| 1 | Tue Nov 9 | vs TBD | W110-78 | 1-0 | 1.000 | - | | Winthrop Coliseum · Rock Hill, SC |
| 2 | Sat Nov 13 | vs Mercer | W88-85 (OT) | 2-0 | 1.000 | - | | Winthrop Coliseum · Rock Hill, SC |
| 3 | Tue Nov 16 | at MTSU | L65-76 | 2-1 | .667 | - | | Murphy Center · Murfreesboro, TN |
| 4 | Sat Nov 20 | at Vanderbilt | L63-77 | 2-2 | .500 | - | | Memorial Gymnasium (TN) · Nashville, TN |
| 5 | Mon Nov 22 | at Washington St | L86-92 | 2-3 | .400 | - | PACN | Friel Court at Beasley Coliseum · Pullman, WA |
| 6 | Sat Nov 27 | at Washington | W82-74 | 3-3 | .500 | - | PACN | Alaska Airlines Arena · Seattle, WA |
| 7 | Wed Dec 1 | vsTBD | W82-75 | 4-3 | .571 | - | | Winthrop Coliseum · Rock Hill, SC |
| 8 | Sat Dec 4 | at Coast Car | L64-74 | 4-4 | .500 | - | | The HTC Center · Conway, SC |
| 9 | Tue Dec 7 | vs Furman | W85-80 | 5-4 | .556 | - | | Winthrop Coliseum · Rock Hill, SC |
| 10 | Sat Dec 11 | atTBD | W83-52 | 6-4 | .600 | - | | Rock Hill Sports & Event Center |
| 11 | Wed Dec 15 | at Elon | L61-63 | 6-5 | .545 | - | | Schar Center · Elon, NC |
| 12 | Tue Dec 21 | at Mississippi St | L63-84 | 6-6 | .500 | - | | Humphrey Coliseum · Starkville, MS |
| 13 | Fri Dec 31 | vsTBD | W78-40 | 7-6 | .538 | - | | Winthrop Coliseum · Rock Hill, SC |
| 14 | Wed Jan 5 | at High Point | PPD | 23-9 | .719 | - | | Nido and Mariana Qubein Arena · High Point, NC |
| 15 | Mon Jan 10 | vs Campbell | W74-72 | 8-6 | .571 | - | | Winthrop Coliseum · Rock Hill, SC |
| 16 | Thu Jan 13 | vs UNC Asheville | W86-80 (OT) | 9-6 | .600 | - | ESPNU | Winthrop Coliseum · Rock Hill, SC |
| 17 | Sat Jan 15 | at Charleston So | W70-65 | 10-6 | .625 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 18 | Thu Jan 20 | at Presbyterian | W60-58 | 11-6 | .647 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 19 | Sat Jan 22 | vs Gardner-Webb | W64-62 | 12-6 | .667 | - | | Winthrop Coliseum · Rock Hill, SC |
| 20 | Mon Jan 24 | atHigh Point | L56-65 | 12-7 | .632 | - | | Nido and Mariana Qubein Arena · High Point, NC |
| 21 | Wed Jan 26 | at SC Upstate | W95-91 (OT) | 13-7 | .650 | - | | G.B. Hodge Center · Spartanburg, SC |
| 22 | Sat Jan 29 | at Longwood | L88-92 | 13-8 | .619 | - | | Willett Hall · Farmville, VA |
| 23 | Thu Feb 3 | vs NC A&T | W64-54 | 14-8 | .636 | - | ESPNU | Winthrop Coliseum · Rock Hill, SC |
| 24 | Sat Feb 5 | at Hampton | W69-57 | 15-8 | .652 | - | | Convocation Center (VA) · Hampton, VA |
| 25 | Wed Feb 9 | vs Radford | W58-48 | 16-8 | .667 | - | | Winthrop Coliseum · Rock Hill, SC |
| 26 | Sat Feb 12 | vsPresbyterian | W65-61 | 17-8 | .680 | - | | Winthrop Coliseum · Rock Hill, SC |
| 27 | Wed Feb 16 | atGardner-Webb | W81-70 | 18-8 | .692 | - | | Paul Porter Arena · Boiling Springs, NC |
| 28 | Sat Feb 19 | atUNC Asheville | W84-79 | 19-8 | .704 | - | | Kimmel Arena · Asheville, NC |
| 29 | Thu Feb 24 | vsSC Upstate | W89-59 | 20-8 | .714 | - | ESPNU | Winthrop Coliseum · Rock Hill, SC |
| 30 | Sat Feb 26 | vsCharleston So | W92-86 | 21-8 | .724 | - | | Winthrop Coliseum · Rock Hill, SC |
| 31 | Fri Mar 4 | vsHigh Point | W68-51 | 22-8 | .733 | - | | Winthrop Coliseum · Rock Hill, SC |
| 32 | Sat Mar 5 | vsGardner-Webb | W76-67 | 23-8 | .742 | - | | Winthrop Coliseum · Rock Hill, SC |
| 33 | Sun Mar 6 | atLongwood | L58-79 | 23-9 | .719 | - | ESPN2 | Willett Hall · Farmville, VA |
