| 1 | Mon Nov 4 | at Pitt | L56-96 | 0-1 | .000 | - | ESPN+ | Petersen Events Center · Pittsburgh, PA |
| 2 | Fri Nov 8 | vs William & Mary | W89-77 | 1-1 | .500 | - | ESPN+ | Donald N. Dedmon Center · Radford, VA |
| 3 | Tue Nov 12 | vs Old Dominion | W87-75 | 2-1 | .667 | - | ESPN+ | Donald N. Dedmon Center · Radford, VA |
| 4 | Sat Nov 16 | at Evansville | W92-81 | 3-1 | .750 | - | ESPN+ | Ford Center · Evansville, IN |
| 5 | Mon Nov 18 | vs TBD | W96-50 | 4-1 | .800 | - | ESPN+ | Donald N. Dedmon Center · Radford, VA |
| 6 | Thu Nov 21 | at Clemson | L51-79 | 4-2 | .667 | - | ESPN+ | Littlejohn Coliseum · Clemson, SC |
| 7 | Mon Nov 25 | at Chicago St | W63-48 | 5-2 | .714 | - | | Jones Convocation Center · Chicago, IL |
| 8 | Tue Nov 26 | at Purdue FW | W69-56 | 6-2 | .750 | - | | Allen County War Memorial Coliseum · Fort Wayne, IN |
| 9 | Sun Dec 1 | at St Francis PA | W79-70 | 7-2 | .778 | - | | DeGol Arena · Loretto, PA |
| 10 | Thu Dec 5 | at NC Central | W70-67 | 8-2 | .800 | - | ESPN+ | McDougald-McLendon Arena · Durham, NC |
| 11 | Sun Dec 8 | vs Bucknell | W74-70 (OT) | 9-2 | .818 | - | ESPN+ | Donald N. Dedmon Center · Radford, VA |
| 12 | Sat Dec 14 | at Utah | L63-81 | 9-3 | .750 | - | ESPN+ | Jon M. Huntsman Center · Salt Lake City, UT |
| 13 | Tue Dec 17 | at Colorado St | L68-78 | 9-4 | .692 | - | | Moby Arena · Fort Collins, CO |
| 14 | Fri Dec 20 | vsTBD | W122-63 | 10-4 | .714 | - | ESPN+ | Donald N. Dedmon Center · Radford, VA |
| 15 | Sun Dec 22 | at South Carolina | L48-74 | 10-5 | .667 | - | ESPN+ | Colonial Life Arena · Columbia, SC |
| 16 | Thu Jan 2 | at High Point | L58-76 | 10-6 | .625 | - | ESPNU | Nido and Mariana Qubein Arena · High Point, NC |
| 17 | Sat Jan 4 | vs Winthrop | W87-67 | 11-6 | .647 | - | ESPN+ | Donald N. Dedmon Center · Radford, VA |
| 18 | Sat Jan 11 | at SC Upstate | W80-67 | 12-6 | .667 | - | ESPN+ | G.B. Hodge Center · Spartanburg, SC |
| 19 | Wed Jan 15 | vs Gardner-Webb | W79-75 | 13-6 | .684 | - | ESPN+ | Donald N. Dedmon Center · Radford, VA |
| 20 | Sat Jan 18 | at Charleston So | L54-58 | 13-7 | .650 | - | ESPN+ | Buccaneer Fieldhouse · Charleston, SC |
| 21 | Wed Jan 22 | vs Longwood | L74-77 | 13-8 | .619 | - | ESPN+ | Donald N. Dedmon Center · Radford, VA |
| 22 | Sat Jan 25 | at Presbyterian | W82-69 | 14-8 | .636 | - | ESPN+ | Ross E. Templeton P.E. Center · Clinton, SC |
| 23 | Wed Jan 29 | at UNC Asheville | L65-72 | 14-9 | .609 | - | ESPN+ | Kimmel Arena · Asheville, NC |
| 24 | Sat Feb 1 | vsSC Upstate | W79-69 | 15-9 | .625 | - | ESPN+ | Donald N. Dedmon Center · Radford, VA |
| 25 | Wed Feb 5 | vsHigh Point | L75-78 | 15-10 | .600 | - | ESPN+ | Donald N. Dedmon Center · Radford, VA |
| 26 | Sat Feb 8 | atLongwood | W71-69 | 16-10 | .615 | - | ESPN+ | Willett Hall · Farmville, VA |
| 27 | Wed Feb 12 | atWinthrop | L74-78 | 16-11 | .593 | - | ESPN+ | Winthrop Coliseum · Rock Hill, SC |
| 28 | Thu Feb 20 | vsUNC Asheville | W77-53 | 17-11 | .607 | - | ESPNU | Donald N. Dedmon Center · Radford, VA |
