| 1 | Wed Nov 6 | vs Campbell | W65-56 | 1-0 | 1.000 | - | ESPN+ | John Paul Jones Arena · Charlottesville, VA |
| 2 | Mon Nov 11 | vs Coppin St | W62-45 | 2-0 | 1.000 | - | ESPN+ | John Paul Jones Arena · Charlottesville, VA |
| 3 | Fri Nov 15 | at Villanova | W70-60 | 3-0 | 1.000 | - | TNT | Finneran Pavilion · Villanova, PA |
| 4 | Thu Nov 21 | at #11Tennessee | L42-64 | 3-1 | .750 | - | CBS | Thompson-Boling Arena · Knoxville, TN |
| 5 | Fri Nov 22 | at #22St John's | L55-80 | 3-2 | .600 | - | CBS | Carnesecca Arena · Queens, NY |
| 6 | Tue Nov 26 | vs Manhattan | W74-65 | 4-2 | .667 | - | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 7 | Fri Nov 29 | vs Holy Cross | W67-41 | 5-2 | .714 | - | ESPN+ | John Paul Jones Arena · Charlottesville, VA |
| 8 | Wed Dec 4 | at #13Florida | L69-87 | 5-3 | .625 | - | ESPN2 | Exactech Arena at Stephen C. O'Connell Center · Gainesville, FL |
| 9 | Sat Dec 7 | at SMU | L51-63 | 5-4 | .556 | - | The CW Network | Moody Coliseum · Dallas, TX |
| 10 | Thu Dec 12 | vs Bethune | W59-41 | 6-4 | .600 | - | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 11 | Wed Dec 18 | vs #21Memphis | L62-64 | 6-5 | .545 | - | ESPN2 | John Paul Jones Arena · Charlottesville, VA |
| 12 | Sun Dec 22 | vs American | W63-58 | 7-5 | .583 | - | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 13 | Tue Dec 31 | vs NC State | W70-67 | 8-5 | .615 | - | ESPN2 | John Paul Jones Arena · Charlottesville, VA |
| 14 | Sat Jan 4 | vs Louisville | L50-70 | 8-6 | .571 | - | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 15 | Wed Jan 8 | at California | L61-75 | 8-7 | .533 | - | ESPN2 | Haas Pavilion · Berkeley, CA |
| 16 | Sat Jan 11 | at Stanford | L65-88 | 8-8 | .500 | - | ESPNU | Maples Pavilion · Stanford, CA |
| 17 | Wed Jan 15 | vsSMU | L52-54 | 8-9 | .471 | - | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 18 | Sat Jan 18 | atLouisville | L67-81 | 8-10 | .444 | - | ESPN2 | KFC Yum! Center · Louisville, KY |
| 19 | Tue Jan 21 | vs Boston College | W74-56 | 9-10 | .474 | - | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 20 | Sat Jan 25 | vs Notre Dame | L59-74 | 9-11 | .450 | - | ESPN2 | John Paul Jones Arena · Charlottesville, VA |
| 21 | Wed Jan 29 | at Miami | W82-71 | 10-11 | .476 | - | ESPNU | Watsco Center · Coral Gables, FL |
| 22 | Sat Feb 1 | vs Virginia Tech | L74-75 | 10-12 | .455 | - | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 23 | Mon Feb 3 | at Pitt | W73-57 | 11-12 | .478 | - | ESPN | Petersen Events Center · Pittsburgh, PA |
| 24 | Sat Feb 8 | vs Georgia Tech | W75-61 | 12-12 | .500 | - | The CW Network | John Paul Jones Arena · Charlottesville, VA |
| 25 | Sat Feb 15 | atVirginia Tech | W73-70 | 13-12 | .520 | - | The CW Network | Cassell Coliseum · Blacksburg, VA |
| 26 | Mon Feb 17 | vs #3Duke | L62-80 | 13-13 | .500 | - | ESPN | John Paul Jones Arena · Charlottesville, VA |
| 27 | Sat Feb 22 | at UNC | L66-81 | 13-14 | .481 | - | ESPN2 | Dean E. Smith Center · Chapel Hill, NC |
| 28 | Wed Feb 26 | at Wake Forest | W83-75 | 14-14 | .500 | - | ESPNU | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 29 | Sat Mar 1 | vs #13Clemson | L58-71 | 14-15 | .483 | - | ESPN2 | John Paul Jones Arena · Charlottesville, VA |
| 30 | Tue Mar 4 | vs Florida St | W60-57 | 15-15 | .500 | - | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 31 | Sat Mar 8 | at Syracuse | L70-84 | 15-16 | .484 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 32 | Wed Mar 12 | atGeorgia Tech | L60-66 | 15-17 | .469 | - | ESPN2 | McCamish Pavilion · Atlanta, GA |
