| 1 | Mon Nov 6 | vs Tarleton | W80-50 | 1-0 | 1.000 | - | | John Paul Jones Arena · Charlottesville, VA |
| 2 | Fri Nov 10 | at Florida | W73-70 | 2-0 | 1.000 | - | ACC Network | Exactech Arena at Stephen C. O'Connell Center · Gainesville, FL |
| 3 | Tue Nov 14 | vs NC A&T | W80-51 | 3-0 | 1.000 | - | | John Paul Jones Arena · Charlottesville, VA |
| 4 | Thu Nov 16 | vs Texas So | W62-33 | 4-0 | 1.000 | - | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 5 | Mon Nov 20 | vs Wisconsin | L41-65 | 4-1 | .800 | #24 | FS1 | John Paul Jones Arena · Charlottesville, VA |
| 6 | Wed Nov 22 | vs West Virginia | W56-54 | 5-1 | .833 | #24 | FS1 | John Paul Jones Arena · Charlottesville, VA |
| 7 | Wed Nov 29 | vs #14Texas A&M | W59-47 | 6-1 | .857 | - | ESPN2 | John Paul Jones Arena · Charlottesville, VA |
| 8 | Sat Dec 2 | vs Syracuse | W84-62 | 7-1 | .875 | - | ESPN2 | John Paul Jones Arena · Charlottesville, VA |
| 9 | Tue Dec 5 | vs NC Central | W77-47 | 8-1 | .889 | - | | John Paul Jones Arena · Charlottesville, VA |
| 10 | Sat Dec 16 | vs Northeastern | W56-54 | 9-1 | .900 | #22 | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 11 | Tue Dec 19 | at #23Memphis | L54-77 | 9-2 | .818 | #22 | ESPN2 | FedExForum · Memphis, TN |
| 12 | Wed Dec 27 | vs Morgan St | W79-44 | 10-2 | .833 | - | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 13 | Sat Dec 30 | at Notre Dame | L54-76 | 10-3 | .769 | - | ACC Network | Purcell Pavilion · South Bend, IN |
| 14 | Wed Jan 3 | vs Louisville | W77-53 | 11-3 | .786 | - | ESPN2 | John Paul Jones Arena · Charlottesville, VA |
| 15 | Sat Jan 6 | at NC State | L60-76 | 11-4 | .733 | - | ACC Network | PNC Arena · Raleigh, NC |
| 16 | Sat Jan 13 | at Wake Forest | L47-66 | 11-5 | .688 | - | ESPN2 | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 17 | Wed Jan 17 | vs Virginia Tech | W65-57 | 12-5 | .706 | - | ESPNU | John Paul Jones Arena · Charlottesville, VA |
| 18 | Sat Jan 20 | at Georgia Tech | W75-66 | 13-5 | .722 | - | ACC Network | McCamish Pavilion · Atlanta, GA |
| 19 | Wed Jan 24 | vsNC State | W59-53 (OT) | 14-5 | .737 | - | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 20 | Sat Jan 27 | atLouisville | W69-52 | 15-5 | .750 | - | The CW Network | KFC Yum! Center · Louisville, KY |
| 21 | Wed Jan 31 | vsNotre Dame | W65-53 | 16-5 | .762 | - | ESPN2 | John Paul Jones Arena · Charlottesville, VA |
| 22 | Sat Feb 3 | at Clemson | W66-65 | 17-5 | .773 | - | ESPN | Littlejohn Coliseum · Clemson, SC |
| 23 | Mon Feb 5 | vs Miami | W60-38 | 18-5 | .783 | - | ESPN | John Paul Jones Arena · Charlottesville, VA |
| 24 | Sat Feb 10 | at Florida St | W80-76 | 19-5 | .792 | - | The CW Network | Donald L. Tucker Center · Tallahassee, FL |
| 25 | Tue Feb 13 | vs Pitt | L63-74 | 19-6 | .760 | #21 | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 26 | Sat Feb 17 | vsWake Forest | W49-47 | 20-6 | .769 | #21 | ESPN2 | John Paul Jones Arena · Charlottesville, VA |
| 27 | Mon Feb 19 | atVirginia Tech | L41-75 | 20-7 | .741 | - | ESPN | Cassell Coliseum · Blacksburg, VA |
| 28 | Sat Feb 24 | vs #10UNC | L44-54 | 20-8 | .714 | - | ESPN | John Paul Jones Arena · Charlottesville, VA |
| 29 | Wed Feb 28 | at Boston College | W72-68 | 21-8 | .724 | - | ESPNU | Silvio O. Conte Forum · Chestnut Hill, MA |
| 30 | Sat Mar 2 | at #10Duke | L48-73 | 21-9 | .700 | - | ESPN | Cameron Indoor Stadium · Durham, NC |
| 31 | Sat Mar 9 | vsGeorgia Tech | W72-57 | 22-9 | .710 | - | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 32 | Thu Mar 14 | vsBoston College | W66-60 (OT) | 23-9 | .719 | - | ESPN | John Paul Jones Arena · Charlottesville, VA |
| 33 | Fri Mar 15 | vsNC State | L65-73 (OT) | 23-10 | .697 | - | ESPN2 | John Paul Jones Arena · Charlottesville, VA |
| 34 | Tue Mar 19 | vs #10Colorado St | L42-67 | 23-11 | .676 | #10 | truTV | John Paul Jones Arena · Charlottesville, VA |
