| 1 | Wed Nov 25 | vs Towson | W89-54 | 1-0 | 1.000 | - | | John Paul Jones Arena · Charlottesville, VA |
| 2 | Fri Nov 27 | atSan Francisco | L60-61 | 1-1 | .500 | - | ESPN | War Memorial at the Sobrato Center · San Francisco, CA |
| 3 | Tue Dec 1 | vsSt Francis PA | W76-51 | 2-1 | .667 | #15 | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 4 | Fri Dec 4 | vsKent State | W71-64 (OT) | 3-1 | .750 | #15 | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 6 | Sun Dec 13 | vsWilliam & Mary | PPD | 18-7 | .720 | #18 | | John Paul Jones Arena · Charlottesville, VA |
| 8 | Tue Dec 22 | vsWilliam & Mary | W76-40 | 4-1 | .800 | #16 | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 9 | Sat Dec 26 | at1Gonzaga | L75-98 | 4-2 | .667 | #16 | CBS | McCarthey Athletic Center · Spokane, WA |
| 10 | Wed Dec 30 | atNotre Dame | W66-57 | 5-2 | .714 | #23 | ACC Network | Purcell Pavilion · South Bend, IN |
| 12 | Wed Jan 6 | vsWake Forest | W70-61 | 6-2 | .750 | #22 | | John Paul Jones Arena · Charlottesville, VA |
| 13 | Sat Jan 9 | atBoston College | W61-49 | 7-2 | .778 | #22 | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 14 | Wed Jan 13 | vsNotre Dame | W80-68 | 8-2 | .800 | #18 | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 15 | Sat Jan 16 | at12Clemson | W85-50 | 9-2 | .818 | #18 | ESPN | Littlejohn Coliseum · Clemson, SC |
| 16 | Wed Jan 20 | vsNC State | PPD | 18-7 | .720 | #13 | | John Paul Jones Arena · Charlottesville, VA |
| 17 | Sat Jan 23 | vsGeorgia Tech | W64-62 | 10-2 | .833 | #13 | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 18 | Mon Jan 25 | vsSyracuse | W81-58 | 11-2 | .846 | #8 | ESPN | John Paul Jones Arena · Charlottesville, VA |
| 19 | Sat Jan 30 | at20Virginia Tech | L51-65 | 11-3 | .786 | #8 | ACC Network | Cassell Coliseum · Blacksburg, VA |
| 20 | Wed Feb 3 | atNC State | W64-57 | 12-3 | .800 | #14 | ACC Network | PNC Arena · Raleigh, NC |
| 21 | Sat Feb 6 | vsPitt | W73-66 | 13-3 | .813 | #14 | ESPN | John Paul Jones Arena · Charlottesville, VA |
| 22 | Wed Feb 10 | atGeorgia Tech | W57-49 | 14-3 | .824 | #9 | | McCamish Pavilion · Atlanta, GA |
| 23 | Sat Feb 13 | vsUNC | W60-48 | 15-3 | .833 | #9 | ESPN | John Paul Jones Arena · Charlottesville, VA |
| 24 | Mon Feb 15 | at16Florida St | L60-81 | 15-4 | .789 | #7 | ESPN | Donald L. Tucker Center · Tallahassee, FL |
| 25 | Sat Feb 20 | atDuke | L65-66 | 15-5 | .750 | #7 | ESPN | Cameron Indoor Stadium · Durham, NC |
| 26 | Wed Feb 24 | vsNC State | L61-68 | 15-6 | .714 | #15 | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 27 | Mon Mar 1 | vsMiami | W62-51 | 16-6 | .727 | #21 | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 28 | Sat Mar 6 | atLouisville | W68-58 | 17-6 | .739 | #21 | ESPN2 | KFC Yum! Center · Louisville, KY |
| 29 | Thu Mar 11 | vsSyracuse | W72-69 | 18-6 | .750 | - | ESPN2 | Greensboro Coliseum · Greensboro, NC |
| 27 | Sat Mar 20 | vs13Ohio | L58-62 | 18-7 | .720 | #4 | truTV | Simon Skjodt Assembly Hall · Bloomington, IN |
