |
| 3 | Tue Nov 11 | atHarvard | W77-60 | 2-1 | .667 | - | ESPN+ | Lavietes Pavilion · Cambridge, MA |
| 4 | Sat Nov 15 | vsVermont | L74-85 | 2-2 | .500 | - | | Matthews Arena · Boston, MA |
| 5 | Thu Nov 20 | atPrinceton | L57-70 | 2-3 | .400 | - | ESPN+ | Jadwin Gymnasium · Princeton, NJ |
| 6 | Sat Nov 22 | atDuquesne | W93-86 | 3-3 | .500 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 7 | Fri Nov 28 | atWake Forest | L73-86 | 3-4 | .429 | - | ACC Extra | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 8 | Wed Dec 3 | atHoly Cross | L59-76 | 3-5 | .375 | - | ESPN+ | Hart Center · Worcester, MA |
| 9 | Sun Dec 7 | vsC Connecticut | W73-56 | 4-5 | .444 | - | | Matthews Arena · Boston, MA |
| 10 | Sat Dec 20 | atSyracuse | L83-91 | 4-6 | .400 | - | ACC Extra | JMA Wireless Dome · Syracuse, NY |
| 11 | Mon Dec 22 | atRhode Island | L77-85 | 4-7 | .364 | - | ESPN+ | Ryan Center · Kingston, RI |
| 12 | Mon Dec 29 | atElon | L91-103 | 4-8 | .333 | - | | Schar Center · Elon, NC |
| 13 | Wed Dec 31 | atNC A&T | W85-74 | 5-8 | .385 | - | | Corbett Sports Center · Greensboro, NC |
| 14 | Sat Jan 3 | atCampbell | L82-97 | 5-9 | .357 | - | CBSSN | John W. Pope Jr. Convocation Center · Buies Creek, NC |
| 15 | Thu Jan 8 | vsUNC Wilmington | L78-87 | 5-10 | .333 | - | | Matthews Arena · Boston, MA |
| 16 | Sat Jan 10 | vsTowson | L78-87 | 5-11 | .313 | - | | Matthews Arena · Boston, MA |
| 17 | Thu Jan 15 | vsElon | W85-78 | 6-11 | .353 | - | | Matthews Arena · Boston, MA |
| 18 | Mon Jan 19 | atMonmouth | L68-81 | 6-12 | .333 | - | CBSSN | OceanFirst Bank Center · West Long Branch, NJ |
| 19 | Thu Jan 22 | vsStony Brook | L80-95 | 6-13 | .316 | - | | Matthews Arena · Boston, MA |
| 20 | Sat Jan 24 | atDrexel | L78-83 | 6-14 | .300 | - | | Daskalakis Athletic Center · Philadelphia, PA |
| 21 | Sat Jan 31 | vsCharleston | L84-89 | 6-15 | .286 | - | | Matthews Arena · Boston, MA |
| 22 | Thu Feb 5 | atHofstra | L63-80 | 6-16 | .273 | - | | David S. Mack Sports and Exhibition Complex · Hempstead, NY |
| 23 | Sat Feb 7 | atStony Brook | L55-69 | 6-17 | .261 | - | | Island FCU Arena · Stony Brook, NY |
| 24 | Thu Feb 12 | vsWilliam & Mary | L67-94 | 6-18 | .250 | - | | Matthews Arena · Boston, MA |
| 25 | Thu Feb 19 | vsDrexel | L61-70 | 6-19 | .240 | - | | Matthews Arena · Boston, MA |
| 26 | Sat Feb 21 | vsHofstra | L68-82 | 6-20 | .231 | - | | Matthews Arena · Boston, MA |
| 27 | Thu Feb 26 | atWilliam & Mary | L77-84 | 6-21 | .222 | - | | Kaplan Arena · Williamsburg, VA |
| 28 | Sat Feb 28 | atHampton | L65-76 | 6-22 | .214 | - | | Convocation Center (VA) · Hampton, VA |
