| 1 | Mon Nov 4 | vs TBD | W95-43 | 1-0 | 1.000 | - | FloSports | Daskalakis Athletic Center · Philadelphia, PA |
| 2 | Sat Nov 9 | vs Colgate | W73-56 | 2-0 | 1.000 | - | FloSports | Daskalakis Athletic Center · Philadelphia, PA |
| 3 | Tue Nov 12 | at Temple | L61-69 | 2-1 | .667 | - | ESPN+ | Liacouras Center · Philadelphia, PA |
| 4 | Sat Nov 16 | vs La Salle | L68-71 | 2-2 | .500 | - | FloSports | Daskalakis Athletic Center · Philadelphia, PA |
| 5 | Tue Nov 19 | at Fairfield | W67-61 | 3-2 | .600 | - | ESPN+ | Leo D. Mahoney Arena · Fairfield, CT |
| 6 | Fri Nov 22 | at Fordham | W73-71 | 4-2 | .667 | - | ESPN+ | Rose Hill Gymnasium · Bronx, NY |
| 7 | Mon Nov 25 | at Purdue FW | L81-87 | 4-3 | .571 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 8 | Tue Nov 26 | at Chicago St | W83-71 | 5-3 | .625 | - | | Jones Convocation Center · Chicago, IL |
| 9 | Mon Dec 2 | vs Bryant | L73-78 | 5-4 | .556 | - | | Daskalakis Athletic Center · Philadelphia, PA |
| 10 | Sat Dec 7 | vs Penn | W60-47 | 6-4 | .600 | - | | Daskalakis Athletic Center · Philadelphia, PA |
| 11 | Sat Dec 14 | at Albany | W77-70 | 7-4 | .636 | - | ESPN+ | SEFCU Arena · Albany, NY |
| 12 | Tue Dec 17 | at Howard | W68-65 | 8-4 | .667 | - | ESPN+ | Burr Gymnasium · Washington, D.C. |
| 13 | Sat Dec 21 | vs Penn State | L64-75 | 8-5 | .615 | - | | Daskalakis Athletic Center · Philadelphia, PA |
| 14 | Thu Jan 2 | at Campbell | L54-57 | 8-6 | .571 | - | | John W. Pope Jr. Convocation Center · Buies Creek, NC |
| 15 | Sat Jan 4 | at NC A&T | W68-59 | 9-6 | .600 | - | | Corbett Sports Center · Greensboro, NC |
| 16 | Thu Jan 9 | at Stony Brook | W67-51 | 10-6 | .625 | - | | Island FCU Arena · Stony Brook, NY |
| 17 | Sat Jan 11 | vs Towson | L82-93 (OT) | 10-7 | .588 | - | | Daskalakis Athletic Center · Philadelphia, PA |
| 18 | Thu Jan 16 | vs Elon | L54-65 | 10-8 | .556 | - | | Daskalakis Athletic Center · Philadelphia, PA |
| 19 | Mon Jan 20 | vs Hofstra | W60-55 | 11-8 | .579 | - | CBS | Daskalakis Athletic Center · Philadelphia, PA |
| 20 | Thu Jan 23 | at Northeastern | L61-70 | 11-9 | .550 | - | | Matthews Arena · Boston, MA |
| 21 | Sat Jan 25 | vs Delaware | W67-54 | 12-9 | .571 | - | | Daskalakis Athletic Center · Philadelphia, PA |
| 22 | Thu Jan 30 | at Monmouth | L97-104 (2OT) | 12-10 | .545 | - | | OceanFirst Bank Center · West Long Branch, NJ |
| 23 | Sat Feb 1 | atTowson | L54-55 | 12-11 | .522 | - | CBS | SECU Arena · Towson, MD |
| 24 | Thu Feb 6 | vs William & Mary | W86-66 | 13-11 | .542 | - | | Daskalakis Athletic Center · Philadelphia, PA |
| 25 | Sat Feb 8 | vs UNC Wilmington | L79-81 (2OT) | 13-12 | .520 | - | CBS | Daskalakis Athletic Center · Philadelphia, PA |
| 26 | Thu Feb 13 | at Hampton | L58-63 | 13-13 | .500 | - | | Convocation Center (VA) · Hampton, VA |
| 27 | Sat Feb 15 | atWilliam & Mary | L59-72 | 13-14 | .481 | - | | Kaplan Arena · Williamsburg, VA |
| 28 | Thu Feb 20 | atDelaware | W78-74 | 14-14 | .500 | - | | Bob Carpenter Center · Newark, DE |
| 29 | Sat Feb 22 | vs Charleston | W64-55 | 15-14 | .517 | - | CBS | Daskalakis Athletic Center · Philadelphia, PA |
| 30 | Thu Feb 27 | vsHampton | W53-52 | 16-14 | .533 | - | | Daskalakis Athletic Center · Philadelphia, PA |
| 31 | Sat Mar 1 | vsMonmouth | W71-61 | 17-14 | .548 | - | | Daskalakis Athletic Center · Philadelphia, PA |
| 32 | Sat Mar 8 | vsElon | W91-74 | 18-14 | .563 | - | | Daskalakis Athletic Center · Philadelphia, PA |
| 33 | Sun Mar 9 | atTowson | L76-82 | 18-15 | .545 | - | | SECU Arena · Towson, MD |
