| 1 | Mon Nov 4 | vs TBD | W125-65 | 1-0 | 1.000 | - | ESPN+ | Winthrop Coliseum · Rock Hill, SC |
| 2 | Sat Nov 9 | vs Little Rock | W82-67 | 2-0 | 1.000 | - | ESPN+ | Winthrop Coliseum · Rock Hill, SC |
| 3 | Mon Nov 11 | at Virginia Tech | L52-58 | 2-1 | .667 | - | ESPN+ | Cassell Coliseum · Blacksburg, VA |
| 4 | Fri Nov 15 | vs William & Mary | W86-85 | 3-1 | .750 | - | | Winthrop Coliseum · Rock Hill, SC |
| 5 | Sat Nov 16 | vs Georgia So | L87-89 | 3-2 | .600 | - | ESPN+ | Winthrop Coliseum · Rock Hill, SC |
| 6 | Sun Nov 17 | vs NC Central | W77-75 | 4-2 | .667 | - | ESPN+ | Winthrop Coliseum · Rock Hill, SC |
| 7 | Fri Nov 22 | at Louisville | L61-76 | 4-3 | .571 | - | ESPN+ | KFC Yum! Center · Louisville, KY |
| 8 | Mon Nov 25 | vs Long Island | W87-65 | 5-3 | .625 | - | ESPN+ | Winthrop Coliseum · Rock Hill, SC |
| 9 | Wed Nov 27 | vsTBD | W99-56 | 6-3 | .667 | - | ESPN+ | Winthrop Coliseum · Rock Hill, SC |
| 10 | Tue Dec 3 | at Queens | W86-78 | 7-3 | .700 | - | ESPN+ | Curry Arena · Charlotte, NC |
| 11 | Sat Dec 7 | vs Coast Car | W96-89 | 8-3 | .727 | - | ESPN+ | Winthrop Coliseum · Rock Hill, SC |
| 12 | Thu Dec 12 | vsTBD | W103-55 | 9-3 | .750 | - | ESPN+ | Winthrop Coliseum · Rock Hill, SC |
| 13 | Tue Dec 17 | at Florida St | L64-82 | 9-4 | .692 | - | ESPN+ | Donald L. Tucker Center · Tallahassee, FL |
| 14 | Sat Dec 21 | vs Mercer | W102-97 | 10-4 | .714 | - | ESPN+ | Winthrop Coliseum · Rock Hill, SC |
| 15 | Sun Dec 29 | at Indiana | L68-77 | 10-5 | .667 | - | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 16 | Thu Jan 2 | vs SC Upstate | W95-76 | 11-5 | .688 | - | ESPN+ | Winthrop Coliseum · Rock Hill, SC |
| 17 | Sat Jan 4 | at Radford | L67-87 | 11-6 | .647 | - | ESPN+ | Donald N. Dedmon Center · Radford, VA |
| 18 | Wed Jan 8 | at Gardner-Webb | L83-89 | 11-7 | .611 | - | ESPN+ | Paul Porter Arena · Boiling Springs, NC |
| 19 | Sat Jan 11 | vs Longwood | W95-76 | 12-7 | .632 | - | ESPN+ | Winthrop Coliseum · Rock Hill, SC |
| 20 | Wed Jan 15 | vs Charleston So | W102-97 (3OT) | 13-7 | .650 | - | ESPN+ | Winthrop Coliseum · Rock Hill, SC |
| 21 | Sat Jan 18 | at UNC Asheville | L84-93 | 13-8 | .619 | - | ESPN+ | Kimmel Arena · Asheville, NC |
| 22 | Sat Jan 25 | at High Point | L62-84 | 13-9 | .591 | - | ESPN+ | Nido and Mariana Qubein Arena · High Point, NC |
| 23 | Wed Jan 29 | vs Presbyterian | W76-67 | 14-9 | .609 | - | ESPN+ | Winthrop Coliseum · Rock Hill, SC |
| 24 | Sat Feb 1 | vsGardner-Webb | W96-93 | 15-9 | .625 | - | ESPN+ | Winthrop Coliseum · Rock Hill, SC |
| 25 | Wed Feb 5 | atCharleston So | W83-65 | 16-9 | .640 | - | ESPN+ | Buccaneer Fieldhouse · Charleston, SC |
| 26 | Sat Feb 8 | atSC Upstate | W105-95 | 17-9 | .654 | - | ESPN+ | G.B. Hodge Center · Spartanburg, SC |
| 27 | Wed Feb 12 | vsRadford | W78-74 | 18-9 | .667 | - | ESPN+ | Winthrop Coliseum · Rock Hill, SC |
| 28 | Sat Feb 15 | vsHigh Point | L66-88 | 18-10 | .643 | - | ESPN+ | Winthrop Coliseum · Rock Hill, SC |
| 29 | Wed Feb 19 | atPresbyterian | W81-77 | 19-10 | .655 | - | ESPN+ | Ross E. Templeton P.E. Center · Clinton, SC |
