| 1 | Mon Nov 7 | at Penn State | L68-93 | 0-1 | .000 | - | | Bryce Jordan Center · University Park, PA |
| 2 | Wed Nov 9 | vs TBD | W78-56 | 1-1 | .500 | - | | Winthrop Coliseum · Rock Hill, SC |
| 3 | Sat Nov 12 | vs MTSU | W76-68 | 2-1 | .667 | - | | Winthrop Coliseum · Rock Hill, SC |
| 4 | Tue Nov 15 | at #13Auburn | L65-89 | 2-2 | .500 | - | SEC Network | Neville Arena · Auburn, AL |
| 5 | Sat Nov 19 | at Mercer | L68-77 | 2-3 | .400 | - | | Hawkins Arena · Macon, GA |
| 6 | Tue Nov 22 | vs Southern Miss | L52-77 | 2-4 | .333 | - | | Winthrop Coliseum · Rock Hill, SC |
| 7 | Wed Nov 23 | vs E Michigan | W101-87 | 3-4 | .429 | - | | Winthrop Coliseum · Rock Hill, SC |
| 8 | Tue Nov 29 | vsTBD | W99-52 | 4-4 | .500 | - | | Winthrop Coliseum · Rock Hill, SC |
| 9 | Sat Dec 3 | vs Coast Car | L81-86 | 4-5 | .444 | - | | Winthrop Coliseum · Rock Hill, SC |
| 10 | Tue Dec 6 | vs SC State | W81-67 | 5-5 | .500 | - | | Winthrop Coliseum · Rock Hill, SC |
| 11 | Sat Dec 10 | at Furman | L67-82 | 5-6 | .455 | - | | Timmons Arena · Greenville, SC |
| 12 | Sat Dec 17 | at LSU | L81-89 | 5-7 | .417 | - | SEC Network | Pete Maravich Assembly Center · Baton Rouge, LA |
| 13 | Wed Dec 21 | at Duquesne | L57-74 | 5-8 | .385 | - | | UPMC Cooper Fieldhouse · Pittsburgh, PA |
| 14 | Thu Dec 29 | at SC Upstate | L62-70 | 5-9 | .357 | - | | G.B. Hodge Center · Spartanburg, SC |
| 15 | Sat Dec 31 | vs UNC Asheville | W62-60 | 6-9 | .400 | - | | Winthrop Coliseum · Rock Hill, SC |
| 16 | Wed Jan 4 | vs Presbyterian | W82-72 | 7-9 | .438 | - | | Winthrop Coliseum · Rock Hill, SC |
| 17 | Sat Jan 7 | at Longwood | L71-85 | 7-10 | .412 | - | | Willett Hall · Farmville, VA |
| 18 | Wed Jan 11 | vs Radford | L52-66 | 7-11 | .389 | - | | Winthrop Coliseum · Rock Hill, SC |
| 19 | Sat Jan 14 | at Campbell | W78-74 | 8-11 | .421 | - | | John W. Pope Jr. Convocation Center · Buies Creek, NC |
| 20 | Wed Jan 18 | at High Point | L66-71 | 8-12 | .400 | - | | Nido and Mariana Qubein Arena · High Point, NC |
| 21 | Sat Jan 21 | vs Gardner-Webb | L61-63 | 8-13 | .381 | - | | Winthrop Coliseum · Rock Hill, SC |
| 22 | Wed Jan 25 | vs Charleston So | W76-64 | 9-13 | .409 | - | | Winthrop Coliseum · Rock Hill, SC |
| 23 | Sat Jan 28 | atPresbyterian | W76-58 | 10-13 | .435 | - | | Ross E. Templeton P.E. Center · Clinton, SC |
| 24 | Wed Feb 1 | vsLongwood | W76-74 | 11-13 | .458 | - | | Winthrop Coliseum · Rock Hill, SC |
| 25 | Sat Feb 4 | atRadford | L66-69 | 11-14 | .440 | - | | Donald N. Dedmon Center · Radford, VA |
| 26 | Wed Feb 8 | atUNC Asheville | L79-86 | 11-15 | .423 | - | | Kimmel Arena · Asheville, NC |
| 27 | Sat Feb 11 | vsSC Upstate | L70-79 | 11-16 | .407 | - | | Winthrop Coliseum · Rock Hill, SC |
| 28 | Wed Feb 15 | atGardner-Webb | W86-78 | 12-16 | .429 | - | | Paul Porter Arena · Boiling Springs, NC |
| 29 | Sat Feb 18 | atCharleston So | W75-67 | 13-16 | .448 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 30 | Wed Feb 22 | vsCampbell | W95-93 (OT) | 14-16 | .467 | - | | Winthrop Coliseum · Rock Hill, SC |
| 31 | Sat Feb 25 | vsHigh Point | W84-78 | 15-16 | .484 | - | | Winthrop Coliseum · Rock Hill, SC |
| 32 | Fri Mar 3 | atRadford | L69-78 | 15-17 | .469 | - | | Donald N. Dedmon Center · Radford, VA |
