| 1 | Mon Nov 7 | vs NC Central | W73-61 | 1-0 | 1.000 | #18 | | John Paul Jones Arena · Charlottesville, VA |
| 2 | Fri Nov 11 | vs Monmouth | W89-42 | 2-0 | 1.000 | #18 | | John Paul Jones Arena · Charlottesville, VA |
| 4 | Fri Nov 18 | at Baylor | W86-79 | 3-0 | 1.000 | - | ESPN2 | Ferrell Center · Waco, TX |
| 5 | Sun Nov 20 | vs Illinois | W70-61 | 4-0 | 1.000 | - | ESPN | John Paul Jones Arena · Charlottesville, VA |
| 6 | Fri Nov 25 | vs MD-Eastern | W72-45 | 5-0 | 1.000 | #5 | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 7 | Tue Nov 29 | at Michigan | W70-68 | 6-0 | 1.000 | - | ESPN | Crisler Center · Ann Arbor, MI |
| 8 | Sat Dec 3 | vs Florida St | W62-57 | 7-0 | 1.000 | #3 | ESPN2 | John Paul Jones Arena · Charlottesville, VA |
| 9 | Tue Dec 6 | vs JMU | W55-50 | 8-0 | 1.000 | #3 | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 10 | Sat Dec 17 | vs #5Houston | L61-69 | 8-1 | .889 | #2 | ESPN2 | John Paul Jones Arena · Charlottesville, VA |
| 11 | Tue Dec 20 | at #22Miami | L64-66 | 8-2 | .800 | #6 | ACC Network | Watsco Center · Coral Gables, FL |
| 12 | Wed Dec 28 | vs Albany | W66-46 | 9-2 | .818 | #13 | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 13 | Sat Dec 31 | at Georgia Tech | W74-56 | 10-2 | .833 | #13 | ACC Network | McCamish Pavilion · Atlanta, GA |
| 14 | Tue Jan 3 | at Pitt | L65-68 | 10-3 | .769 | #11 | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 15 | Sat Jan 7 | vs Syracuse | W73-66 | 11-3 | .786 | #11 | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 16 | Tue Jan 10 | vs UNC | W65-58 | 12-3 | .800 | #13 | ESPN | John Paul Jones Arena · Charlottesville, VA |
| 17 | Sat Jan 14 | atFlorida St | W67-58 | 13-3 | .813 | #13 | ESPN2 | Donald L. Tucker Center · Tallahassee, FL |
| 18 | Wed Jan 18 | vs Virginia Tech | W78-68 | 14-3 | .824 | #10 | ESPNU | John Paul Jones Arena · Charlottesville, VA |
| 19 | Sat Jan 21 | at Wake Forest | W76-67 | 15-3 | .833 | #10 | ESPNU | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 20 | Sat Jan 28 | vs Boston College | W76-57 | 16-3 | .842 | #7 | | John Paul Jones Arena · Charlottesville, VA |
| 21 | Mon Jan 30 | atSyracuse | W67-62 | 17-3 | .850 | #6 | ESPN | JMA Wireless Dome · Syracuse, NY |
| 22 | Sat Feb 4 | atVirginia Tech | L68-74 | 17-4 | .810 | #6 | ESPN2 | Cassell Coliseum · Blacksburg, VA |
| 23 | Tue Feb 7 | vs #22NC State | W63-50 | 18-4 | .818 | #8 | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 24 | Sat Feb 11 | vs Duke | W69-62 (OT) | 19-4 | .826 | - | ESPN | John Paul Jones Arena · Charlottesville, VA |
| 25 | Wed Feb 15 | at Louisville | W61-58 | 20-4 | .833 | #7 | ESPNU | KFC Yum! Center · Louisville, KY |
| 26 | Sat Feb 18 | vs Notre Dame | W57-55 | 21-4 | .840 | #7 | ESPN2 | John Paul Jones Arena · Charlottesville, VA |
| 27 | Wed Feb 22 | atBoston College | L48-63 | 21-5 | .808 | #6 | | Silvio O. Conte Forum · Chestnut Hill, MA |
| 28 | Sat Feb 25 | atUNC | L63-71 | 21-6 | .778 | #6 | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 29 | Tue Feb 28 | vs Clemson | W64-57 | 22-6 | .786 | #13 | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 30 | Sat Mar 4 | vsLouisville | W75-60 | 23-6 | .793 | #13 | ESPN2 | John Paul Jones Arena · Charlottesville, VA |
| 31 | Thu Mar 9 | vsUNC | W68-59 | 24-6 | .800 | - | ESPN | John Paul Jones Arena · Charlottesville, VA |
| 32 | Fri Mar 10 | vsClemson | W76-56 | 25-6 | .806 | - | ESPN2 | John Paul Jones Arena · Charlottesville, VA |
| 33 | Sat Mar 11 | vsDuke | L49-59 | 25-7 | .781 | - | ESPN | John Paul Jones Arena · Charlottesville, VA |
| 34 | Thu Mar 16 | vs #13Furman | L67-68 | 25-8 | .758 | #4 | truTV | John Paul Jones Arena · Charlottesville, VA |
Northern Iowa