| 1 | Tue Nov 9 | vs Navy | L58-66 | 0-1 | .000 | #25 | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 2 | Fri Nov 12 | vs Radford | W73-52 | 1-1 | .500 | #25 | | John Paul Jones Arena · Charlottesville, VA |
| 3 | Tue Nov 16 | at #15Houston | L47-67 | 1-2 | .333 | - | ESPN | Fertitta Center · Houston, TX |
| 4 | Fri Nov 19 | vs Coppin St | W68-52 | 2-2 | .500 | - | | John Paul Jones Arena · Charlottesville, VA |
| 5 | Mon Nov 22 | at Georgia | W65-55 | 3-2 | .600 | - | ESPNU | Stegeman Coliseum · Athens, GA |
| 6 | Tue Nov 23 | at Providence | W58-40 | 4-2 | .667 | - | ESPN2 | Amica Mutual Pavilion · Providence, RI |
| 7 | Fri Nov 26 | vs Lehigh | W61-43 | 5-2 | .714 | - | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 8 | Mon Nov 29 | vs Iowa | L74-75 | 5-3 | .625 | - | ESPN2 | John Paul Jones Arena · Charlottesville, VA |
| 9 | Fri Dec 3 | vs Pitt | W57-56 | 6-3 | .667 | - | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 10 | Tue Dec 7 | at JMU | L49-52 | 6-4 | .600 | - | CBS | Atlantic Union Bank Center · Harrisonburg, VA |
| 11 | Sat Dec 18 | vs Fairleigh | W82-49 | 7-4 | .636 | - | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 12 | Wed Dec 22 | vs Clemson | L50-67 | 7-5 | .583 | - | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 13 | Sat Jan 1 | at Syracuse | W74-69 | 8-5 | .615 | - | ACC Network | JMA Wireless Dome · Syracuse, NY |
| 14 | Tue Jan 4 | atClemson | W75-65 | 9-5 | .643 | - | | Littlejohn Coliseum · Clemson, SC |
| 15 | Sat Jan 8 | at UNC | L58-74 | 9-6 | .600 | - | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 16 | Wed Jan 12 | vs Virginia Tech | W54-52 | 10-6 | .625 | - | ESPN2 | John Paul Jones Arena · Charlottesville, VA |
| 17 | Sat Jan 15 | vs Wake Forest | L55-63 | 10-7 | .588 | - | | John Paul Jones Arena · Charlottesville, VA |
| 18 | Wed Jan 19 | atPitt | W66-61 | 11-7 | .611 | - | ACC Network | Petersen Events Center · Pittsburgh, PA |
| 19 | Sat Jan 22 | at NC State | L63-77 | 11-8 | .579 | - | ACC Network | PNC Arena · Raleigh, NC |
| 20 | Mon Jan 24 | vs Louisville | W64-52 | 12-8 | .600 | - | ESPN | John Paul Jones Arena · Charlottesville, VA |
| 21 | Sat Jan 29 | at Notre Dame | L65-69 | 12-9 | .571 | - | ACC Network | Purcell Pavilion · South Bend, IN |
| 22 | Tue Feb 1 | vs Boston College | W67-55 | 13-9 | .591 | - | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 23 | Sat Feb 5 | vs Miami | W71-58 | 14-9 | .609 | - | ACC Network | John Paul Jones Arena · Charlottesville, VA |
| 24 | Mon Feb 7 | at #7Duke | W69-68 | 15-9 | .625 | - | ESPN | Cameron Indoor Stadium · Durham, NC |
| 25 | Sat Feb 12 | vs Georgia Tech | W63-53 | 16-9 | .640 | - | ESPN2 | John Paul Jones Arena · Charlottesville, VA |
| 26 | Mon Feb 14 | atVirginia Tech | L53-62 | 16-10 | .615 | - | ESPN | Cassell Coliseum · Blacksburg, VA |
| 27 | Sat Feb 19 | atMiami | W74-71 | 17-10 | .630 | - | ACC Network | Watsco Center · Coral Gables, FL |
| 28 | Wed Feb 23 | vs#7Duke | L61-65 | 17-11 | .607 | - | ESPN | John Paul Jones Arena · Charlottesville, VA |
| 29 | Sat Feb 26 | vs Florida St | L63-64 | 17-12 | .586 | - | ESPN2 | John Paul Jones Arena · Charlottesville, VA |
| 30 | Sat Mar 5 | atLouisville | W71-61 | 18-12 | .600 | - | ESPN2 | KFC Yum! Center · Louisville, KY |
| 31 | Wed Mar 9 | vsLouisville | W51-50 | 19-12 | .613 | - | ESPN2 | John Paul Jones Arena · Charlottesville, VA |
| 32 | Thu Mar 10 | atUNC | L43-63 | 19-13 | .594 | - | ESPN | Dean E. Smith Center · Chapel Hill, NC |
| 33 | Wed Mar 16 | vs Mississippi St | W60-57 | 20-13 | .606 | - | ESPN2 | John Paul Jones Arena · Charlottesville, VA |
| 34 | Sun Mar 20 | at North Texas | W71-69 (OT) | 21-13 | .618 | - | | The Super Pit · Denton, TX |
| 35 | Tue Mar 22 | vs St Bonaventure | L51-52 | 21-14 | .600 | - | ESPN | John Paul Jones Arena · Charlottesville, VA |
