| 1 | Wed Nov 6 | at Syracuse | W48-34 | 1-0 | 1.000 | #11 | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 2 | Sun Nov 10 | vsJMU | W65-34 | 2-0 | 1.000 | #11 | ESPNU | John Paul Jones Arena · Charlottesville, VA |
| 3 | Sat Nov 16 | vsColumbia | W60-42 | 3-0 | 1.000 | - | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 4 | Tue Nov 19 | vsVermont | W61-55 | 4-0 | 1.000 | - | | John Paul Jones Arena · Charlottesville, VA |
| 5 | Sat Nov 23 | vsUMass | W58-46 | 5-0 | 1.000 | - | ESPNEWS | John Paul Jones Arena · Charlottesville, VA |
| 6 | Sun Nov 24 | vsArizona St | W48-45 | 6-0 | 1.000 | - | ESPN | John Paul Jones Arena · Charlottesville, VA |
| 7 | Wed Nov 27 | vsMaine | W46-26 | 7-0 | 1.000 | #7 | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 8 | Wed Dec 4 | atPurdue | L40-69 | 7-1 | .875 | - | | Mackey Arena · West Lafayette, IN |
| 9 | Sun Dec 8 | vs7UNC | W56-47 | 8-1 | .889 | #5 | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 10 | Wed Dec 18 | vsStony Brook | W56-44 | 9-1 | .900 | #9 | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 11 | Sun Dec 22 | vsSouth Carolina | L59-70 | 9-2 | .818 | #9 | ABC | John Paul Jones Arena · Charlottesville, VA |
| 12 | Sun Dec 29 | vsNavy | W65-56 | 10-2 | .833 | #16 | ESPN2 | John Paul Jones Arena · Charlottesville, VA |
| 13 | Sat Jan 4 | vsVirginia Tech | W65-39 | 11-2 | .846 | #19 | | John Paul Jones Arena · Charlottesville, VA |
| 14 | Tue Jan 7 | atBoston College | L53-60 | 11-3 | .786 | #18 | ACC Network | Silvio O. Conte Forum · Chestnut Hill, MA |
| 15 | Sat Jan 11 | vsSyracuse | L55-63 (OT) | 11-4 | .733 | #18 | ESPN | John Paul Jones Arena · Charlottesville, VA |
| 16 | Wed Jan 15 | at9Florida St | L50-54 | 11-5 | .688 | - | ESPN2 | Donald L. Tucker Center · Tallahassee, FL |
| 17 | Sat Jan 18 | atGeorgia Tech | W63-58 | 12-5 | .706 | - | ACC Network | McCamish Pavilion · Atlanta, GA |
| 18 | Mon Jan 20 | vsNC State | L51-53 | 12-6 | .667 | - | ESPN | John Paul Jones Arena · Charlottesville, VA |
| 19 | Sun Jan 26 | atWake Forest | W65-63 (OT) | 13-6 | .684 | - | ACC Network | Lawrence Joel Veterans Memorial Coliseum · Winston-Salem, NC |
| 20 | Tue Jan 28 | vs5Florida St | W61-56 | 14-6 | .700 | - | ESPN | John Paul Jones Arena · Charlottesville, VA |
| 21 | Wed Feb 5 | vsClemson | W51-44 | 15-6 | .714 | - | | John Paul Jones Arena · Charlottesville, VA |
| 22 | Sat Feb 8 | at5Louisville | L73-80 | 15-7 | .682 | - | ESPN | KFC Yum! Center · Louisville, KY |
| 23 | Tue Feb 11 | vsNotre Dame | W50-49 (OT) | 16-7 | .696 | - | ESPN2 | John Paul Jones Arena · Charlottesville, VA |
| 24 | Sat Feb 15 | atUNC | W64-62 | 17-7 | .708 | - | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 25 | Wed Feb 19 | vsBoston College | W78-65 | 18-7 | .720 | - | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 26 | Sat Feb 22 | atPitt | W59-56 | 19-7 | .731 | - | ESPN2 | Petersen Events Center · Pittsburgh, PA |
| 27 | Wed Feb 26 | atVirginia Tech | W56-53 | 20-7 | .741 | - | ESPN2 | Cassell Coliseum · Blacksburg, VA |
| 28 | Sat Feb 29 | vs7Duke | W52-50 | 21-7 | .750 | - | ESPN | John Paul Jones Arena · Charlottesville, VA |
| 29 | Wed Mar 4 | atMiami | W46-44 | 22-7 | .759 | #22 | ACC Network | Watsco Center · Coral Gables, FL |
| 30 | Sat Mar 7 | vs10Louisville | W57-54 | 23-7 | .767 | #22 | ESPN | John Paul Jones Arena · Charlottesville, VA |
