| 1 | Thu Nov 7 | at TBD | W67-57 | 1-0 | 1.000 | - | | Chase Arena |
| 2 | Sun Nov 10 | at Fresno St | L74-77 | 1-1 | .500 | - | | Save Mart Center · Fresno, CA |
| 3 | Mon Nov 11 | at #18Saint Mary's | W61-59 | 2-1 | .667 | - | | University Credit Union Pavilion · Moraga, CA |
| 4 | Thu Nov 14 | at ETSU | L58-61 | 2-2 | .500 | - | | Freedom Hall Civic Center · Johnson City, TN |
| 5 | Sat Nov 16 | vsTBD | W103-59 | 3-2 | .600 | - | | Winthrop Coliseum · Rock Hill, SC |
| 6 | Thu Nov 21 | vs Tennessee Tech | L58-61 | 3-3 | .500 | - | | Winthrop Coliseum · Rock Hill, SC |
| 7 | Mon Nov 25 | vsTBD | W127-83 | 4-3 | .571 | - | | Winthrop Coliseum · Rock Hill, SC |
| 8 | Fri Nov 29 | at #1Duke | L70-83 | 4-4 | .500 | - | ACC Network | Cameron Indoor Stadium · Durham, NC |
| 9 | Sat Dec 7 | vs Coast Car | L88-92 | 4-5 | .444 | - | | Winthrop Coliseum · Rock Hill, SC |
| 10 | Wed Dec 11 | at TCU | L60-70 | 4-6 | .400 | - | | Ed and Rae Schollmaier Arena · Fort Worth, TX |
| 11 | Sat Dec 14 | at Furman | L73-80 | 4-7 | .364 | - | | Timmons Arena · Greenville, SC |
| 12 | Tue Dec 17 | vs SIUE | W93-73 | 5-7 | .417 | - | | Winthrop Coliseum · Rock Hill, SC |
| 13 | Sat Dec 21 | vs Elon | W85-80 | 6-7 | .462 | - | | Winthrop Coliseum · Rock Hill, SC |
| 14 | Thu Jan 2 | vs Longwood | W91-67 | 7-7 | .500 | - | | Winthrop Coliseum · Rock Hill, SC |
| 15 | Sat Jan 4 | at Campbell | W87-72 | 8-7 | .533 | - | | John W. Pope Jr. Convocation Center · Buies Creek, NC |
| 16 | Wed Jan 8 | at High Point | W79-57 | 9-7 | .563 | - | | Nido and Mariana Qubein Arena · High Point, NC |
| 17 | Sat Jan 11 | vs Gardner-Webb | W99-95 (3OT) | 10-7 | .588 | - | | Winthrop Coliseum · Rock Hill, SC |
| 18 | Thu Jan 16 | at Hampton | W116-95 | 11-7 | .611 | - | | Convocation Center (VA) · Hampton, VA |
| 19 | Mon Jan 20 | at Radford | W61-56 | 12-7 | .632 | - | | Donald N. Dedmon Center · Radford, VA |
| 20 | Thu Jan 23 | vs SC Upstate | W79-53 | 13-7 | .650 | - | | Winthrop Coliseum · Rock Hill, SC |
| 21 | Sat Jan 25 | vs Presbyterian | W72-57 | 14-7 | .667 | - | | Winthrop Coliseum · Rock Hill, SC |
| 22 | Thu Jan 30 | at Charleston So | W77-60 | 15-7 | .682 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 23 | Sat Feb 1 | vs UNC Asheville | W104-71 | 16-7 | .696 | - | | Winthrop Coliseum · Rock Hill, SC |
| 24 | Thu Feb 6 | vsCampbell | W62-53 | 17-7 | .708 | - | ESPNU | Winthrop Coliseum · Rock Hill, SC |
| 25 | Sat Feb 8 | atLongwood | W70-68 | 18-7 | .720 | - | | Willett Hall · Farmville, VA |
| 26 | Mon Feb 10 | vsRadford | L77-81 | 18-8 | .692 | - | | Winthrop Coliseum · Rock Hill, SC |
| 27 | Thu Feb 13 | atGardner-Webb | L70-74 | 18-9 | .667 | - | ESPNU | Paul Porter Arena · Boiling Springs, NC |
| 28 | Sat Feb 15 | atPresbyterian | W89-88 | 19-9 | .679 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 29 | Sat Feb 22 | vsHampton | L81-87 | 19-10 | .655 | - | | Winthrop Coliseum · Rock Hill, SC |
| 30 | Thu Feb 27 | atSC Upstate | W90-82 | 20-10 | .667 | - | | G.B. Hodge Center · Spartanburg, SC |
| 31 | Sat Feb 29 | vsHigh Point | W84-76 | 21-10 | .677 | - | | Winthrop Coliseum · Rock Hill, SC |
| 32 | Thu Mar 5 | vsSC Upstate | W106-70 | 22-10 | .688 | - | | Winthrop Coliseum · Rock Hill, SC |
| 33 | Fri Mar 6 | vsGardner-Webb | W78-66 | 23-10 | .697 | - | | Winthrop Coliseum · Rock Hill, SC |
| 34 | Sun Mar 8 | vsHampton | W76-68 | 24-10 | .706 | - | ESPN | Winthrop Coliseum · Rock Hill, SC |
