| 1 | Mon Nov 6 | at Clemson | L56-78 | 0-1 | .000 | - | | Littlejohn Coliseum · Clemson, SC |
| 2 | Wed Nov 8 | vs TBD | W98-44 | 1-1 | .500 | - | | Winthrop Coliseum · Rock Hill, SC |
| 3 | Sat Nov 11 | vs Drexel | L72-74 | 1-2 | .333 | - | | Winthrop Coliseum · Rock Hill, SC |
| 4 | Fri Nov 17 | vs Holy Cross | W89-51 | 2-2 | .500 | - | | Winthrop Coliseum · Rock Hill, SC |
| 5 | Sat Nov 18 | at IU Indy | W74-61 | 3-2 | .600 | - | | Indiana Farmers Coliseum · Indianapolis, IN |
| 6 | Sun Nov 19 | vs Elon | W78-70 | 4-2 | .667 | - | | Winthrop Coliseum · Rock Hill, SC |
| 7 | Fri Nov 24 | at Georgia | L69-78 | 4-3 | .571 | - | | Stegeman Coliseum · Athens, GA |
| 8 | Tue Nov 28 | vsTBD | W90-49 | 5-3 | .625 | - | | Winthrop Coliseum · Rock Hill, SC |
| 9 | Sat Dec 2 | at Coast Car | W90-87 | 6-3 | .667 | - | | The HTC Center · Conway, SC |
| 10 | Tue Dec 5 | vs Queens | W88-82 | 7-3 | .700 | - | | Winthrop Coliseum · Rock Hill, SC |
| 11 | Sun Dec 10 | at Little Rock | W85-68 | 8-3 | .727 | - | | Jack Stephens Center · Little Rock, AR |
| 12 | Sat Dec 16 | at Xavier | L59-75 | 8-4 | .667 | - | FS1 | Cintas Center · Cincinnati, OH |
| 13 | Tue Dec 19 | at South Carolina | L62-72 | 8-5 | .615 | - | | Colonial Life Arena · Columbia, SC |
| 14 | Fri Dec 22 | at Florida St | L61-67 | 8-6 | .571 | - | | Donald L. Tucker Center · Tallahassee, FL |
| 15 | Fri Dec 29 | vsTBD | W113-62 | 9-6 | .600 | - | | Winthrop Coliseum · Rock Hill, SC |
| 16 | Wed Jan 3 | vs Longwood | W68-60 (OT) | 10-6 | .625 | - | | Winthrop Coliseum · Rock Hill, SC |
| 17 | Sat Jan 6 | at SC Upstate | W82-80 (OT) | 11-6 | .647 | - | | G.B. Hodge Center · Spartanburg, SC |
| 18 | Wed Jan 10 | at Presbyterian | W81-71 | 12-6 | .667 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 19 | Sat Jan 13 | vs Radford | W92-88 (3OT) | 13-6 | .684 | - | | Winthrop Coliseum · Rock Hill, SC |
| 20 | Thu Jan 18 | vs UNC Asheville | L77-82 | 13-7 | .650 | - | ESPNU | Winthrop Coliseum · Rock Hill, SC |
| 21 | Sat Jan 20 | at Gardner-Webb | L74-79 | 13-8 | .619 | - | | Paul Porter Arena · Boiling Springs, NC |
| 22 | Wed Jan 24 | at Charleston So | W78-59 | 14-8 | .636 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 23 | Sat Jan 27 | vs High Point | L81-83 | 14-9 | .609 | - | | Winthrop Coliseum · Rock Hill, SC |
| 24 | Sat Feb 3 | atUNC Asheville | L78-82 | 14-10 | .583 | - | | Kimmel Arena · Asheville, NC |
| 25 | Wed Feb 7 | vsCharleston So | W67-46 | 15-10 | .600 | - | | Winthrop Coliseum · Rock Hill, SC |
| 26 | Sat Feb 10 | atLongwood | L74-84 | 15-11 | .577 | - | | Willett Hall · Farmville, VA |
| 27 | Thu Feb 15 | atRadford | W85-69 | 16-11 | .593 | - | ESPNU | Donald N. Dedmon Center · Radford, VA |
| 28 | Wed Feb 21 | vsPresbyterian | L55-78 | 16-12 | .571 | - | | Winthrop Coliseum · Rock Hill, SC |
| 29 | Sat Feb 24 | vsSC Upstate | W83-74 | 17-12 | .586 | - | | Winthrop Coliseum · Rock Hill, SC |
| 30 | Wed Feb 28 | atHigh Point | L96-100 (OT) | 17-13 | .567 | - | | Nido and Mariana Qubein Arena · High Point, NC |
| 31 | Sat Mar 2 | vsGardner-Webb | L64-65 | 17-14 | .548 | - | | Winthrop Coliseum · Rock Hill, SC |
| 32 | Fri Mar 8 | vsLongwood | L56-69 | 17-15 | .531 | - | | Winthrop Coliseum · Rock Hill, SC |
